UniProtKB - I0FVV7 (I0FVV7_MACMU)
Protein
Histone H2B
Gene
HIST1H2BK
Organism
Macaca mulatta (Rhesus macaque)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: GO_Central
- protein heterodimerization activity Source: InterPro
GO - Biological processi
- antibacterial humoral response Source: Ensembl
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: Ensembl
- defense response to Gram-negative bacterium Source: Ensembl
- defense response to Gram-positive bacterium Source: Ensembl
- innate immune response in mucosa Source: Ensembl
- killing of cells of other organism Source: Ensembl
- nucleosome assembly Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Histone H2BUniRule annotation |
Gene namesi | Name:HIST1H2BKImported |
Organismi | Macaca mulatta (Rhesus macaque)Imported |
Taxonomic identifieri | 9544 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca |
Proteomesi |
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Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Cytosol
- cytosol Source: Ensembl
Extracellular region or secreted
- extracellular space Source: Ensembl
Nucleus
- nucleoplasm Source: Ensembl
Other locations
- nucleosome Source: UniProtKB-KW
Keywords - Cellular componenti
Chromosome, Nucleosome coreUniRule annotation, NucleusUniRule annotationInteractioni
Subunit structurei
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
UniRule annotationGO - Molecular functioni
- protein heterodimerization activity Source: InterPro
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 10 – 101 | HistoneInterPro annotationAdd BLAST | 92 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 36 | DisorderedSequence analysisAdd BLAST | 36 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 17 – 35 | BasicSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT01010000222347 |
OrthoDBi | 1536672at2759 |
Family and domain databases
Gene3Di | 1.10.20.10, 1 hit |
InterProi | View protein in InterPro IPR009072, Histone-fold IPR007125, Histone_H2A/H2B/H3 IPR000558, Histone_H2B |
PANTHERi | PTHR23428, PTHR23428, 1 hit |
Pfami | View protein in Pfam PF00125, Histone, 1 hit |
PRINTSi | PR00621, HISTONEH2B |
SMARTi | View protein in SMART SM00427, H2B, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit |
PROSITEi | View protein in PROSITE PS00357, HISTONE_H2B, 1 hit |
i Sequence
Sequence statusi: Complete.
I0FVV7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPEPAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSV YVYKVLKQVH
60 70 80 90 100
PDTGISSKAM GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR
110 120
LLLPGELAKH AVSEGTKAVT KYTSAK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JV048512 mRNA Translation: AFI38583.1 |
RefSeqi | NP_001247459.1, NM_001260530.1 |
Genome annotation databases
Ensembli | ENSMMUT00000085005; ENSMMUP00000080006; ENSMMUG00000058189 |
GeneIDi | 701464 |
KEGGi | mcc:701464 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JV048512 mRNA Translation: AFI38583.1 |
RefSeqi | NP_001247459.1, NM_001260530.1 |
3D structure databases
SMRi | I0FVV7 |
ModBasei | Search... |
Genome annotation databases
Ensembli | ENSMMUT00000085005; ENSMMUP00000080006; ENSMMUG00000058189 |
GeneIDi | 701464 |
KEGGi | mcc:701464 |
Organism-specific databases
CTDi | 701464 |
Phylogenomic databases
GeneTreei | ENSGT01010000222347 |
OrthoDBi | 1536672at2759 |
Family and domain databases
Gene3Di | 1.10.20.10, 1 hit |
InterProi | View protein in InterPro IPR009072, Histone-fold IPR007125, Histone_H2A/H2B/H3 IPR000558, Histone_H2B |
PANTHERi | PTHR23428, PTHR23428, 1 hit |
Pfami | View protein in Pfam PF00125, Histone, 1 hit |
PRINTSi | PR00621, HISTONEH2B |
SMARTi | View protein in SMART SM00427, H2B, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit |
PROSITEi | View protein in PROSITE PS00357, HISTONE_H2B, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | I0FVV7_MACMU | |
Accessioni | I0FVV7Primary (citable) accession number: I0FVV7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 13, 2012 |
Last sequence update: | June 13, 2012 | |
Last modified: | December 2, 2020 | |
This is version 59 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |