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UniProtKB - I0E2I4 (I0E2I4_DROME)
Protein
Phosphatidate phosphatase
Gene
Lpin
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Catalytic activityi
Cofactori
Mg2+ARBA annotation
GO - Molecular functioni
- phosphatidate phosphatase activity Source: FlyBase
- transcription coactivator activity Source: FlyBase
GO - Biological processi
- cellular lipid metabolic process Source: GO_Central
- cellular response to insulin stimulus Source: GO_Central
- fatty acid catabolic process Source: GO_Central
- imaginal disc-derived wing vein specification Source: FlyBase
- lipid homeostasis Source: FlyBase
- negative regulation of BMP signaling pathway Source: FlyBase
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of cellular ketone metabolic process Source: FlyBase
- regulation of fatty acid metabolic process Source: FlyBase
- regulation of transcription by RNA polymerase II Source: FlyBase
- response to starvation Source: FlyBase
- triglyceride biosynthetic process Source: FlyBase
Keywordsi
Molecular function | HydrolaseImportedARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:LpinImported Synonyms:anon-WO0118547.133Imported, CG8709-RHImported, dLipinImported, DLpinImported, Dmel\CG8709Imported, DmLpinImported, EP2431Imported, LIPINImported ORF Names:CG8709Imported, Dmel_CG8709Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0263593, Lpin |
VEuPathDBi | VectorBase:FBgn0263593 |
Subcellular locationi
Extracellular region or secreted
- female germline ring canal inner rim Source: FlyBase
Nucleus
- nucleus Source: FlyBase
Other locations
- cytoplasm Source: FlyBase
Expressioni
Gene expression databases
Bgeei | FBgn0263593, Expressed in capitellum (Drosophila) and 56 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 762 – 917 | LNS2InterPro annotationAdd BLAST | 156 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 163 – 326 | DisorderedSequence analysisAdd BLAST | 164 | |
Regioni | 338 – 369 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 462 – 504 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 635 – 679 | DisorderedSequence analysisAdd BLAST | 45 | |
Regioni | 968 – 997 | DisorderedSequence analysisAdd BLAST | 30 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 191 – 208 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 227 – 241 | Basic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 242 – 256 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 277 – 300 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 474 – 493 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 657 – 679 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 979 – 995 | Acidic residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the lipin family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00940000168260 |
OMAi | EYSWEWG |
Family and domain databases
InterProi | View protein in InterPro IPR036412, HAD-like_sf IPR026058, LIPIN IPR031703, Lipin_mid IPR007651, Lipin_N IPR013209, LNS2 IPR031315, LNS2/PITP |
PANTHERi | PTHR12181, PTHR12181, 1 hit |
Pfami | View protein in Pfam PF16876, Lipin_mid, 1 hit PF04571, Lipin_N, 1 hit PF08235, LNS2, 1 hit |
SMARTi | View protein in SMART SM00775, LNS2, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
I0E2I4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNSLARVFSN FRDFYNDINA ATLTGAIDVI VVEQRDGEFQ CSPFHVRFGK
60 70 80 90 100
LGVLRSREKV VDIEINGVPV DIQMKLGDSG EAFFVEECLE DEDEELPANL
110 120 130 140 150
ATSPIPNSFL ASRDKANDTM EDISGVVTDK HTDNTLERRN LSEKLKEFTT
160 170 180 190 200
QKIRQEWAEH EELFQGEKKP ADSDSLDNQS KASNEAETEK AIPAVIEDTE
210 220 230 240 250
KEKDQIKPDV NLTTVTTSEA TKEVSKSKTK KRRKKSQMKK NAQRKNSSSS
260 270 280 290 300
SLGSAGGGDL PSAETPSLGV SNIDEGDAPI SSATNNNNTS SSNDEQLSAP
310 320 330 340 350
LVTARTGDDS PLSEIPHTPT SNPRLDLDIH FFSDTEITTP VGGGGAGSGR
360 370 380 390 400
