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Entry version 44 (05 Jun 2019)
Sequence version 1 (11 Jul 2012)
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Protein
Submitted name:

ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)

Gene
N/A
Organism
Oreochromis niloticus (Nile tilapia) (Tilapia nilotica)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOreochromis niloticus (Nile tilapia) (Tilapia nilotica)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8128 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaCichlomorphaeCichliformesCichlidaeAfrican cichlidsPseudocrenilabrinaeOreochrominiOreochromis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005207 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini688 – 877SEC7InterPro annotationAdd BLAST190

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni46 – 67DisorderedSequence analysisAdd BLAST22
Regioni218 – 324DisorderedSequence analysisAdd BLAST107
Regioni346 – 410DisorderedSequence analysisAdd BLAST65
Regioni631 – 684DisorderedSequence analysisAdd BLAST54
Regioni1561 – 1606DisorderedSequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi218 – 232PolyampholyteSequence analysisAdd BLAST15
Compositional biasi233 – 248PolarSequence analysisAdd BLAST16
Compositional biasi308 – 324PolyampholyteSequence analysisAdd BLAST17
Compositional biasi375 – 402PolarSequence analysisAdd BLAST28

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0929 Eukaryota
COG5307 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157108

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00171 Sec7, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1000.11, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR032629 DCB_dom
IPR015403 Sec7_C
IPR023394 Sec7_C_sf
IPR000904 Sec7_dom
IPR035999 Sec7_dom_sf
IPR032691 Sec7_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16213 DCB, 1 hit
PF09324 DUF1981, 1 hit
PF01369 Sec7, 1 hit
PF12783 Sec7_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00222 Sec7, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF48425 SSF48425, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50190 SEC7, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

