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Protein
Submitted name:

Thrombospondin 2a

Gene

thbs2

Organism
Oreochromis niloticus (Nile tilapia) (Tilapia nilotica)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalciumPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Thrombospondin 2aImported
Gene namesi
Name:thbs2Imported
OrganismiOreochromis niloticus (Nile tilapia) (Tilapia nilotica)Imported
Taxonomic identifieri8128 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaCichlomorphaeCichliformesCichlidaeAfrican cichlidsPseudocrenilabrinaeOreochrominiOreochromis
Proteomesi
  • UP000005207 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500367303120 – 1185Sequence analysisAdd BLAST1166

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi8128.ENSONIP00000012323

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini323 – 380VWFCInterPro annotationAdd BLAST58
Domaini553 – 593EGF-likeInterPro annotationAdd BLAST41
Domaini652 – 694EGF-likeInterPro annotationAdd BLAST43
Repeati697 – 732TSP type-3PROSITE-ProRule annotationAdd BLAST36
Repeati733 – 768TSP type-3PROSITE-ProRule annotationAdd BLAST36
Repeati769 – 791TSP type-3PROSITE-ProRule annotationAdd BLAST23
Repeati792 – 827TSP type-3PROSITE-ProRule annotationAdd BLAST36
Repeati828 – 850TSP type-3PROSITE-ProRule annotationAdd BLAST23
Repeati851 – 888TSP type-3PROSITE-ProRule annotationAdd BLAST38
Repeati889 – 924TSP type-3PROSITE-ProRule annotationAdd BLAST36
Repeati925 – 960TSP type-3PROSITE-ProRule annotationAdd BLAST36
Domaini964 – 1178TSP C-terminalInterPro annotationAdd BLAST215

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IFQQ Eukaryota
ENOG410XQKE LUCA
GeneTreeiENSGT00850000132273
InParanoidiI3JTX8
OMAiTEKQVCE
OrthoDBiEOG091G00TV
TreeFamiTF324917

Family and domain databases

Gene3Di2.20.100.10, 3 hits
4.10.1080.10, 2 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR000742 EGF-like_dom
IPR024731 EGF_dom
IPR001791 Laminin_G
IPR037349 Thrombospondin
IPR003367 Thrombospondin_3-like_rpt
IPR017897 Thrombospondin_3_rpt
IPR008859 Thrombospondin_C
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR015455 TSP2
IPR028974 TSP_type-3_rpt
IPR001007 VWF_dom
PANTHERiPTHR10199 PTHR10199, 2 hits
PTHR10199:SF10 PTHR10199:SF10, 2 hits
PfamiView protein in Pfam
PF12947 EGF_3, 1 hit
PF00090 TSP_1, 3 hits
PF02412 TSP_3, 7 hits
PF05735 TSP_C, 1 hit
PF00093 VWC, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00179 EGF_CA, 2 hits
SM00209 TSP1, 3 hits
SM00210 TSPN, 1 hit
SM00214 VWC, 1 hit
SUPFAMiSSF103647 SSF103647, 3 hits
SSF49899 SSF49899, 2 hits
SSF82895 SSF82895, 3 hits
PROSITEiView protein in PROSITE
PS50026 EGF_3, 2 hits
PS50092 TSP1, 3 hits
PS51234 TSP3, 8 hits
PS51236 TSP_CTER, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

Sequencei

Sequence statusi: Complete.

I3JTX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILRRSLFLL LLSFNYLQAL TEDGEQEDET SFDLFEISDI TRRTLGAKQF
60 70 80 90 100
RGQNLDAPAY RFIRFDHLPP VSPPILKQIL RQIQNNEGFV FVASIRQDRS
110 120 130 140 150
SRGTLIGLEG PDGRRQFEIL SNGRANTLDL VYWADGSQNV VSFEDVDLSD
160 170 180 190 200
SQWKNITLHV HGENANLFVG CSLIDSFILD EPFYEHLKAE GSRMYVAKGS
210 220 230 240 250
IRENHFRGLL QSVRFIFDTS IEDILLSRDC EITKQDDANI VSESGEIVDV
260 270 280 290 300
SPSITTNVIG QKTDDVGAEM CERSCEELSI MFQELKGLRI VVSNLIDGLQ
310 320 330 340 350
KVTEENSVMK EALGRMKNSS EKNMCWQDGR LFDDKEDWVV DSCTKCTCQE
360 370 380 390 400
SKIVCHQITC PPVACASPSF IDGECCPACL PMDSDDGWSP WSEWTECTVT
410 420 430 440 450
CGIGTQQRGR SCDATSNPCT GPSIQTRKCS LGKCDSRVRQ DGGWSLWSPW
460 470 480 490 500
SSCSVTCGEG QITRIRHCNA PVPQLGGRDC EGSGRETQGC TAKPCPIDGG
510 520 530 540 550
WGPWSPWATC SATCGGGHKS RSRECNSPEP QYGGKKCFGE AVDRDSCNKN
560 570 580 590 600
DCPIDGCLSN PCFAGVDCSS SADGSWECGP CPAGFRGNGT HCEDINECDM
610 620 630 640 650
VSDVCYKVNG MQRCVNTDPG FHCLPCPKRY KGTQPFGMGV EAAKKNKQVC
660 670 680 690 700
EPENPCKDRT HNCHKYAECI YISHFSDPMY KCECRTGYAG DGFICGEDSD
710 720 730 740 750
LDGWPNQNLV CGANATYHCK KDNCPSLPNS GQEDFDRDGQ GDACDKDDDN
760 770 780 790 800
DGILDERDNC PLLYNPRQFD FDKDEVGDRC DNCPYEHNPA QIDTDHNGEG
810 820 830 840 850
DACAVDIDGD GILNENDNCP YVYNNDQKDT DMDGVGDQCD NCPLLHNPDQ
860 870 880 890 900
TDLDNDLVGD QCDNNQDIDE DGHQNNLDNC PYVANSNQAD HDKDGKGDAC
910 920 930 940 950
DYDDDNDGIP DDRDNCRLTP NEDQEDSDGD GRGDACKDDF DNDSIPDFLD
960 970 980 990 1000
VCPENNAISV TDFRKFQMVH LDPKGTTQID PNWVVRHQGK ELVQTANSDP
1010 1020 1030 1040 1050
GIAVGFDEFS AVDFSGTMYV NTDRDDDYAG FVFSYQSSGR FYVVMWKQIT
1060 1070 1080 1090 1100
QTYWEDKPSK AFGISGVSLK VVNSTTGTGE YLRNALWHTG NTPGQVRTLW
1110 1120 1130 1140 1150
HDPKNIGWKD YTAYRWHLIH RPKTGFIRVV VYEGKQIMAD SGPIYDKTFA
1160 1170 1180
GGRLGLFVFS QELVFFSDLK YECRDKPELP TVLTR
Length:1,185
Mass (Da):131,907
Last modified:July 11, 2012 - v1
Checksum:iFAA50D8E8A019E8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AERX01006402 Genomic DNA No translation available.
AERX01006403 Genomic DNA No translation available.
RefSeqiXP_005474097.1, XM_005474040.3
XP_005474098.1, XM_005474041.3

Genome annotation databases

EnsembliENSONIT00000012332; ENSONIP00000012323; ENSONIG00000009805
GeneIDi100701440

Similar proteinsi

Entry informationi

Entry nameiI3JTX8_ORENI
AccessioniPrimary (citable) accession number: I3JTX8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: July 18, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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