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Protein

Alanine racemase

Gene

alr

Organism
Phycisphaera mikurensis (strain NBRC 102666 / KCTC 22515 / FYK2301M01)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei39Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei140SubstrateUniRule annotation1
Active sitei271Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei319Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:PSMK_09540Imported
OrganismiPhycisphaera mikurensis (strain NBRC 102666 / KCTC 22515 / FYK2301M01)Imported
Taxonomic identifieri1142394 [NCBI]
Taxonomic lineageiBacteriaPlanctomycetesPhycisphaeraePhycisphaeralesPhycisphaeraceaePhycisphaera
Proteomesi
  • UP000007881 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei39N6-(pyridoxal phosphate)lysineUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliI0ICX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini250 – 378Ala_racemase_CInterPro annotationAdd BLAST129

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775
OMAiWEILCGF
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit

Sequencei

Sequence statusi: Complete.

I0ICX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPPTSNSW LEVDLAAVEA NARVLAAAAP AASLCGVVKK DAYGLGGPAV
60 70 80 90 100
GRALEAAGAG MLAVYEPREA LAIAEAGVGL PFLVLHGTLA AGDPWAALAE
110 120 130 140 150
AGRLEFQAGD GELLDALDAE GRRRGIRLPV HVHADTGMSR EGMPGPAAVD
160 170 180 190 200
AVRGIPARAG LRLAGVMTHL ATADSDARRA AGQVAAFDRL LAQMELPEHA
210 220 230 240 250
VVHLCNSYAA MREPAWHRRM IRPGIGLYGY AEPTLDRGER WETDARLRPV
260 270 280 290 300
ARWVSRIARV LDASAGAPVG YGATESLEKD TRLGLVPVGY ADGYPLALSG
310 320 330 340 350
RGVVRVGGAE CRVVGRVSMD QVMVDLSAAP GAGPGAEVEV YGNDPAAPNA
360 370 380 390
LPRMAAAAGS HAYELLTRIH PRVERRHAVA RPGFGDPPDA G
Length:391
Mass (Da):40,577
Last modified:June 13, 2012 - v1
Checksum:i894F03151D73BD77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012338 Genomic DNA Translation: BAM03113.1

Genome annotation databases

EnsemblBacteriaiBAM03113; BAM03113; PSMK_09540
KEGGiphm:PSMK_09540
PATRICifig|1142394.8.peg.986

Entry informationi

Entry nameiI0ICX5_PHYMF
AccessioniPrimary (citable) accession number: I0ICX5
Entry historyiIntegrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: February 28, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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