I3K9S2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFEGKKTKNM FLTRALEKIL ADKEVKKAHH SQLRKACEVA LEEIKEESEK
60 70 80 90 100
LSPPGGDGKS GSSTLPPIKS KTNFIEADKY FLPFELACQS KCPRIVITSL
110 120 130 140 150
DCLQKLIAYG HLTGSAPDST APGKKLIDRI IETICACFQG PQTDEGVQLQ
160 170 180 190 200
IIKALLTAVT SQHIEIHEGT VLQAVRTCYN IYLASKNLIN QTTAKATLTQ
210 220 230 240 250
MLNVIFARME NQALQEAKQL ERERHRQHSP VTQHTEPDSA QHQTHIHSPA
260 270 280 290 300
KGPTREANGP LTPPTPSITE EKGENPDPEN GSEFCVAESE QTEADQATAA
310 320 330 340 350
AESAAAQKHA EAAEDEDRET PNYEEKAQEI VQSILQEVVN TVAGAATEGT
360 370 380 390 400
QSSLEDEGTV GSDSEHVHAN GIPGTPISAS FTPSLPDDRL SVSSNDTQES
410 420 430 440 450
GAAPGQPPGA KFSHILQKDA FLVFRSLCKL SMKPLSDGPP DPKSHELRSK
460 470 480 490 500
VLSLQLLLSI LQNAGPIFKT NEMFINAIKQ YLCVALSKNG VSSVPEVFEL
510 520 530 540 550
SLSIFLTLLS HFKTHLKMQI EVFFKEIFLY ILETSTSSYD HKWMVIQTLT
560 570 580 590 600
RICADAQSVV DIYVNYDCDL NAANIFERLV NDLSKIAQGR GGHELGITPQ
610 620 630 640 650
QELTLRKKGL ECLVSILKCM VEWSKDQYVN PNSQTSLGQE KPSEQESTES
660 670 680 690 700
KAPETINRYG SINSLDSTAS SGIGSYSTQM SGTDNPEQFE VLKQQKEIIE
710 720 730 740 750
QGIDLFNKKP KRGIQYLQEQ GMLGTTPEDL AQFLHQEERL DSTQVGEFLG
760 770 780 790 800
DNDRFNKEVM YAYVDQMDFQ GKDFVSALRM FLEGFRLPGE AQKIDRLMEK
810 820 830 840 850
FAARYLECNQ GQTLFASADT AYVLAYSIIM LTTDLHSPQV KNKMTKEQYI
860 870 880 890 900
KMNRGINDSK DLPEEYLSAI YDEIAGKKIA MKETKELTMK SNKQSVASEK
910 920 930 940 950
QRRLLYNLEM EQMAKTAKAL MEAVSHVQAP FTSATHLEHV RPMFKLAWTP
960 970 980 990 1000
FLAAFSVGLQ DCDDTEVASL CLEGIRCAIR IACIFSIQLE RDAYVQALAR
1010 1020 1030 1040 1050
FTLLTATSGI AEMKQKNIDT IKTLITVAHT DGNYLGNSWL EILKCISQLE
1060 1070 1080 1090 1100
LAQLIGTGVK ARYISGTVRG KEGFIASTKE QSSDEYLGLV GGTVDRKQIA
1110 1120 1130 1140 1150
SIQESIGETS SQSVVVAVDR IFTGSTRLDG NAIVDFVRWL CAVSMDELAS
1160 1170 1180 1190 1200
PTHPRMFSLQ KIVEISYYNM GRIRLQWSRI WEVIGDHFNK VGCNPNEDVA
1210 1220 1230 1240 1250
IFAVDSLRQL SMKFLEKGEL ANFRFQKDFL RPFEHIMKKN RSPTIRDMVV
1260 1270 1280 1290 1300
RCIAQMVNSQ AANIRSGWKN IFSVFHLAAS DQDESIVELA FQTTGHIVTN
1310 1320 1330 1340 1350
VFEKHFAATI DSFQDAVKCL SEFACNASFP DTSMEAIRLI RHCAKYVSDR
1360 1370 1380 1390 1400
PQAFKDYTSD DMNVAPEDRV WVRGWFPILF ELSCIINRCK LDVRTRGLTV
1410 1420 1430 1440 1450
MFEVMKTYGH TFEKHWWQDL FRIVFRIFDN MKLPEQQTEK AEWMTTTCNH
1460 1470 1480 1490 1500
ALYAICDVFT QYFESLNGVL LDDILAQLYW CVQQDNEQLA RSGTNCLENV
1510 1520 1530 1540 1550
VILNGEKFSP ETWDKTCNCM LDIFKTTIPH ALLTWRPAGA EGEHLSTQSL
1560 1570 1580 1590 1600
PDKQLDSVSQ KSLDIQSRSD DQHSISSSDR AAMENRRQSQ YSSASGVTED
1610 1620 1630 1640 1650
GPRSRTQTKI QEQRLFSALL IKCVVQLELI QTIDNIVFFP ATSKKEDAEN
1660 1670 1680 1690 1700
FAAAQRDAVC SADVSVETQD QGMYRYLTSE QLFKLLDCLL DSHHFAKAFN
1710 1720 1730 1740 1750
SNNEQRTLLW KAGFKGKSKP NLLKQETSSL ACGLRILFRM YTDESRRDAW
1760 1770 1780 1790 1800
EEVQRRLLNV CSEAVAYFLA LTSESHREAW TNLLLLFLTK VLKISDERFK
1810 1820 1830 1840 1850
AHASRYYPLL CEIMQFDLIP ELRAILRKFY LRIGIVFNIA QLPEPEPQQA

RE
Length:1,852
Mass (Da):208,384
Last modified:July 11, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i618CF578B2E089A0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3K9S1I3K9S1_ORENI
ADP-ribosylation factor guanine nuc...
1,989Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AERX01010047 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSONIT00000017882; ENSONIP00000017867; ENSONIG00000014215

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AERX01010047 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSONIT00000017882; ENSONIP00000017867; ENSONIG00000014215

Phylogenomic databases

eggNOGiKOG0929 Eukaryota
COG5307 LUCA
GeneTreeiENSGT00940000157108

Family and domain databases

CDDicd00171 Sec7, 1 hit
Gene3Di1.10.1000.11, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR032629 DCB_dom
IPR015403 Sec7_C
IPR023394 Sec7_C_sf
IPR000904 Sec7_dom
IPR035999 Sec7_dom_sf
IPR032691 Sec7_N
PfamiView protein in Pfam
PF16213 DCB, 1 hit
PF09324 DUF1981, 1 hit
PF01369 Sec7, 1 hit
PF12783 Sec7_N, 1 hit
SMARTiView protein in SMART
SM00222 Sec7, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF48425 SSF48425, 1 hit
PROSITEiView protein in PROSITE
PS50190 SEC7, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI3K9S2_ORENI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: I3K9S2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: June 5, 2019
This is version 44 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
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