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Protein
Submitted name:

Thrombospondin 2a

Gene

thbs2

Organism
Oreochromis niloticus (Nile tilapia) (Tilapia nilotica)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalciumPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Thrombospondin 2aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:thbs2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOreochromis niloticus (Nile tilapia) (Tilapia nilotica)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8128 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaCichlomorphaeCichliformesCichlidaeAfrican cichlidsPseudocrenilabrinaeOreochrominiOreochromis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005207 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500367303120 – 1185Sequence analysisAdd BLAST1166

Keywords - PTMi

Disulfide bondSAAS annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
8128.ENSONIP00000012323

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini323 – 380VWFCInterPro annotationAdd BLAST58
Domaini553 – 593EGF-likeInterPro annotationAdd BLAST41
Domaini652 – 694EGF-likeInterPro annotationAdd BLAST43
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati697 – 732TSP type-3PROSITE-ProRule annotationAdd BLAST36
Repeati733 – 768TSP type-3PROSITE-ProRule annotationAdd BLAST36
Repeati769 – 791TSP type-3PROSITE-ProRule annotationAdd BLAST23
Repeati792 – 827TSP type-3PROSITE-ProRule annotationAdd BLAST36
Repeati828 – 850TSP type-3PROSITE-ProRule annotationAdd BLAST23
Repeati851 – 888TSP type-3PROSITE-ProRule annotationAdd BLAST38
Repeati889 – 924TSP type-3PROSITE-ProRule annotationAdd BLAST36
Repeati925 – 960TSP type-3PROSITE-ProRule annotationAdd BLAST36
Domaini964 – 1178TSP C-terminalInterPro annotationAdd BLAST215

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFQQ Eukaryota
ENOG410XQKE LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157846

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
I3JTX8

Identification of Orthologs from Complete Genome Data

More...
OMAi
KEGFFLT

Database of Orthologous Groups

More...
OrthoDBi
120983at2759

TreeFam database of animal gene trees

More...
TreeFami
TF324917

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 3 hits
4.10.1080.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR000742 EGF-like_dom
IPR024731 EGF_dom
IPR001791 Laminin_G
IPR037349 Thrombospondin
IPR003367 Thrombospondin_3-like_rpt
IPR017897 Thrombospondin_3_rpt
IPR008859 Thrombospondin_C
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR015455 TSP2
IPR028974 TSP_type-3_rpt
IPR001007 VWF_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10199 PTHR10199, 2 hits
PTHR10199:SF10 PTHR10199:SF10, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12947 EGF_3, 1 hit
PF00090 TSP_1, 3 hits
PF02412 TSP_3, 7 hits
PF05735 TSP_C, 1 hit
PF00093 VWC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 3 hits
SM00179 EGF_CA, 2 hits
SM00209 TSP1, 3 hits
SM00210 TSPN, 1 hit
SM00214 VWC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103647 SSF103647, 3 hits
SSF49899 SSF49899, 2 hits
SSF82895 SSF82895, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50026 EGF_3, 2 hits
PS50092 TSP1, 3 hits
PS51234 TSP3, 8 hits
PS51236 TSP_CTER, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

