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Entry version 47 (12 Aug 2020)
Sequence version 1 (13 Jun 2012)
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Protein
Submitted name:

ATP-binding cassette transporter subfamily B member 4a

Gene

ABCB4a

Organism
Strongylocentrotus purpuratus (Purple sea urchin)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi451 – 458ATPPROSITE-ProRule annotation8
Nucleotide bindingi1089 – 1096ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotationImportedARBA annotation, Nucleotide-binding

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.201.16, the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ATP-binding cassette transporter subfamily B member 4aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABCB4aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStrongylocentrotus purpuratus (Purple sea urchin)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7668 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaStrongylocentrotidaeStrongylocentrotus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
Transmembranei214 – 233HelicalSequence analysisAdd BLAST20
Transmembranei239 – 260HelicalSequence analysisAdd BLAST22
Transmembranei316 – 340HelicalSequence analysisAdd BLAST25
Transmembranei355 – 373HelicalSequence analysisAdd BLAST19
Transmembranei729 – 753HelicalSequence analysisAdd BLAST25
Transmembranei773 – 796HelicalSequence analysisAdd BLAST24
Transmembranei852 – 872HelicalSequence analysisAdd BLAST21
Transmembranei956 – 976HelicalSequence analysisAdd BLAST21
Transmembranei996 – 1014HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini76 – 381ABC transmembrane type-1InterPro annotationAdd BLAST306
Domaini416 – 652ABC transporterInterPro annotationAdd BLAST237
Domaini733 – 1019ABC transmembrane type-1InterPro annotationAdd BLAST287
Domaini1054 – 1291ABC transporterInterPro annotationAdd BLAST238

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni22 – 56DisorderedSequence analysisAdd BLAST35
Regioni657 – 706DisorderedSequence analysisAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi36 – 56PolyampholyteSequence analysisAdd BLAST21
Compositional biasi665 – 679PolyampholyteSequence analysisAdd BLAST15
Compositional biasi680 – 697PolarSequence analysisAdd BLAST18

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000604_17_2_1

KEGG Orthology (KO)

More...
KOi
K05659

Database of Orthologous Groups

More...
OrthoDBi
186078at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR030275, MDR3
IPR027417, P-loop_NTPase
IPR039421, Type_I_exporter

The PANTHER Classification System

More...
PANTHERi
PTHR24221, PTHR24221, 1 hit
PTHR24221:SF241, PTHR24221:SF241, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664, ABC_membrane, 2 hits
PF00005, ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits
SSF90123, SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929, ABC_TM1F, 2 hits
PS00211, ABC_TRANSPORTER_1, 2 hits
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

