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Entry version 39 (19 Jan 2022)
Sequence version 1 (11 Jul 2012)
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Protein

Histidine kinase

Gene

KSU1_C0101

Organism
Candidatus Jettenia caeni
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.123.2.13, the sweet, pq-loop, saliva, mtn3 (sweet) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histidine kinaseARBA annotation (EC:2.7.13.3ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:KSU1_C0101Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCandidatus Jettenia caeniImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri247490 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaPlanctomycetesCandidatus BrocadiaeCandidatus BrocadialesCandidatus BrocadiaceaeCandidatus Jettenia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002985 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 23HelicalSequence analysisAdd BLAST18
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Transmembranei61 – 82HelicalSequence analysisAdd BLAST22
Transmembranei102 – 121HelicalSequence analysisAdd BLAST20
Transmembranei405 – 425HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
247490.KSU1_C0101

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini427 – 479HAMPInterPro annotationAdd BLAST53
Domaini484 – 553PASInterPro annotationAdd BLAST70
Domaini558 – 610PACInterPro annotationAdd BLAST53
Domaini611 – 680PASInterPro annotationAdd BLAST70
Domaini685 – 728PACInterPro annotationAdd BLAST44

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG2202, Bacteria
COG4095, Bacteria
COG5000, Bacteria

Database of Orthologous Groups

More...
OrthoDBi
1377603at2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00130, PAS, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033479, dCache_1
IPR003660, HAMP_dom
IPR001610, PAC
IPR000014, PAS
IPR000700, PAS-assoc_C
IPR035965, PAS-like_dom_sf
IPR006603, PQ-loop_rpt
IPR029151, Sensor-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02743, dCache_1, 1 hit
PF00672, HAMP, 1 hit
PF13426, PAS_9, 2 hits
PF04193, PQ-loop, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00304, HAMP, 1 hit
SM00086, PAC, 2 hits
SM00091, PAS, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103190, SSF103190, 1 hit
SSF55785, SSF55785, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00229, sensory_box, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50885, HAMP, 1 hit
PS50113, PAC, 2 hits
PS50112, PAS, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

I3IJ02-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIWFLIGVIA AICSSIGFIP QIIQGIKTKS LSDVSPAMMT IVVVASSLWL
60 70 80 90 100
AYGIHIKNST IIFSNVSTLS FAIITLLLRF LFKPEFVQLK RKLLSIPIKN
110 120 130 140 150
RLILLLITFT LLPFVLLRIL AYPRIQADVQ EVLIRNLEGI VHKQAELVTN
160 170 180 190 200
WIYERVKNAR VIANNPLIAK GTEITKEDKD YPEIVQYLEE IKNEYGYKGI
210 220 230 240 250
MMSNNKGLVT VTTSGESIGR DILQTDYFHG AMQGDSFVSS IVPSEIPLIN
260 270 280 290 300
EYAEEELGIP TMFVSTPLKD KGGNITGVVA LRIDVSRLND VMLSLNLGKT
310 320 330 340 350
GKTYLVNKDG YMITESRFAG YLRDMGLIKK RCALELRVID RETGKVTQGV
360 370 380 390 400
QQCISGNNGF DAQGYKDYSD VTVLSAWRWL PKFHWGVIAE IDKDEGYGVA
410 420 430 440 450
YNLNYIVWGV LLILAFPFVM VAYLVGKKLS VPILKLTEVT KKMASGDLAQ
460 470 480 490 500
RVDIQREDEL GELASSFNVM AKSLDEKTKE IIISEKRYRE IFNSIKEGVY
510 520 530 540 550
QSDPGAEGVF TFINKAGAEI LGYSTPEEVI GTKVKHIYVD PEDRRRLCDK
560 570 580 590 600
LEKDGVWREF VSLCKRKSGE SFYAERTSSM LRDEKGNPAA IYGVFRDISE
610 620 630 640 650
RKKAEMEVIE SEKRYRLLFD SLKEGVYQSE PEVDGVFTWI NQAGAEILGY
660 670 680 690 700
KSPEEVIGLK VKDVYVNPDD RKELIDTLEK DGIWRSFILY CRRKNGERFI
710 720
SESTCNLVRD EAGKPVRIDG ILRDITER
Length:728
Mass (Da):82,349
Last modified:July 11, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i95747C5E415C30EC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BAFH01000003 Genomic DNA Translation: GAB61697.1

NCBI Reference Sequences

More...
RefSeqi
WP_007220815.1, NZ_BAFH01000003.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
GAB61697; GAB61697; KSU1_C0101

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BAFH01000003 Genomic DNA Translation: GAB61697.1
RefSeqiWP_007220815.1, NZ_BAFH01000003.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi247490.KSU1_C0101

Protein family/group databases

TCDBi2.A.123.2.13, the sweet, pq-loop, saliva, mtn3 (sweet) family

Genome annotation databases

EnsemblBacteriaiGAB61697; GAB61697; KSU1_C0101

Phylogenomic databases

eggNOGiCOG2202, Bacteria
COG4095, Bacteria
COG5000, Bacteria
OrthoDBi1377603at2

Family and domain databases

CDDicd00130, PAS, 2 hits
InterProiView protein in InterPro
IPR033479, dCache_1
IPR003660, HAMP_dom
IPR001610, PAC
IPR000014, PAS
IPR000700, PAS-assoc_C
IPR035965, PAS-like_dom_sf
IPR006603, PQ-loop_rpt
IPR029151, Sensor-like_sf
PfamiView protein in Pfam
PF02743, dCache_1, 1 hit
PF00672, HAMP, 1 hit
PF13426, PAS_9, 2 hits
PF04193, PQ-loop, 1 hit
SMARTiView protein in SMART
SM00304, HAMP, 1 hit
SM00086, PAC, 2 hits
SM00091, PAS, 2 hits
SUPFAMiSSF103190, SSF103190, 1 hit
SSF55785, SSF55785, 2 hits
TIGRFAMsiTIGR00229, sensory_box, 2 hits
PROSITEiView protein in PROSITE
PS50885, HAMP, 1 hit
PS50113, PAC, 2 hits
PS50112, PAS, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI3IJ02_9BACT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: I3IJ02
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: January 19, 2022
This is version 39 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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