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Protein

Aspartate carbamoyltransferase

Gene

pyrB

Organism
Thermus thermophilus JL-18
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes (S)-dihydroorotate from bicarbonate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Carbamoyl-phosphate synthase small chain (carA), Carbamoyl-phosphate synthase large chain (carB)
  2. Aspartate carbamoyltransferase (pyrB)
  3. Dihydroorotase (pyrC)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-dihydroorotate from bicarbonate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationImported
Biological processPyrimidine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciTTHE798128:G1H4J-1290-MONOMER
UniPathwayiUPA00070; UER00116

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate carbamoyltransferaseUniRule annotation (EC:2.1.3.2UniRule annotation)
Alternative name(s):
Aspartate transcarbamylaseUniRule annotation
Short name:
ATCaseUniRule annotation
Gene namesi
Name:pyrBUniRule annotation
ORF Names:TtJL18_1270Imported
OrganismiThermus thermophilus JL-18Imported
Taxonomic identifieri798128 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000007388 Componenti: Chromosome

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 145OTCace_NInterPro annotationAdd BLAST144
Domaini151 – 294OTCaceInterPro annotationAdd BLAST144

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

KOiK00609
OrthoDBiPOG091H00PQ

Family and domain databases

Gene3Di3.40.50.1370, 3 hits
HAMAPiMF_00001 Asp_carb_tr, 1 hit
InterProiView protein in InterPro
IPR006132 Asp/Orn_carbamoyltranf_P-bd
IPR006130 Asp/Orn_carbamoylTrfase
IPR036901 Asp/Orn_carbamoylTrfase_sf
IPR002082 Asp_carbamoyltransf
IPR006131 Asp_carbamoyltransf_Asp/Orn-bd
PANTHERiPTHR11405:SF16 PTHR11405:SF16, 1 hit
PfamiView protein in Pfam
PF00185 OTCace, 1 hit
PF02729 OTCace_N, 1 hit
PRINTSiPR00100 AOTCASE
PR00101 ATCASE
SUPFAMiSSF53671 SSF53671, 1 hit
TIGRFAMsiTIGR00670 asp_carb_tr, 1 hit
PROSITEiView protein in PROSITE
PS00097 CARBAMOYLTRANSFERASE, 1 hit

Sequencei

Sequence statusi: Complete.

H9ZS50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHLLDFQGW TRPEVESLLD TARVMREVLE RPVKKVPALQ GFTVATVFFE
60 70 80 90 100
PSTRTRISFE LAARRMSADV VSFAAQTSSL QKGESYKDTL LTLEAMGVDA
110 120 130 140 150
YVIRADSAGV PHQATRWVKG TVINGGDGRR AHPTQALLDA YTLLEALGTL
160 170 180 190 200
EGKKVAIVGD ILHSRVARSN AELLSLLGAQ VFCAGPPSLL PQSLPGAHLT
210 220 230 240 250
PRLEEALEEA DAVMVLRLQK ERMEAGLVHL EDYVARYQVT EKRLALAKPQ
260 270 280 290 300
APLLHPGPMN RDVELEGTLA DSARSLVNRQ VQNGVAVRMA VLYHLLVGKG

R
Length:301
Mass (Da):32,955
Last modified:June 13, 2012 - v1
Checksum:i62E47D70E5A5F5C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003252 Genomic DNA Translation: AFH39160.1
RefSeqiWP_014629786.1, NC_017587.1

Genome annotation databases

EnsemblBacteriaiAFH39160; AFH39160; TtJL18_1270
KEGGittl:TtJL18_1270
PATRICifig|798128.4.peg.1240

Similar proteinsi

Entry informationi

Entry nameiH9ZS50_THETH
AccessioniPrimary (citable) accession number: H9ZS50
Entry historyiIntegrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: March 28, 2018
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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