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Protein

Proteasome subunit alpha type

Gene

Prosalpha6

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine proteasePROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha typeUniRule annotation (EC:3.4.25.1UniRule annotation)
Gene namesi
Name:Prosalpha6Imported
Synonyms:143314_atImported, Alpha-6Imported, alpha-6Imported, alpha6Imported, alpha_dmImported, anon-SAGE:Wang-116Imported, Dmel\CG4904Imported, pros 35Imported, PROS-35Imported, Pros-35Imported, PROS-Dm35Imported, Pros-Dm35Imported, Pros35Imported, pros35Imported, Pros35-RAImported, PSMA1Imported
ORF Names:CG4904Imported, Dmel_CG4904Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0250843 Prosalpha6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmPROSITE-ProRule annotation, NucleusUniRule annotationSAAS annotation, ProteasomePROSITE-ProRule annotationImported

Expressioni

Gene expression databases

BgeeiFBgn0250843 Expressed in 46 organ(s), highest expression level in embryo

Interactioni

Subunit structurei

The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 28PROTEASOME_ALPHA_1InterPro annotationAdd BLAST23

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0863 Eukaryota
COG0638 LUCA
KOiK02725
OMAiCPSANYY
OrthoDBiEOG091G0DNK

Family and domain databases

CDDicd03749 proteasome_alpha_type_1, 1 hit
Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR023332 Proteasome_alpha-type
IPR035144 Proteasome_alpha1
IPR000426 Proteasome_asu_N
IPR001353 Proteasome_sua/b
PANTHERiPTHR11599:SF12 PTHR11599:SF12, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PF10584 Proteasome_A_N, 1 hit
SMARTiView protein in SMART
SM00948 Proteasome_A_N, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00388 PROTEASOME_ALPHA_1, 1 hit
PS51475 PROTEASOME_ALPHA_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

I0DHK3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFRNQYDSDV TVWSPQGRLH QVEYAMEAVK LGTATVGLKN KDYAVLVALC
60 70 80 90 100
KPTSELSDTQ RKIIPIDDHL GISIAGLTAD ARVLSRYLRS ECLNYKHSYD
110 120 130 140 150
TTYPVSRLIT NLGNKMQTTT QRYDRRPYGV GLLVAGYDER GPHIYQVTPS
160 170 180 190 200
ATFFNCKANS IGSRSQSART YLEKNLNKFL DSSKDEIIRH GIRAILGTLP
210 220 230 240 250
TDEQGKDAGQ YDITVAIVGK DQPFTILSNK DSAKHVAIAK ENDNDTPRND
260 270
DDDDRPSPPE EPAAGPRDPE VLVATEQRP
Length:279
Mass (Da):31,059
Last modified:June 13, 2012 - v1
Checksum:i1478BDC2C61EF3F1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P12881PSA1_DROME
Proteasome subunit alpha type-1
Prosalpha6 PROS-35, Pros35, CG4904
279Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT133448 mRNA Translation: AFH89821.1
AE014134 Genomic DNA Translation: AHN54312.1
RefSeqiNP_001285798.1, NM_001298869.1
NP_523532.1, NM_078808.4
UniGeneiDm.2599

Genome annotation databases

EnsemblMetazoaiFBtr0079948; FBpp0079538; FBgn0250843
FBtr0343606; FBpp0310201; FBgn0250843
GeneIDi34359
KEGGidme:Dmel_CG4904

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT133448 mRNA Translation: AFH89821.1
AE014134 Genomic DNA Translation: AHN54312.1
RefSeqiNP_001285798.1, NM_001298869.1
NP_523532.1, NM_078808.4
UniGeneiDm.2599

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0079948; FBpp0079538; FBgn0250843
FBtr0343606; FBpp0310201; FBgn0250843
GeneIDi34359
KEGGidme:Dmel_CG4904

Organism-specific databases

CTDi34359
FlyBaseiFBgn0250843 Prosalpha6

Phylogenomic databases

eggNOGiKOG0863 Eukaryota
COG0638 LUCA
KOiK02725
OMAiCPSANYY
OrthoDBiEOG091G0DNK

Miscellaneous databases

ChiTaRSinAChRalpha6 fly
GenomeRNAii34359

Gene expression databases

BgeeiFBgn0250843 Expressed in 46 organ(s), highest expression level in embryo

Family and domain databases

CDDicd03749 proteasome_alpha_type_1, 1 hit
Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR023332 Proteasome_alpha-type
IPR035144 Proteasome_alpha1
IPR000426 Proteasome_asu_N
IPR001353 Proteasome_sua/b
PANTHERiPTHR11599:SF12 PTHR11599:SF12, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PF10584 Proteasome_A_N, 1 hit
SMARTiView protein in SMART
SM00948 Proteasome_A_N, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00388 PROTEASOME_ALPHA_1, 1 hit
PS51475 PROTEASOME_ALPHA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiI0DHK3_DROME
AccessioniPrimary (citable) accession number: I0DHK3
Entry historyiIntegrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: November 7, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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