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Protein

Sodium channel protein

Gene
N/A
Organism
Oreochromis niloticus (Nile tilapia) (Tilapia nilotica)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi1765 – 1776PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotation
Biological processIon transport, Sodium transport, Transport
LigandCalciumPROSITE-ProRule annotation, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
OrganismiOreochromis niloticus (Nile tilapia) (Tilapia nilotica)Imported
Taxonomic identifieri8128 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaCichlomorphaeCichliformesCichlidaeAfrican cichlidsPseudocrenilabrinaeOreochrominiOreochromis
Proteomesi
  • UP000005207 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei156 – 180HelicalUniRule annotationAdd BLAST25
Transmembranei192 – 219HelicalUniRule annotationAdd BLAST28
Transmembranei240 – 262HelicalUniRule annotationAdd BLAST23
Transmembranei393 – 418HelicalUniRule annotationAdd BLAST26
Transmembranei708 – 726HelicalUniRule annotationAdd BLAST19
Transmembranei738 – 767HelicalUniRule annotationAdd BLAST30
Transmembranei773 – 797HelicalUniRule annotationAdd BLAST25
Transmembranei818 – 843HelicalUniRule annotationAdd BLAST26
Transmembranei873 – 893HelicalUniRule annotationAdd BLAST21
Transmembranei905 – 929HelicalUniRule annotationAdd BLAST25
Transmembranei1181 – 1204HelicalUniRule annotationAdd BLAST24
Transmembranei1216 – 1236HelicalUniRule annotationAdd BLAST21
Transmembranei1248 – 1269HelicalUniRule annotationAdd BLAST22
Transmembranei1290 – 1316HelicalUniRule annotationAdd BLAST27
Transmembranei1374 – 1398HelicalUniRule annotationAdd BLAST25
Transmembranei1410 – 1435HelicalUniRule annotationAdd BLAST26
Transmembranei1493 – 1512HelicalUniRule annotationAdd BLAST20
Transmembranei1524 – 1545HelicalUniRule annotationAdd BLAST22
Transmembranei1551 – 1573HelicalUniRule annotationAdd BLAST23
Transmembranei1611 – 1639HelicalUniRule annotationAdd BLAST29
Transmembranei1718 – 1738HelicalUniRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi8128.ENSONIP00000009250

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1752 – 1787EF-handInterPro annotationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili434 – 462Sequence analysisAdd BLAST29

Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2301 Eukaryota
ENOG410XNP6 LUCA
GeneTreeiENSGT00830000128242
InParanoidiI3JK56
OrthoDBiEOG091G1DMM
TreeFamiTF323985

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR005821 Ion_trans_dom
IPR028817 Na_channel_a4suB
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037:SF186 PTHR10037:SF186, 2 hits
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PRINTSiPR00170 NACHANNEL
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit

Sequencei

Sequence statusi: Complete.

