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Protein

NADPH:adrenodoxin oxidoreductase, mitochondrial

Gene

FDXR

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 reduced adrenodoxin + NADP+ = 2 oxidized adrenodoxin + NADPH.UniRule annotation

Cofactori

FADUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei49FAD; via amide nitrogenUniRule annotation1
Binding sitei69FADUniRule annotation1
Binding sitei77FAD; via amide nitrogenUniRule annotation1
Binding sitei113FAD; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei246NADPUniRule annotation1
Binding sitei404FAD; via amide nitrogenUniRule annotation1
Binding sitei411NADP; via amide nitrogenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi184 – 187NADPUniRule annotation4
Nucleotide bindingi234 – 235NADPUniRule annotation2
Nucleotide bindingi411 – 413FADUniRule annotation3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandFADUniRule annotation, Flavoprotein, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH:adrenodoxin oxidoreductase, mitochondrialUniRule annotation (EC:1.18.1.6UniRule annotation)
Gene namesi
Name:FDXRImported
OrganismiMacaca mulatta (Rhesus macaque)Imported
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MitochondrionUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliI2CWN6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 195Pyr_redox_2InterPro annotationAdd BLAST156

Sequence similaritiesi

Belongs to the ferredoxin--NADP reductase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1800 Eukaryota
COG0493 LUCA

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR021163 Ferredox_Rdtase_adrenod
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PIRSFiPIRSF000362 FNR, 1 hit

Sequencei

Sequence statusi: Complete.

I2CWN6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASRCWRWWG WSAWPRTRPP PAGSTPSFRH HLSTQEKTPQ ICVVGSGPAG
60 70 80 90 100
FYTAQHLLKH PQAHVDIYEK QPVPFGLVRF GVAPDHPEVK NVINTFTQTA
110 120 130 140 150
HSGRCAFWGN VEVGRDVTVP ELREAYHAVV LSYGAEDHRA LEIPGEELPG
160 170 180 190 200
VCSARAFVGW YNGLPENREL EPDLSCDTAV ILGQGNVALD VARILLTPPE
210 220 230 240 250
HLEALLLCQR TDITKAALGV LRQSRVKTVW LVGRRGPLQV AFTIKELREM
260 270 280 290 300
IQLPGARPIL DPADFLGLQD KIKEVPRPRK RLTELLLRTA TEKPGPEEAA
310 320 330 340 350
RWASASRAWG LRFFRSPQQV LPSPDGRRAA GVRLAVTRLE GVGEATRAVP
360 370 380 390 400
TGDMEDLPCG LVLSSVGYKS RPVDPSVPFD SKLGVIPNVE GRVMDVPGLY
410 420 430 440 450
CSGWVKRGPT GVIATTMTDS FLTGQMLLQD LKAGLLPSGP RPGYAAIQAL
460 470 480 490
LSSRGVRPVS FSDWEKLDAE EVARGQGTGK PREKLVDPQE MLRLLGH
Length:497
Mass (Da):54,526
Last modified:July 11, 2012 - v1
Checksum:i078C0612E97EAED0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JV636031 mRNA Translation: AFJ71371.1
RefSeqiXP_014975768.1, XM_015120282.1
UniGeneiMmu.21094

Genome annotation databases

GeneIDi699336

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JV636031 mRNA Translation: AFJ71371.1
RefSeqiXP_014975768.1, XM_015120282.1
UniGeneiMmu.21094

3D structure databases

ProteinModelPortaliI2CWN6
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi699336

Organism-specific databases

CTDi2232

Phylogenomic databases

eggNOGiKOG1800 Eukaryota
COG0493 LUCA

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR021163 Ferredox_Rdtase_adrenod
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PIRSFiPIRSF000362 FNR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiI2CWN6_MACMU
AccessioniPrimary (citable) accession number: I2CWN6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: November 7, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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