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Entry version 41 (10 Feb 2021)
Sequence version 1 (11 Jul 2012)
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Protein

Peptidase S59 domain-containing protein

Gene

TBLA0A10170

Organism
Tetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 / UCD 77-7) (Yeast) (Kluyveromyces blattae)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peptidase S59 domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TBLA0A10170Imported
ORF Names:TBLA_0A10170Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 / UCD 77-7) (Yeast) (Kluyveromyces blattae)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1071380 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeTetrapisispora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002866 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nuclear pore complexARBA annotation, Nucleus

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
1071379.XP_004178315.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini995 – 1136Peptidase S59InterPro annotationAdd BLAST142

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 79DisorderedSequence analysisAdd BLAST79
Regioni190 – 229DisorderedSequence analysisAdd BLAST40
Regioni253 – 631DisorderedSequence analysisAdd BLAST379
Regioni822 – 844DisorderedSequence analysisAdd BLAST23
Regioni896 – 951DisorderedSequence analysisAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi909 – 928PolyampholyteSequence analysisAdd BLAST20
Compositional biasi929 – 947PolarSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nucleoporin GLFG family.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0845, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011051_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
I2GXE4

Database of Orthologous Groups

More...
OrthoDBi
1060706at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1610.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025574, Nucleoporin_FG_rpt
IPR037665, Nucleoporin_S59-like
IPR037637, NUP98-NUP96
IPR007230, Peptidase_S59
IPR036903, Peptidase_S59_sf

The PANTHER Classification System

More...
PANTHERi
PTHR23198, PTHR23198, 2 hits
PTHR23198:SF17, PTHR23198:SF17, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04096, Nucleoporin2, 1 hit
PF13634, Nucleoporin_FG, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82215, SSF82215, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51434, NUP_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

I2GXE4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFGQNRPAFG NNQGFGGSSS SPFGMQQNQQ QQNSSFGNAN SNTTSQSPFG
60 70 80 90 100
GFGSGGASTS GTSSMFGNSN NANRPFSATG TNNNVGGSLF GGGLTGGANI
110 120 130 140 150
TATSTSSNPM GGLSGAGSGT AIKPYTAFQD KDATTGSINV YQSISCMPEY
160 170 180 190 200
RNFSPEELRF QDYQANRKFA TSNTNQFGTT SNSIGTSGFG NTSGGLFGQQ
210 220 230 240 250
NNMTSGTGFG SNSSNTGTNQ FGNNAGGFLN NSSNTTNSFA SSNNNTFGMN
260 270 280 290 300
NSAGSSLFGN NQNNSTNGGL FGQNNTTTNN NNMGRFGQQN NAFGTNNASN
310 320 330 340 350
AGTGLFGQNN GQKGNGLFGQ NNNNSFGNNA QQAGGFFGQS ANNQQAGGIF
360 370 380 390 400
GQSNMQTSNN SNAAGGLFGN KQGTSLFGQA TSTQQSGGLF GQSNTNSNQQ
410 420 430 440 450
SNNLFGQSNN NQSGGLFGQN SGSQQQSGSL FGQPNNQQSG GLFGQSNNNQ
460 470 480 490 500
QQGRSLFGQT NSNFSGFGQQ TQTQASGGLF GNKSTSGSLF SQSNQNNGFG
510 520 530 540 550
SNMNSNTGGI FGQNNNQQQQ GGGLFGQNNN QSQQGGGLFG QNNSQQQPGG
560 570 580 590 600
LFGQNNSQQS NSLFGNKPGG SAGGLFGNNN NSSGQPGSLF GNNNSQQQNG
610 620 630 640 650
GLFGSRPATQ SNGLFGNNSN QNSLTNNTGG LFGNKTSNSA GLLGNNTAAS
660 670 680 690 700
NAGGLFGNSA ANSTTSGGLF GSSQNTQAGS LFDAKQNPQS GGLFGNNSNT
710 720 730 740 750
SSTAGGLFGA KPTIGNNSSL PFGNSSTIAT SGNSLFSTNN ANQLNSSTLS
760 770 780 790 800
LIGSQQHTSV SDPYGTNELF SRITVPSSLV PKPNPMITKI ESLAKNNKLT
810 820 830 840 850
SAYKLNPTPL FSNLKSKSRT VSSTLTLGSS TNNTHQPKSL PDTNATVTSG
860 870 880 890 900
SLLLGDVKNN SNDAILSVSN MFGNNKMQDF KTLLINRREK AQALENRISS
910 920 930 940 950
TDEDPSTRLT FKVSSKKECK DSDQEKSSTE SSIFDQPQFT PTISSSKNKI
960 970 980 990 1000
IDDEKKAHYE EMDKSKSRTS SNDFTQTNIM KKASIDDEDD ITWLDNGYSI
1010 1020 1030 1040 1050
SPSLETLSSM SILQLRKVSG LTVSHPPYGK IEFQAPVDLS TVPIIPLCGD
1060 1070 1080 1090 1100
IISLTNDSFL IENEEGDGNA LNGMNVAAKI TRYNCFPIRK ENKEYIKDPS
1110 1120 1130 1140
HPLMQRHIER LKSMPGVTFE SFDPTTGMYV FSSPNIVSVF L
Length:1,141
Mass (Da):119,008
Last modified:July 11, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA4487870A3652A00
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
HE806316 Genomic DNA Translation: CCH58796.1

NCBI Reference Sequences

More...
RefSeqi
XP_004178315.1, XM_004178267.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
CCH58796; CCH58796; TBLA_0A10170

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
14493579

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tbl:TBLA_0A10170

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE806316 Genomic DNA Translation: CCH58796.1
RefSeqiXP_004178315.1, XM_004178267.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi1071379.XP_004178315.1

Genome annotation databases

EnsemblFungiiCCH58796; CCH58796; TBLA_0A10170
GeneIDi14493579
KEGGitbl:TBLA_0A10170

Phylogenomic databases

eggNOGiKOG0845, Eukaryota
HOGENOMiCLU_011051_0_0_1
InParanoidiI2GXE4
OrthoDBi1060706at2759

Family and domain databases

Gene3Di3.30.1610.10, 1 hit
InterProiView protein in InterPro
IPR025574, Nucleoporin_FG_rpt
IPR037665, Nucleoporin_S59-like
IPR037637, NUP98-NUP96
IPR007230, Peptidase_S59
IPR036903, Peptidase_S59_sf
PANTHERiPTHR23198, PTHR23198, 2 hits
PTHR23198:SF17, PTHR23198:SF17, 2 hits
PfamiView protein in Pfam
PF04096, Nucleoporin2, 1 hit
PF13634, Nucleoporin_FG, 7 hits
SUPFAMiSSF82215, SSF82215, 1 hit
PROSITEiView protein in PROSITE
PS51434, NUP_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI2GXE4_TETBL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: I2GXE4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: February 10, 2021
This is version 41 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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