I3JK56-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSLLPPVGT EVFRRFTTAS QEVQQQHVAE AKERKTWKDK WVTEKNLPKP
60 70 80 90 100
AAHLETGKSL PLIYGDPPPQ LLNTPLEDLD PFYQSRKTFV VLSKGNIINR
110 120 130 140 150
FSADSSCYLL SPFNPLRTLA IKTLLHPYPS VLIFTTLLQK HVVSCQHFWH
160 170 180 190 200
RVYSNYVYMA IFIFEALVKI VARGFCVGLF TFLRDPWNWL DIIIISTLLV
210 220 230 240 250
SQFIDLGKFA VLMTISLLYS QRGALFTGLK KTVEALVQSV KRLDCVIILT
260 270 280 290 300
VFCLSILAMI GLQLFMGTLK NKCVIWSMNT NTTEFDFHNH TTSPGMMVVP
310 320 330 340 350
YPDWQVFFQH YNESSENYYY IPGHPDPLVC GNQSDAERCP DGFNCVKAGS
360 370 380 390 400
NPNFGYTSYD SFFWSLMSLF RLMMHDFWEG LMQLTLRAAG KSYLIVFLLV
410 420 430 440 450
FFPGCFFLLS LILAVVVMTR AEQEEAQGAE AIQREEEFRR IVEVLKRREE
460 470 480 490 500
EEENNKSTLT ASTGIRRAMS SQILIKSNQI QFIGWSSVSV CTSLTAEFGS
510 520 530 540 550
LLWSIQVCAN NTTFSPGLGA APSKTQKQES MIHTRYRCNF FTSTQLTALS
560 570 580 590 600
SSTSVSRLSG SMATTKGRRT NANTGTLGPG VASVAKTCHS CTKCTGITRH
610 620 630 640 650
VTDPADLSAA DASVHLKSGC SKNLSPASSQ LIVQQASSRA ETPEQQDSLQ
660 670 680 690 700
KKKSAAGIQA TKQEHVEEAE EHHRPLCCTC TDAFLKGDCC GCWRWLKQQF
710 720 730 740 750
HTFITNPFFD LVIISCIIVS TIITAIEHYP MMVEFMETLV IAHLVFHGIF
760 770 780 790 800
AAEMIIKLVA LGLHGYFQVR WHIFDFILVI ISLVHLGLAD VEGLSLLRSF
810 820 830 840 850
LPFRVFRLAR WWPMLHMFLK IVWASVGNLT LVLFITVFMF SVAGVQLFQS
860 870 880 890 900
DYKANVCRIS YDCQLPRWHM EDFFHTFMLV FRVLCGQCLE YLWDCMEVSN
910 920 930 940 950
DGVCVTFFMI VLIVGKLLIL HLFLNLLFIN DQLVDSEDKT TNTLQRTMKQ
960 970 980 990 1000
TRTWIPKSIW TLWGSQLSSL IKTQRNTAKA AKARREGWQK VGDKLNSLEP
1010 1020 1030 1040 1050
QQDPLEHGAT KKRAEQIKTG GGPAPPRVCV PETGCLHTGS DCDSEGLCSL
1060 1070 1080 1090 1100
LTGSETKKDN KEEYLTLSSV SSDQLTLDDN HTNMAAWEAP VAVAEIEFRT
1110 1120 1130 1140 1150
PENAQEKETQ HVKTEISHPE FTDTCDVMQK LKDETHPEPE DCCCNRCYIC
1160 1170 1180 1190 1200
CPFLEIDTSQ GTGRVWSNFR RACLCIVQHK FFEGFIVFII LLSCAALVFE
1210 1220 1230 1240 1250
DIYLEHRPVL QRVLKMADLV FTFVFLVEML LKWIAFGFKK YFTSFWCWLD
1260 1270 1280 1290 1300
FLILNVTLFS LMGNMLGYTS QPLRALRTLR VPSRFKGMRV VLKVLAVTLP
1310 1320 1330 1340 1350
SMFSMLLVIL VIWLFFSVIG VNLFAGKFYY CYNETSEEIF SFNLVNNKTE
1360 1370 1380 1390 1400
CFSLMVMNFS EVNWKTWTFN FDNVGMGFLS LLIMGTSSGW MDIMYAAVDS
1410 1420 1430 1440 1450
TQPRYEINVY MYMYFICFII IGCFFTLNLF IRVIIDTIHQ QRLYFGGKHV
1460 1470 1480 1490 1500
FVTDQQQKYL NTIKKRFSEK RNNTIPRPQH CCLAWLFHLV TALYFEIFMV
1510 1520 1530 1540 1550
VVIFFNMVVL MVETDDQSME KSHVLHWIHF ILVAIFLVEF ILKIIALRQH
1560 1570 1580 1590 1600
YFRNGLHIVD FVVLTLSIIG LLLSDIFEKY FGSPSLFSVM RLGRLFALCG
1610 1620 1630 1640 1650
PFHHIRFARR IWMLIMGFVM SLPALFNIGL LFFLIVYTFS IIGMFNFAYV
1660 1670 1680 1690 1700
KNEMMIDDMF NFKTFGNSII SMTMITTSSG WDGLLSPIMN TPPDCDLRLP
1710 1720 1730 1740 1750
DPGNCANPTV GIVFFSSYIL LFCLLVIQLF IVVILELFNT ANPEDAEMLS
1760 1770 1780 1790 1800
DDHLQMFYET WRKFDPSGSQ VIQYSELADF CDGLQDPLRI PKPNTIKLTH
1810 1820 1830 1840
LNLPLLPGDQ ISCLDVLRTI TTQVFDEPAE VDALKAKLDE
Length:1,840
Mass (Da):210,067
Last modified:July 11, 2012 - v1
Checksum:iE40DEF99A1352DAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AERX01063454 Genomic DNA No translation available.
AERX01063455 Genomic DNA No translation available.
AERX01063456 Genomic DNA No translation available.
AERX01063457 Genomic DNA No translation available.
AERX01063458 Genomic DNA No translation available.
AERX01063459 Genomic DNA No translation available.
AERX01063460 Genomic DNA No translation available.
AERX01063461 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSONIT00000009255; ENSONIP00000009250; ENSONIG00000007334

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AERX01063454 Genomic DNA No translation available.
AERX01063455 Genomic DNA No translation available.
AERX01063456 Genomic DNA No translation available.
AERX01063457 Genomic DNA No translation available.
AERX01063458 Genomic DNA No translation available.
AERX01063459 Genomic DNA No translation available.
AERX01063460 Genomic DNA No translation available.
AERX01063461 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8128.ENSONIP00000009250

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSONIT00000009255; ENSONIP00000009250; ENSONIG00000007334

Phylogenomic databases

eggNOGiKOG2301 Eukaryota
ENOG410XNP6 LUCA
GeneTreeiENSGT00830000128242
InParanoidiI3JK56
OrthoDBiEOG091G1DMM
TreeFamiTF323985

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR005821 Ion_trans_dom
IPR028817 Na_channel_a4suB
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037:SF186 PTHR10037:SF186, 2 hits
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PRINTSiPR00170 NACHANNEL
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiI3JK56_ORENI
AccessioniPrimary (citable) accession number: I3JK56
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: May 23, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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