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Entry version 50 (05 Jun 2019)
Sequence version 1 (11 Jul 2012)
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Protein
Submitted name:

ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)

Gene
N/A
Organism
Oreochromis niloticus (Nile tilapia) (Tilapia nilotica)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOreochromis niloticus (Nile tilapia) (Tilapia nilotica)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8128 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaCichlomorphaeCichliformesCichlidaeAfrican cichlidsPseudocrenilabrinaeOreochrominiOreochromis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005207 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
8128.ENSONIP00000017866

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini809 – 998SEC7InterPro annotationAdd BLAST190

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni108 – 129DisorderedSequence analysisAdd BLAST22
Regioni280 – 420DisorderedSequence analysisAdd BLAST141
Regioni437 – 531DisorderedSequence analysisAdd BLAST95
Regioni752 – 805DisorderedSequence analysisAdd BLAST54
Regioni1682 – 1727DisorderedSequence analysisAdd BLAST46
Regioni1967 – 1989DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi280 – 294PolyampholyteSequence analysisAdd BLAST15
Compositional biasi295 – 310PolarSequence analysisAdd BLAST16
Compositional biasi326 – 340Pro-richSequence analysisAdd BLAST15
Compositional biasi350 – 370PolyampholyteSequence analysisAdd BLAST21
Compositional biasi400 – 417PolyampholyteSequence analysisAdd BLAST18
Compositional biasi496 – 523PolarSequence analysisAdd BLAST28

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0929 Eukaryota
COG5307 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157108

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
I3K9S1

Identification of Orthologs from Complete Genome Data

More...
OMAi
LLWNMEM

TreeFam database of animal gene trees

More...
TreeFami
TF300714

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00171 Sec7, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1000.11, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR032629 DCB_dom
IPR015403 Sec7_C
IPR023394 Sec7_C_sf
IPR000904 Sec7_dom
IPR035999 Sec7_dom_sf
IPR032691 Sec7_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16213 DCB, 1 hit
PF09324 DUF1981, 1 hit
PF01369 Sec7, 1 hit
PF12783 Sec7_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00222 Sec7, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF48425 SSF48425, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50190 SEC7, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