I0DHH7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVVENGHTKG LDDDGTEVAF KNGNYGATNG KDTANGTIKG EEKSDEKENE
60 70 80 90 100
KEEEKPQVPF TRLFRYATGL DGLFMFIGCF AAVCHGCAWP ALNIVFGGLI
110 120 130 140 150
DEFVDFDKLN TTNTTDFTAT LPPGLDPAKE FDNQMQMYAV IFTYIGIGVM
160 170 180 190 200
VMAYLQSSMW TLAGERQIYK IRQAFFNAIL HQEIQWFDVH KSGELTSRLA
210 220 230 240 250
DDMERVKDGL GDKIALCLQS LSLFLAGFGI AFWKSWELTL VLLSTTPLLA
260 270 280 290 300
AAGGFMAYFL TSFAKLEQES YAQAGSVAEE VLSCVRTVIA FGGEQKEVTR
310 320 330 340 350
YEKELKEARD VGVKKGVTSG VGMGITMFIM FGSYALAFWY GPKLVADGRI
360 370 380 390 400
TGGDVMIVFF SVMIGSFSIG NISPSMTAIT AARGAAVTLF DVIDARPAID
410 420 430 440 450
TRSKKGIVPA EMTGNIDFQG VEFSYPTRDD VPVLKGVDLS IRKGQTVALV
460 470 480 490 500
GSSGCGKSTT INLLLRFYEK LGGNILIDGH KIEELNLHWL RRHMGVVSQE
510 520 530 540 550
PVLFNCSIET NISYGRDGVT KEEIINAAKM ANAHDFISKL PKGYDTMVGE
560 570 580 590 600
RGAQLSGGQK QRVAIARALV RNPPILLLDE ATSALDRESE KVVQQALDKA
610 620 630 640 650
SEGRTTLVIA HRLTTIRNAD VIYAFEDGRV VEFGDHAELM KRDGVYKQLV
660 670 680 690 700
TLQTLDGAGE ESTSSSKEVV RKESIKRLPS RQMSRQISRQ MSNGSGKMEE
710 720 730 740 750
SVEVKEEVEE EEVEERGYLE ILKMNKPEWL YIVVGCVFAG ILGVAMPAFA
760 770 780 790 800
ILFSEVIAIF SLPADELREE SVFWALMFLA LGGAFFVSNS VTGYCFSISG
810 820 830 840 850
EELTLRLRKK AFWTILRQDC AYFDQPSHST GALATRLSSD ASNVKGATGM
860 870 880 890 900
RISTIVQAIV TMVVAITIGF VFGWKLALLI FGCLPVLALS GALEMKILQG
910 920 930 940 950
GHEKDAALIE EAGKIAAEAI ENVRTVASLN LEDRMIANYT EQLQNPYRQG
960 970 980 990 1000
KINSQINGLA FAVSQAMIFF IYAASFRLGG YLVSIGDMTV DEVFKVVFGV
1010 1020 1030 1040 1050
AFAGISVGQS LAFLPDYAKA RHSADLMLHL FSIKPLIDNY STDGAQPQKV
1060 1070 1080 1090 1100
DGKIEYSGLK FSYPTRPDVT VLKGLSLTIK PGQTVALVGE SGCGKSTLVS
1110 1120 1130 1140 1150
LLERFYDPAQ GSVALDGTPV KDINIQWLRA NMAIVSQEPI LFACSIGDNI
1160 1170 1180 1190 1200
QYGVETPMEQ AAIENVAKMA NIHDFIASLP LGYDTLVGEK GAQLSGGQKQ
1210 1220 1230 1240 1250
RVAIARAMAR NPRILLLDEA TSALDTESEK VVQAALDNAM QGRTSIVIAH
1260 1270 1280 1290
RLSTIQNADT IAVIREGVVV ESGSHQELLQ SKGHYFTLTG GKIDVESE
Length:1,298
Mass (Da):141,531
Last modified:June 13, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE54F04BAFE5819FD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JQ354983 mRNA Translation: AFH89631.1

NCBI Reference Sequences

More...
RefSeqi
NP_001268680.1, NM_001281751.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
756756

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spu:756756

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ354983 mRNA Translation: AFH89631.1
RefSeqiNP_001268680.1, NM_001281751.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

TCDBi3.A.1.201.16, the atp-binding cassette (abc) superfamily

Genome annotation databases

GeneIDi756756
KEGGispu:756756

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5244

Phylogenomic databases

HOGENOMiCLU_000604_17_2_1
KOiK05659
OrthoDBi186078at2759

Family and domain databases

InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR030275, MDR3
IPR027417, P-loop_NTPase
IPR039421, Type_I_exporter
PANTHERiPTHR24221, PTHR24221, 1 hit
PTHR24221:SF241, PTHR24221:SF241, 1 hit
PfamiView protein in Pfam
PF00664, ABC_membrane, 2 hits
PF00005, ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
SSF90123, SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929, ABC_TM1F, 2 hits
PS00211, ABC_TRANSPORTER_1, 2 hits
PS50893, ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI0DHH7_STRPU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: I0DHH7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: August 12, 2020
This is version 47 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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