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Protein

Proteasome subunit alpha

Gene

psmA

Organism
Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

Enzyme regulationi

The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine proteaseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alphaUniRule annotation (EC:3.4.25.1UniRule annotation)
Alternative name(s):
20S proteasome alpha subunitUniRule annotation
Proteasome core protein PsmAUniRule annotation
Gene namesi
Name:psmAUniRule annotation
Ordered Locus Names:FFONT_0712Imported
OrganismiFervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)Imported
Taxonomic identifieri1163730 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiFervidicoccalesFervidicoccaceaeFervidicoccus
Proteomesi
  • UP000007391 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation, ProteasomeUniRule annotationImported

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 32PROTEASOME_ALPHA_1InterPro annotationAdd BLAST23

Sequence similaritiesi

Belongs to the peptidase T1A family.UniRule annotation

Phylogenomic databases

KOiK03432
OMAiFQVEYAR
OrthoDBiPOG093Z086S

Family and domain databases

Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00289_A Proteasome_A_A, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR023332 Proteasome_alpha-type
IPR019982 Proteasome_asu_arc
IPR000426 Proteasome_asu_N
IPR001353 Proteasome_sua/b
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PF10584 Proteasome_A_N, 1 hit
SMARTiView protein in SMART
SM00948 Proteasome_A_N, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR03633 arc_protsome_A, 1 hit
PROSITEiView protein in PROSITE
PS51475 PROTEASOME_ALPHA_2, 1 hit

Sequencei

Sequence statusi: Complete.

I0A143-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFSPAMMGY DRALTVFSPD GRLYQVQYAF EAVKQGWSTV GIKTPGGVVL
60 70 80 90 100
AAEKAVTKSL MDVVSIEKVS MIDTHIGVTF AGFGGDGRVL IEYARQIAVS
110 120 130 140 150
HRLTYGEPIP IEYLTKQVSD LKQAYTQHGG VRPFGVSLLI GGIDSSGPQL
160 170 180 190 200
FKTDPAGQYF GYFATSMGRG EAQIEEKLEK NYRKDMSLEE GILLALKVLK
210 220 230
ESSDQDLKAQ NFDVGIILAE KKEFRKLTLP EIEDYLKKI
Length:239
Mass (Da):26,372
Last modified:June 13, 2012 - v1
Checksum:i378119746FC3CD81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003423 Genomic DNA Translation: AFH42700.1

Genome annotation databases

EnsemblBacteriaiAFH42700; AFH42700; FFONT_0712
KEGGiffo:FFONT_0712

Similar proteinsi

Entry informationi

Entry nameiI0A143_FERFK
AccessioniPrimary (citable) accession number: I0A143
Entry historyiIntegrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: March 28, 2018
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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