I3K9S1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNVQRKLGCR ATFISVLTPY CLTAAVLKRA LRLTLLKELH LCSRRLQPPL
60 70 80 90 100
GPGTPRSKFR CDMFEGKKTK NMFLTRALEK ILADKEVKKA HHSQLRKACE
110 120 130 140 150
VALEEIKEES EKLSPPGGDG KSGSSTLPPI KSKTNFIEAD KYFLPFELAC
160 170 180 190 200
QSKCPRIVIT SLDCLQKLIA YGHLTGSAPD STAPGKKLID RIIETICACF
210 220 230 240 250
QGPQTDEGVQ LQIIKALLTA VTSQHIEIHE GTVLQAVRTC YNIYLASKNL
260 270 280 290 300
INQTTAKATL TQMLNVIFAR MENQALQEAK QLERERHRQH SPVTQHTEPD
310 320 330 340 350
SAQHQTHIHS PAKGPTREAN GPLTPPTPSI TTPSTPSTPS TPAPESSGRS
360 370 380 390 400
APKEQEEQRE QEEKGENPDP ENGSEFCVAE SEQTEADQAT AAAESAAAQK
410 420 430 440 450
HAEAAEDEDR ETPNYEEKAQ EIVQSILQEV VNTVAGGHCL DPANLCSDTK
460 470 480 490 500
ESGGEGEPAE SEPAEAATEG TQSSLEDEGT VGSDSEHVHA NGIPGTPISA
510 520 530 540 550
SFTPSLPDDR LSVSSNDTQE SGAAPGQPPG AKFSHILQKD AFLVFRSLCK
560 570 580 590 600
LSMKPLSDGP PDPKSHELRS KVLSLQLLLS ILQNAGPIFK TNEMFINAIK
610 620 630 640 650
QYLCVALSKN GVSSVPEVFE LSLSIFLTLL SHFKTHLKMQ IEVFFKEIFL
660 670 680 690 700
YILETSTSSY DHKWMVIQTL TRICADAQSV VDIYVNYDCD LNAANIFERL
710 720 730 740 750
VNDLSKIAQG RGGHELGITP QQELTLRKKG LECLVSILKC MVEWSKDQYV
760 770 780 790 800
NPNSQTSLGQ EKPSEQESTE SKAPETINRY GSINSLDSTA SSGIGSYSTQ
810 820 830 840 850
MSGTDNPEQF EVLKQQKEII EQGIDLFNKK PKRGIQYLQE QGMLGTTPED
860 870 880 890 900
LAQFLHQEER LDSTQVGEFL GDNDRFNKEV MYAYVDQMDF QGKDFVSALR
910 920 930 940 950
MFLEGFRLPG EAQKIDRLME KFAARYLECN QGQTLFASAD TAYVLAYSII
960 970 980 990 1000
MLTTDLHSPQ VKNKMTKEQY IKMNRGINDS KDLPEEYLSA IYDEIAGKKI
1010 1020 1030 1040 1050
AMKETKELTM KSNKQSVASE KQRRLLYNLE MEQMAKTAKA LMEAVSHVQA
1060 1070 1080 1090 1100
PFTSATHLEH VRPMFKLAWT PFLAAFSVGL QDCDDTEVAS LCLEGIRCAI
1110 1120 1130 1140 1150
RIACIFSIQL ERDAYVQALA RFTLLTATSG IAEMKQKNID TIKTLITVAH
1160 1170 1180 1190 1200
TDGNYLGNSW LEILKCISQL ELAQLIGTGV KARYISGTVR GKEGFIASTK
1210 1220 1230 1240 1250
EQSSDEYLGL VGGTVDRKQI ASIQESIGET SSQSVVVAVD RIFTGSTRLD
1260 1270 1280 1290 1300
GNAIVDFVRW LCAVSMDELA SPTHPRMFSL QKIVEISYYN MGRIRLQWSR
1310 1320 1330 1340 1350
IWEVIGDHFN KVGCNPNEDV AIFAVDSLRQ LSMKFLEKGE LANFRFQKDF
1360 1370 1380 1390 1400
LRPFEHIMKK NRSPTIRDMV VRCIAQMVNS QAANIRSGWK NIFSVFHLAA
1410 1420 1430 1440 1450
SDQDESIVEL AFQTTGHIVT NVFEKHFAAT IDSFQDAVKC LSEFACNASF
1460 1470 1480 1490 1500
PDTSMEAIRL IRHCAKYVSD RPQAFKDYTS DDMNVAPEDR VWVRGWFPIL
1510 1520 1530 1540 1550
FELSCIINRC KLDVRTRGLT VMFEVMKTYG HTFEKHWWQD LFRIVFRIFD
1560 1570 1580 1590 1600
NMKLPEQQTE KAEWMTTTCN HALYAICDVF TQYFESLNGV LLDDILAQLY
1610 1620 1630 1640 1650
WCVQQDNEQL ARSGTNCLEN VVILNGEKFS PETWDKTCNC MLDIFKTTIP
1660 1670 1680 1690 1700
HALLTWRPAG AEGEHLSTQS LPDKQLDSVS QKSLDIQSRS DDQHSISSSD
1710 1720 1730 1740 1750
RAAMENRRQS QYSSASGVTE DGPRSRTQTK IQEQRLFSAL LIKCVVQLEL
1760 1770 1780 1790 1800
IQTIDNIVFF PATSKKEDAE NFAAAQRDAV CSADVSVETQ DQGMYRYLTS
1810 1820 1830 1840 1850
EQLFKLLDCL LDSHHFAKAF NSNNEQRTLL WKAGFKGKSK PNLLKQETSS
1860 1870 1880 1890 1900
LACGLRILFR MYTDESRRDA WEEVQRRLLN VCSEAVAYFL ALTSESHREA
1910 1920 1930 1940 1950
WTNLLLLFLT KVLKISDERF KAHASRYYPL LCEIMQFDLI PELRAILRKF
1960 1970 1980
YLRIGIVFNI AQLPEPEPQQ AREPETDMEV GEEAGEEAQ
Length:1,989
Mass (Da):223,170
Last modified:July 11, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4340CE02F0CB0178
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3K9S2I3K9S2_ORENI
ADP-ribosylation factor guanine nuc...
1,852Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AERX01010047 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSONIT00000017881; ENSONIP00000017866; ENSONIG00000014215

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AERX01010047 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi8128.ENSONIP00000017866

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSONIT00000017881; ENSONIP00000017866; ENSONIG00000014215

Phylogenomic databases

eggNOGiKOG0929 Eukaryota
COG5307 LUCA
GeneTreeiENSGT00940000157108
InParanoidiI3K9S1
OMAiLLWNMEM
TreeFamiTF300714

Family and domain databases

CDDicd00171 Sec7, 1 hit
Gene3Di1.10.1000.11, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR032629 DCB_dom
IPR015403 Sec7_C
IPR023394 Sec7_C_sf
IPR000904 Sec7_dom
IPR035999 Sec7_dom_sf
IPR032691 Sec7_N
PfamiView protein in Pfam
PF16213 DCB, 1 hit
PF09324 DUF1981, 1 hit
PF01369 Sec7, 1 hit
PF12783 Sec7_N, 1 hit
SMARTiView protein in SMART
SM00222 Sec7, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF48425 SSF48425, 1 hit
PROSITEiView protein in PROSITE
PS50190 SEC7, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI3K9S1_ORENI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: I3K9S1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: June 5, 2019
This is version 50 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
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