I3JTX8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MILRRSLFLL LLSFNYLQAL TEDGEQEDET SFDLFEISDI TRRTLGAKQF
60 70 80 90 100
RGQNLDAPAY RFIRFDHLPP VSPPILKQIL RQIQNNEGFV FVASIRQDRS
110 120 130 140 150
SRGTLIGLEG PDGRRQFEIL SNGRANTLDL VYWADGSQNV VSFEDVDLSD
160 170 180 190 200
SQWKNITLHV HGENANLFVG CSLIDSFILD EPFYEHLKAE GSRMYVAKGS
210 220 230 240 250
IRENHFRGLL QSVRFIFDTS IEDILLSRDC EITKQDDANI VSESGEIVDV
260 270 280 290 300
SPSITTNVIG QKTDDVGAEM CERSCEELSI MFQELKGLRI VVSNLIDGLQ
310 320 330 340 350
KVTEENSVMK EALGRMKNSS EKNMCWQDGR LFDDKEDWVV DSCTKCTCQE
360 370 380 390 400
SKIVCHQITC PPVACASPSF IDGECCPACL PMDSDDGWSP WSEWTECTVT
410 420 430 440 450
CGIGTQQRGR SCDATSNPCT GPSIQTRKCS LGKCDSRVRQ DGGWSLWSPW
460 470 480 490 500
SSCSVTCGEG QITRIRHCNA PVPQLGGRDC EGSGRETQGC TAKPCPIDGG
510 520 530 540 550
WGPWSPWATC SATCGGGHKS RSRECNSPEP QYGGKKCFGE AVDRDSCNKN
560 570 580 590 600
DCPIDGCLSN PCFAGVDCSS SADGSWECGP CPAGFRGNGT HCEDINECDM
610 620 630 640 650
VSDVCYKVNG MQRCVNTDPG FHCLPCPKRY KGTQPFGMGV EAAKKNKQVC
660 670 680 690 700
EPENPCKDRT HNCHKYAECI YISHFSDPMY KCECRTGYAG DGFICGEDSD
710 720 730 740 750
LDGWPNQNLV CGANATYHCK KDNCPSLPNS GQEDFDRDGQ GDACDKDDDN
760 770 780 790 800
DGILDERDNC PLLYNPRQFD FDKDEVGDRC DNCPYEHNPA QIDTDHNGEG
810 820 830 840 850
DACAVDIDGD GILNENDNCP YVYNNDQKDT DMDGVGDQCD NCPLLHNPDQ
860 870 880 890 900
TDLDNDLVGD QCDNNQDIDE DGHQNNLDNC PYVANSNQAD HDKDGKGDAC
910 920 930 940 950
DYDDDNDGIP DDRDNCRLTP NEDQEDSDGD GRGDACKDDF DNDSIPDFLD
960 970 980 990 1000
VCPENNAISV TDFRKFQMVH LDPKGTTQID PNWVVRHQGK ELVQTANSDP
1010 1020 1030 1040 1050
GIAVGFDEFS AVDFSGTMYV NTDRDDDYAG FVFSYQSSGR FYVVMWKQIT
1060 1070 1080 1090 1100
QTYWEDKPSK AFGISGVSLK VVNSTTGTGE YLRNALWHTG NTPGQVRTLW
1110 1120 1130 1140 1150
HDPKNIGWKD YTAYRWHLIH RPKTGFIRVV VYEGKQIMAD SGPIYDKTFA
1160 1170 1180
GGRLGLFVFS QELVFFSDLK YECRDKPELP TVLTR
Length:1,185
Mass (Da):131,907
Last modified:July 11, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFAA50D8E8A019E8F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AERX01006402 Genomic DNA No translation available.
AERX01006403 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_005474097.1, XM_005474040.3
XP_005474098.1, XM_005474041.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSONIT00000012332; ENSONIP00000012323; ENSONIG00000009805

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100701440

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AERX01006402 Genomic DNA No translation available.
AERX01006403 Genomic DNA No translation available.
RefSeqiXP_005474097.1, XM_005474040.3
XP_005474098.1, XM_005474041.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi8128.ENSONIP00000012323

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSONIT00000012332; ENSONIP00000012323; ENSONIG00000009805
GeneIDi100701440

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7058

Phylogenomic databases

eggNOGiENOG410IFQQ Eukaryota
ENOG410XQKE LUCA
GeneTreeiENSGT00940000157846
InParanoidiI3JTX8
OMAiKEGFFLT
OrthoDBi120983at2759
TreeFamiTF324917

Family and domain databases

Gene3Di2.20.100.10, 3 hits
4.10.1080.10, 2 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR000742 EGF-like_dom
IPR024731 EGF_dom
IPR001791 Laminin_G
IPR037349 Thrombospondin
IPR003367 Thrombospondin_3-like_rpt
IPR017897 Thrombospondin_3_rpt
IPR008859 Thrombospondin_C
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR015455 TSP2
IPR028974 TSP_type-3_rpt
IPR001007 VWF_dom
PANTHERiPTHR10199 PTHR10199, 2 hits
PTHR10199:SF10 PTHR10199:SF10, 2 hits
PfamiView protein in Pfam
PF12947 EGF_3, 1 hit
PF00090 TSP_1, 3 hits
PF02412 TSP_3, 7 hits
PF05735 TSP_C, 1 hit
PF00093 VWC, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00179 EGF_CA, 2 hits
SM00209 TSP1, 3 hits
SM00210 TSPN, 1 hit
SM00214 VWC, 1 hit
SUPFAMiSSF103647 SSF103647, 3 hits
SSF49899 SSF49899, 2 hits
SSF82895 SSF82895, 3 hits
PROSITEiView protein in PROSITE
PS50026 EGF_3, 2 hits
PS50092 TSP1, 3 hits
PS51234 TSP3, 8 hits
PS51236 TSP_CTER, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI3JTX8_ORENI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: I3JTX8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: January 16, 2019
This is version 50 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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