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Protein
Submitted name:

Segment polarity protein dishevelled homolog DVL-2

Gene

DVL2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Biological processWnt signaling pathwayPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Segment polarity protein dishevelled homolog DVL-2Imported
Gene namesi
Name:DVL2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000004975.11
HGNCiHGNC:3086 DVL2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000004975

PTM / Processingi

Proteomic databases

MaxQBiI3L0M7
PeptideAtlasiI3L0M7
PRIDEiI3L0M7

Expressioni

Gene expression databases

BgeeiENSG00000004975 Expressed in 220 organ(s), highest expression level in vagina
ExpressionAtlasiI3L0M7 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliI3L0M7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 31DIXInterPro annotationAdd BLAST31
Domaini201 – 273PDZInterPro annotationAdd BLAST73

Phylogenomic databases

eggNOGiKOG3571 Eukaryota
ENOG410Y5G4 LUCA
GeneTreeiENSGT00390000013552

Family and domain databases

Gene3Di3.10.20.380, 1 hit
InterProiView protein in InterPro
IPR003351 Dishevelled_protein_dom
IPR001158 DIX
IPR038207 DIX_dom_sf
IPR015506 Dsh/Dvl-rel
IPR008341 DVL2
IPR001478 PDZ
IPR036034 PDZ_sf
PANTHERiPTHR10878 PTHR10878, 1 hit
PTHR10878:SF8 PTHR10878:SF8, 1 hit
PfamiView protein in Pfam
PF02377 Dishevelled, 1 hit
PF00778 DIX, 1 hit
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50841 DIX, 1 hit
PS50106 PDZ, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

I3L0M7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRVVKEEIS DDNARLPCFN GRVVSWLVSS DNPQPEMAPP VHEPRAELAP
60 70 80 90 100
PAPPLPPLPP ERTSGIGDSR PPSFHPNVSS SHENLEPETE TESVVSLRRE
110 120 130 140 150
RPRRRDSTGG HRTGGPSRLE RHLAGYESSS TLMTSELEST SLGDSDEEDT
160 170 180 190 200
MSRFSSSTEQ SSASRLLKRH RRRRKQRPPR LERTSSFSSV TDSTMSLNII
210 220 230 240 250
TVTLNMEKYN FLGISIVGQS NERGDGGIYI GSIMKGGAVA ADGRIEPGDM
260 270 280 290
LLQVNDMNFE NMSNDDAVRV LRDIVHKPGP IVLTVAKCWD P
Length:291
Mass (Da):32,137
Last modified:July 11, 2012 - v1
Checksum:iF90F059FEE00CAE0
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O14641DVL2_HUMAN
Segment polarity protein dishevelle...
DVL2
736Annotation score:
I3L2N2I3L2N2_HUMAN
Segment polarity protein dishevelle...
DVL2
730Annotation score:
I3L0Z8I3L0Z8_HUMAN
Segment polarity protein dishevelle...
DVL2
300Annotation score:
I3L2W9I3L2W9_HUMAN
Segment polarity protein dishevelle...
DVL2
363Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei291Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120057 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000574143; ENSP00000458209; ENSG00000004975
UCSCiuc060akb.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120057 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliI3L0M7
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiI3L0M7
PeptideAtlasiI3L0M7
PRIDEiI3L0M7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000574143; ENSP00000458209; ENSG00000004975
UCSCiuc060akb.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000004975.11
HGNCiHGNC:3086 DVL2
OpenTargetsiENSG00000004975
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3571 Eukaryota
ENOG410Y5G4 LUCA
GeneTreeiENSGT00390000013552

Miscellaneous databases

ChiTaRSiDVL2 human

Gene expression databases

BgeeiENSG00000004975 Expressed in 220 organ(s), highest expression level in vagina
ExpressionAtlasiI3L0M7 baseline and differential

Family and domain databases

Gene3Di3.10.20.380, 1 hit
InterProiView protein in InterPro
IPR003351 Dishevelled_protein_dom
IPR001158 DIX
IPR038207 DIX_dom_sf
IPR015506 Dsh/Dvl-rel
IPR008341 DVL2
IPR001478 PDZ
IPR036034 PDZ_sf
PANTHERiPTHR10878 PTHR10878, 1 hit
PTHR10878:SF8 PTHR10878:SF8, 1 hit
PfamiView protein in Pfam
PF02377 Dishevelled, 1 hit
PF00778 DIX, 1 hit
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50841 DIX, 1 hit
PS50106 PDZ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiI3L0M7_HUMAN
AccessioniPrimary (citable) accession number: I3L0M7
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: September 12, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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