Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Cholinergic receptor, nicotinic, gamma

Gene
N/A
Organism
Oreochromis niloticus (Nile tilapia) (Tilapia nilotica)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotation
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Cholinergic receptor, nicotinic, gammaImported
OrganismiOreochromis niloticus (Nile tilapia) (Tilapia nilotica)Imported
Taxonomic identifieri8128 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaCichlomorphaeCichliformesCichlidaeAfrican cichlidsPseudocrenilabrinaeOreochrominiOreochromis
Proteomesi
  • UP000005207 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei243 – 266HelicalSequence analysisAdd BLAST24
Transmembranei278 – 297HelicalSequence analysisAdd BLAST20
Transmembranei309 – 330HelicalSequence analysisAdd BLAST22
Transmembranei478 – 500HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_500367364519 – 520Sequence analysisAdd BLAST502

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi8128.ENSONIP00000012678

Structurei

3D structure databases

ProteinModelPortaliI3JUY3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 242Neur_chan_LBDInterPro annotationAdd BLAST220
Domaini249 – 495Neur_chan_membInterPro annotationAdd BLAST247

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00910000144023
InParanoidiI3JUY3
OMAiCNLIARA
OrthoDBiEOG091G0R20

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

I3JUY3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LNQTALPWLF MFLCAASAAN LERELFKDLM KGYNKNVRPM EKSGDITKVS
60 70 80 90 100
IKMTLTNLIS LNEKEEALTT NVWIEMQWCD YRLRWDQPPR SALYGNITSS
110 120 130 140 150
LRVPSKSIWL PDIVLENNID GQFEVALYCN ALVSPDGCVY WLPPAIYHSA
160 170 180 190 200
CAITVNYFPF DWQNCTMVFR SQTYSANEIE LVLTKEDDIT LEWVDIDPEA
210 220 230 240 250
FTENGEWVIR HRPAKKVINT QYTKDDLEYQ ELVFFLIIQR KPVFYIINII
260 270 280 290 300
APCVLFSSLG LLVYYLPAKA GGQKCTMSIV TLLGQTVFLF LIAKKVPETS
310 320 330 340 350
QAVPLIGKYL MFVMSVTTMV VMNSVVVLNV SLRTPNTHKM ADKVRKIFLN
360 370 380 390 400
ILPRLLRMQM QPWTQNASNA SEMRNGTVSA GSVITKAEEY VMKTARSELM
410 420 430 440 450
FDKLRGRNGL MKSVLEKLHD GLEGGTAHHL VNSLAKASPE LKQCVASCKH
460 470 480 490 500
IAETTRQQND FQSENEEWFL VARVIDRVCF IVMVLVFFIG TIGIFLMGHF
510 520
NQPPATPFPG DPKKYLPPLH
Length:520
Mass (Da):59,151
Last modified:July 11, 2012 - v1
Checksum:iAC8B2795ADBC53BD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3JUY2I3JUY2_ORENI
Cholinergic receptor, nicotinic, ga...
519Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AERX01001167 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSONIT00000012688; ENSONIP00000012678; ENSONIG00000010081

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AERX01001167 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliI3JUY3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8128.ENSONIP00000012678

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSONIT00000012688; ENSONIP00000012678; ENSONIG00000010081

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00910000144023
InParanoidiI3JUY3
OMAiCNLIARA
OrthoDBiEOG091G0R20

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiI3JUY3_ORENI
AccessioniPrimary (citable) accession number: I3JUY3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: November 7, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again