AAGGRPSTPI QSDSELETTM RDNRHVVTEE STASWKWGEL PTPEQAKNEA
410 420 430 440 450
MSAAQVQQSE HQSMLSNMFS FMKRANRLRK EKGVGEVGDI YLSDLDAGSM
460 470 480 490 500
DPEMAALYFP SPLSKAASPP EEDGESGNGT SLPHSPSSLE EGQKSIDSDF
510 520 530 540 550
DETKQQRDNN RYLDFVAMSM CGMSEQGAPP SDEEFDRHLV NYPDVCKSPS
560 570 580 590 600
IFSSPNLVVR LNGKYYTWMA ACPIVMTMIT FQKPLTHDAI EQLMSQTVDG
610 620 630 640 650
KCLPGDEKQE AVAQADNGGQ TKRYWWSWRR SQDAAPNHLN NTHGMPLGKD
660 670 680 690 700
EKDGDQAAVA TQTSRPTSPD ITDPTLSKSD SLVNAENTSA LVDNLEELTM
710 720 730 740 750
ASNKSDEPKE RYKKSLRLSS AAIKKLNLKE GMNEIEFSVT TAYQGTTRCK
760 770 780 790 800
CYLFRWKHND KVVISDIDGT ITKSDVLGHI LPMVGKDWAQ LGVAQLFSKI
810 820 830 840 850
EQNGYKLLYL SARAIGQSRV TREYLRSIRQ GNVMLPDGPL LLNPTSLISA
860 870 880 890 900
FHREVIEKKP EQFKIACLSD IRDLFPDKEP FYAGYGNRIN DVWAYRAVGI
910 920 930 940 950
PIMRIFTINT KGELKHELTQ TFQSSGYINQ SLEVDEYFPL LTNQDEFDYR
960 970 980 990 1000
TDIFDDEESE EELQFSDDYD VDVEHGSSEE SSGDEDDDEA LYNDDFANDD
1010 1020 1030 1040
NGIQAVVASG DERTADVGLI MRVRRVSTKN EVIMASPPKW INS
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8SXP0 | Q8SXP0_DROME | Phosphatidate phosphatase | Lpin anon-WO0118547.133, dLipin, DLpin, Dmel\CG8709, DmLpin | 1,089 | Annotation score: | ||
A8DY69 | A8DY69_DROME | Phosphatidate phosphatase | Lpin anon-WO0118547.133, dLipin, DLpin, Dmel\CG8709, DmLpin | 1,035 | Annotation score: | ||
A0A0B4JCQ5 | A0A0B4JCQ5_DROME | Phosphatidate phosphatase | Lpin anon-WO0118547.133, dLipin, DLpin, Dmel\CG8709, DmLpin | 1,088 | Annotation score: | ||
A0A0B4JD00 | A0A0B4JD00_DROME | Phosphatidate phosphatase | Lpin anon-WO0118547.133, dLipin, DLpin, Dmel\CG8709, DmLpin | 1,034 | Annotation score: | ||
A0A0B4JD27 | A0A0B4JD27_DROME | Lipin, isoform E | Lpin anon-WO0118547.133, dLipin, DLpin, Dmel\CG8709, DmLpin | 1,045 | Annotation score: | ||
A0A0B4JD31 | A0A0B4JD31_DROME | Lipin, isoform L | Lpin anon-WO0118547.133, dLipin, DLpin, Dmel\CG8709, DmLpin | 992 | Annotation score: | ||
A0A0B4JCS1 | A0A0B4JCS1_DROME | Lipin, isoform G | Lpin anon-WO0118547.133, dLipin, DLpin, Dmel\CG8709, DmLpin | 1,016 | Annotation score: | ||
E5DK16 | E5DK16_DROME | Lipin isoform J | Lpin anon-WO0118547.133, dLipin, DLpin, Dmel\CG8709, DmLpin | 962 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: ADV37128.1 BT133462 mRNA Translation: AFH97152.1 |
RefSeqi | NP_001188879.1, NM_001201950.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0303578; FBpp0292611; FBgn0263593 |
GeneIDi | 35790 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: ADV37128.1 BT133462 mRNA Translation: AFH97152.1 |
RefSeqi | NP_001188879.1, NM_001201950.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
DNASUi | 35790 |
Genome annotation databases
EnsemblMetazoai | FBtr0303578; FBpp0292611; FBgn0263593 |
GeneIDi | 35790 |
Organism-specific databases
CTDi | 35790 |
FlyBasei | FBgn0263593, Lpin |
VEuPathDBi | VectorBase:FBgn0263593 |
Phylogenomic databases
GeneTreei | ENSGT00940000168260 |
OMAi | EYSWEWG |
Miscellaneous databases
BioGRID-ORCSi | 35790, 0 hits in 3 CRISPR screens |
GenomeRNAii | 35790 |
Gene expression databases
Bgeei | FBgn0263593, Expressed in capitellum (Drosophila) and 56 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR036412, HAD-like_sf IPR026058, LIPIN IPR031703, Lipin_mid IPR007651, Lipin_N IPR013209, LNS2 IPR031315, LNS2/PITP |
PANTHERi | PTHR12181, PTHR12181, 1 hit |
Pfami | View protein in Pfam PF16876, Lipin_mid, 1 hit PF04571, Lipin_N, 1 hit PF08235, LNS2, 1 hit |
SMARTi | View protein in SMART SM00775, LNS2, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | I0E2I4_DROME | |
Accessioni | I0E2I4Primary (citable) accession number: I0E2I4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 13, 2012 |
Last sequence update: | June 13, 2012 | |
Last modified: | January 19, 2022 | |
This is version 67 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |