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UniProtKB - I3IS91 (I3IS91_DANRE)

Entry version 48 (02 Dec 2020)
Sequence version 2 (13 Nov 2013)
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Protein
Submitted name:

CD109 molecule

Gene

cd109

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DRE-114608, Platelet degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CD109 moleculeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cd109Imported
Synonyms:si:zfos-875e8.2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-120215-253, cd109

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500367138019 – 1337Sequence analysisAdd BLAST1319

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSDARG00000060609, Expressed in gastrula and 12 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini503 – 633A2M_N_2InterPro annotationAdd BLAST131
Domaini727 – 817A2MInterPro annotationAdd BLAST91

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155926

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001634_5_3_1

Identification of Orthologs from Complete Genome Data

More...OMAi		EIKLFWS

Family and domain databases

Conserved Domains Database

More...CDDi		cd02897, A2M_2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 2 hits
2.60.40.690, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036595, A-macroglobulin_rcpt-bd_sf
IPR011625, A2M_N_BRD
IPR041813, A2M_TED
IPR011626, Alpha-macroglobulin_TED
IPR013783, Ig-like_fold
IPR001599, Macroglobln_a2
IPR019742, MacrogloblnA2_CS
IPR002890, MG2
IPR041555, MG3
IPR008930, Terpenoid_cyclase/PrenylTrfase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00207, A2M, 1 hit
PF07703, A2M_BRD, 1 hit
PF01835, MG2, 1 hit
PF17791, MG3, 1 hit
PF07678, TED_complement, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01360, A2M, 1 hit
SM01359, A2M_N_2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48239, SSF48239, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00477, ALPHA_2_MACROGLOBULIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

I3IS91-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEWLQFFGIL VCSLVCRGAM VTSSARQNLS YLISVSEVLR CGVPTTLSVT 
        60         70         80         90        100
VLSDYPINVT ARLTHGKTSV AQTQSTVPAG SSRLLSLPPV FYDDMTYWYP 
       110        120        130        140        150
YQLNVEGFSG THLVFSNSTS MVFSPRCMSI FIQTDKNYYQ PGQTVKFRVV 
       160        170        180        190        200
SVTPDGKPYS GRTDIFIRDP RGNMIRQWLA VDSFLGVISK ELNISQNPPL 
       210        220        230        240        250
GSWKITAGVN DVIHERAFTV DYYVLPRFEV KLDVPSVLYC EDTLMGTVTA 
       260        270        280        290        300
KYFYGKPVSG FMDVRFVHGF NGIEMRYDHT EMIEGSAEIT FDMKDFSTRF 
       310        320        330        340        350
NDYSYSYYDG YRPIEFIDVN VNITESATGL MYNSSARVSI VTEKYKLEFL 
       360        370        380        390        400
QYPHIVKPSM TFTAKLKLSL YDQRPLSAED QIESVYLAVT QHKLSPWTWM 
       410        420        430        440        450
WSDGGPLGPR MMNNTPSTSF PPNSDGGPLG PHMMNSTPPT SFTPIYDLPV 
       460        470        480        490        500
QNIELPVTAD GLMSFQIHLS DSVATLDLEA RFKDTVQHLQ LYRSYSSPSK 
       510        520        530        540        550
SYIQLHRDSE PQVGRSLNFT LESSFNLTKI HYLVTSRAGV VDAGTVQSSS 
       560        570        580        590        600
FSLNTDHLWA PQACVMVYYT LPDGEIVNDA LHVSFTKVLR NTVSVRWSQD 
       610        620        630        640        650
RAEPAESVSL SVSVSEPGSV LGILVVDKAT LNSAEDNGLS EKTVLEEFLS 
       660        670        680        690        700
YSREMTHTDN RGMKMGDPYS VFTACGVTVL TDARLNQEMA TNQEMFPMFP 
       710        720        730        740        750
GEEGLFMTAM PDSSIQEPRQ RKDFPETWIW LDANVSDSAS AVFSLTVPDS 
       760        770        780        790        800
LTSWAAFAII MSENLGLGIS APAELTVFRD FFMSLDLPAF LIRGELLLLE 
       810        820        830        840        850
VNLFNYMDVD LEVIVVVAES GMFEFVSTDS ADFSVANVRK VLVLSQNFTM 
       860        870        880        890        900
LLFPIKATTL GEIPISVKAT SVYSSDWLYK TVLVKPEGLQ QSFTQTLFLE 
       910        920        930        940        950
FLLQQHTLSR KMTFSFPADV VPNSQRASVS AVGDILGPSI GNLDSLIEMP 
       960        970        980        990       1000
YGCGEQNMIH FAPNTYVLQY LKSTKQAEEQ TRRKAMSYMM EAYERELSYQ 
      1010       1020       1030       1040       1050
RVDGSFSAFG DSDESGSTWL SAFVLRCFLQ ARDFISIEPL VMERTAFWLV 
      1060       1070       1080       1090       1100
AHQESDGSFR EPGQVIHTEL QGGLDGSVSL TAYVLIALLE DAKYESTHKD 
      1110       1120       1130       1140       1150
SVSLALSFLT SRLAQGISSN YSLSLVAYAL SLAKSSAAPS ALTTLLNRAL 
      1160       1170       1180       1190       1200
VIDGVPTWRS PGSVLYDSWQ PRSADIEIAA YVLLTMHSLR LMDEGFALMK 
      1210       1220       1230       1240       1250
WLSQQRNHLG GYGSTQDTVM ALHALSVYAT FSSAESMDLT IRVNEGSGTV 
      1260       1270       1280       1290       1300
ATFSIDKSNY LLQQSHDLPI ESKDGVDIEV EAEGTGFALF QLTVFYNVMN 
      1310       1320       1330 
VRRSLRRRDI HTDEAFYLYV DIMDKEEYHV NLYTCFR
Length:1,337
Mass (Da):149,422
Last modified:November 13, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i521801EB1C24C7C0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CU525921 Genomic DNA No translation available.
CU855808 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000151435; ENSDARP00000125759; ENSDARG00000060609

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU525921 Genomic DNA No translation available.
CU855808 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENSDART00000151435; ENSDARP00000125759; ENSDARG00000060609

Organism-specific databases

ZFINiZDB-GENE-120215-253, cd109

Phylogenomic databases

GeneTreeiENSGT00940000155926
HOGENOMiCLU_001634_5_3_1
OMAiEIKLFWS

Enzyme and pathway databases

ReactomeiR-DRE-114608, Platelet degranulation

Gene expression databases

BgeeiENSDARG00000060609, Expressed in gastrula and 12 other tissues

Family and domain databases

CDDicd02897, A2M_2, 1 hit
Gene3Di2.60.40.10, 2 hits
2.60.40.690, 1 hit
InterProiView protein in InterPro
IPR036595, A-macroglobulin_rcpt-bd_sf
IPR011625, A2M_N_BRD
IPR041813, A2M_TED
IPR011626, Alpha-macroglobulin_TED
IPR013783, Ig-like_fold
IPR001599, Macroglobln_a2
IPR019742, MacrogloblnA2_CS
IPR002890, MG2
IPR041555, MG3
IPR008930, Terpenoid_cyclase/PrenylTrfase
PfamiView protein in Pfam
PF00207, A2M, 1 hit
PF07703, A2M_BRD, 1 hit
PF01835, MG2, 1 hit
PF17791, MG3, 1 hit
PF07678, TED_complement, 1 hit
SMARTiView protein in SMART
SM01360, A2M, 1 hit
SM01359, A2M_N_2, 1 hit
SUPFAMiSSF48239, SSF48239, 1 hit
PROSITEiView protein in PROSITE
PS00477, ALPHA_2_MACROGLOBULIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI3IS91_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: I3IS91
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: November 13, 2013
Last modified: December 2, 2020
This is version 48 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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