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Entry version 56 (12 Aug 2020)
Sequence version 2 (17 Jun 2020)
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Protein
Submitted name:

Uncharacterized protein

Gene

cbfa2t2

Organism
Oreochromis niloticus (Nile tilapia) (Tilapia nilotica)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressorARBA annotation
Biological processTranscription, Transcription regulationARBA annotation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cbfa2t2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOreochromis niloticus (Nile tilapia) (Tilapia nilotica)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8128 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaCichlomorphaeCichliformesCichlidaeAfrican cichlidsPseudocrenilabrinaeOreochrominiOreochromis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005207 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Linkage group LG5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    NucleusARBA annotation

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    8128.ENSONIP00000008575

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini89 – 184TAFHInterPro annotationAdd BLAST96
    Domaini486 – 522MYND-typeInterPro annotationAdd BLAST37

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 82DisorderedSequence analysisAdd BLAST82
    Regioni194 – 224DisorderedSequence analysisAdd BLAST31
    Regioni363 – 408DisorderedSequence analysisAdd BLAST46
    Regioni550 – 573DisorderedSequence analysisAdd BLAST24

    Coiled coil

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili425 – 472Sequence analysisAdd BLAST48

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi10 – 27PolarSequence analysisAdd BLAST18
    Compositional biasi34 – 82PolarSequence analysisAdd BLAST49
    Compositional biasi206 – 224PolyampholyteSequence analysisAdd BLAST19
    Compositional biasi384 – 398PolarSequence analysisAdd BLAST15

    Keywords - Domaini

    Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotation

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG502QTD6, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00950000183176

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_022077_2_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    I3JI81

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    HHATCNN

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF106303

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.20.120.1110, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR013289, CBFA2T1/2/3
    IPR014896, NHR2
    IPR037249, TAFH/NHR1_dom_sf
    IPR003894, TAFH_NHR1
    IPR002893, Znf_MYND

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR10379, PTHR10379, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF08788, NHR2, 1 hit
    PF07531, TAFH, 1 hit
    PF01753, zf-MYND, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR01875, ETOFAMILY

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00549, TAFH, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF158553, SSF158553, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51119, TAFH, 1 hit
    PS50865, ZF_MYND_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

    I3JI81-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MPGSPVDAKT HSRSAPSSSA SSTMPPLPSV NPSGPRPASF STTALTNGNH
    60 70 80 90 100
    HSPPTLNAVP SPPQRYSNGP SSSSSSSLAN QQLPATCGAR QLSKLKRFLT
    110 120 130 140 150
    TLQQFGNDIS PEIGDSVRSL VLALVNSTVT IEEFHSRLQE ATNFPLRPFV
    160 170 180 190 200
    IPFLKANLPL LQRELLHCAR AAKQTPAQYL SQHEHLLLST TLASSPDSSE
    210 220 230 240 250
    LLMEPPEPGT KRHSPSRAKE NGFHERPPVA MEPAAKRICT ISPAPRHSPA
    260 270 280 290 300
    HPLPLTAQLH PTPPPLQHYA LDDIAAPHIL HREHSQRVLE IRELKDRPRL
    310 320 330 340 350
    PGTNGGYREE PVDHRLTDRE WADEWRHLDH VLNCIVDMVE KTRRSVSVLR
    360 370 380 390 400
    RCQESDREEL NYWRRRSSEQ EDPRKGGPAS APFSKTHSPH SSESGGYHSQ
    410 420 430 440 450
    RDFAPRPGSA YVTDEIWRKA EEAVNEVKRQ AMEEVQKAVA EAEQKAFEMI
    460 470 480 490 500
    AAERAKMEKT LAEAKRKAQE DAIMVINEQE DSSECCWNCG RKASETCSGC
    510 520 530 540 550
    NAARYCGSFC QHKDWERHHL ICSPGLQAQP KPVSASRVAA VATAASAATV
    560 570
    KASVASRSST PSTPASAPET NGH
    Length:573
    Mass (Da):62,936
    Last modified:June 17, 2020 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B3A1C9CB1524428
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A669DC77A0A669DC77_ORENI
    TAFH domain-containing protein
    cbfa2t2
    211Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A669CH57A0A669CH57_ORENI
    Uncharacterized protein
    cbfa2t2
    612Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A669AXV8A0A669AXV8_ORENI
    Uncharacterized protein
    cbfa2t2
    578Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A669BCZ9A0A669BCZ9_ORENI
    Uncharacterized protein
    cbfa2t2
    533Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A669E3A6A0A669E3A6_ORENI
    Uncharacterized protein
    cbfa2t2
    590Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A669EUG6A0A669EUG6_ORENI
    Uncharacterized protein
    cbfa2t2
    581Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A669F6X8A0A669F6X8_ORENI
    Uncharacterized protein
    cbfa2t2
    629Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A669F8Q0A0A669F8Q0_ORENI
    Uncharacterized protein
    cbfa2t2
    586Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSONIT00000008580; ENSONIP00000008575; ENSONIG00000006794

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    STRINGi8128.ENSONIP00000008575

    Genome annotation databases

    EnsembliENSONIT00000008580; ENSONIP00000008575; ENSONIG00000006794

    Phylogenomic databases

    eggNOGiENOG502QTD6, Eukaryota
    GeneTreeiENSGT00950000183176
    HOGENOMiCLU_022077_2_0_1
    InParanoidiI3JI81
    OMAiHHATCNN
    TreeFamiTF106303

    Family and domain databases

    Gene3Di1.20.120.1110, 1 hit
    InterProiView protein in InterPro
    IPR013289, CBFA2T1/2/3
    IPR014896, NHR2
    IPR037249, TAFH/NHR1_dom_sf
    IPR003894, TAFH_NHR1
    IPR002893, Znf_MYND
    PANTHERiPTHR10379, PTHR10379, 1 hit
    PfamiView protein in Pfam
    PF08788, NHR2, 1 hit
    PF07531, TAFH, 1 hit
    PF01753, zf-MYND, 1 hit
    PRINTSiPR01875, ETOFAMILY
    SMARTiView protein in SMART
    SM00549, TAFH, 1 hit
    SUPFAMiSSF158553, SSF158553, 1 hit
    PROSITEiView protein in PROSITE
    PS51119, TAFH, 1 hit
    PS50865, ZF_MYND_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI3JI81_ORENI
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: I3JI81
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
    Last sequence update: June 17, 2020
    Last modified: August 12, 2020
    This is version 56 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteomeImported
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

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