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Entry version 75 (26 Feb 2020)
Sequence version 1 (13 Jun 2012)
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Protein
Submitted name:

Unc-13, isoform E

Gene

unc-13

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-181429 Serotonin Neurotransmitter Release Cycle
R-DME-181430 Norepinephrine Neurotransmitter Release Cycle
R-DME-210500 Glutamate Neurotransmitter Release Cycle
R-DME-212676 Dopamine Neurotransmitter Release Cycle
R-DME-264642 Acetylcholine Neurotransmitter Release Cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Unc-13, isoform EImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:unc-13Imported
Synonyms:Dmel\CG2999Imported, drunc13Imported, DUNC-13Imported, Dunc-13Imported, dUNC-13Imported, dUnc-13Imported, dunc-13Imported, Dunc13Imported, l(4)ry16Imported, Munc-13Imported, uncImported, UNC-13Imported, Unc-13Imported, UNC-13-BImported, Unc13Imported, UNC13AImported, Unc13AImported, UNC13BImported, Unc13BImported
ORF Names:CG2999Imported, Dmel_CG2999Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0025726 unc-13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
H9XVP2

PRoteomics IDEntifications database

More...
PRIDEi
H9XVP2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0025726 Expressed in head and 6 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
H9XVP2 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0300963

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
H9XVP2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2037 – 2087Phorbol-ester/DAG-typeInterPro annotationAdd BLAST51
Domaini2161 – 2253C2InterPro annotationAdd BLAST93
Domaini2575 – 2718MHD1InterPro annotationAdd BLAST144
Domaini2830 – 2996MHD2InterPro annotationAdd BLAST167
Domaini3032 – 3124C2InterPro annotationAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1539 – 1569DisorderedSequence analysisAdd BLAST31
Regioni1716 – 1828DisorderedSequence analysisAdd BLAST113
Regioni1939 – 1972DisorderedSequence analysisAdd BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili742 – 762Sequence analysisAdd BLAST21
Coiled coili1916 – 1936Sequence analysisAdd BLAST21
Coiled coili2759 – 2779Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1749 – 1781PolarSequence analysisAdd BLAST33

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, Zinc-fingerSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1011 Eukaryota
ENOG410XS5D LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168389

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000387_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H9XVP2

Database for complete collections of gene phylogenies

More...
PhylomeDBi
H9XVP2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00029 C1, 1 hit
cd04027 C2B_Munc13, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR010439 CAPS_dom
IPR014770 Munc13_1
IPR014772 Munc13_dom-2
IPR019558 Munc13_subgr_dom-2
IPR002219 PE/DAG-bd
IPR027080 Unc-13
IPR037302 Unc-13_C2B

The PANTHER Classification System

More...
PANTHERi
PTHR10480 PTHR10480, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00130 C1_1, 1 hit
PF00168 C2, 2 hits
PF06292 DUF1041, 1 hit
PF10540 Membr_traf_MHD, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00360 C2DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00109 C1, 1 hit
SM00239 C2, 2 hits
SM01145 DUF1041, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 2 hits
PS51258 MHD1, 1 hit
PS51259 MHD2, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

H9XVP2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMNTSQLQVT GDTEKKSQLL KKELKINTQE KLIFAENALK SQIKIKEQLR
60 70 80 90 100
LQQQSTIYAS SLLSSSAAGS VRAPLLSQGH LNSIQHNMDF DLAKAQIPEM
110 120 130 140 150
QPPMSKSPNG LDFSYLSYPS INTNESMISI KSEQQLCQSY NSEQHSDYII
160 170 180 190 200
SDYMDKIATR ISLLETELKF AWRALDLLST EYGKIWIRLE KLENISIEQQ
210 220 230 240 250
SVVGNLVDLI GASKKELQKV DIERMKVPLY QDEDQLLPLE MEDTLDIDIQ
260 270 280 290 300
SSNRDFDKNL TFENHEKTFV TKHTQATKSE DLMNSAYAID SHPNFENIDF
310 320 330 340 350
NGKNLDIGII KFGFEKGYEP KQKGNQSDFE AYKESRTKLY SDSDLMLYER
360 370 380 390 400
QQFLANSARA ELMKEFLNGR RVLNEISASS GALSKSSEKD KNLVKPREPL
410 420 430 440 450
LSEIDDTYVR RSTCELVSPS SNNFFQIAAS KTGEGGNQVL PIEDTGGTES
460 470 480 490 500
PANINEVDES FYKNLNEAYR DNELSSEIFK VDALLHQSEA THDHISFIRN
510 520 530 540 550
QSTSSPVLNN QRVNAITGTQ PLQTAKACLV TEPNQHLNKE PRKHRKKKHH
560 570 580 590 600
TNEMDMINKL KCILAQAQST EIIKRDIEEL GSKLSDACVK QTETENKSDN
610 620 630 640 650
HISTSYLKDD IRKMLNNVIQ TLLGEINKIK GLQSLSATQL SQLQNAVWSE
660 670 680 690 700
ERFFQKISLV DKKLTLLLLN PLTVTEELQR LCISNTNEKF VLVIKKLKKN
710 720 730 740 750
IDTLKKLVGS SLDDFKIDNS HANMTTFHSL NPSHNSNDSS FSAHLLRNNS
760 770 780 790 800
NLDEQLKILE TQEIEIHRKK KIDEIVSGLS EETYTFNPDM EYKSQHSCTN
810 820 830 840 850
STDNIIGFSK NIYNEDEYIK SLRKSLERHN SMIFLLHLQN PEKHKVLADI
860 870 880 890 900
NDAQMDSNRA SLSPPPPAPT DTVYLNDAIN QITYQQRNGK SDSGLSSMSG
910 920 930 940 950
WSANSQVSVG LQNYDPACNN ILENCSERLQ TYHSFPLAEN SNFHSFPLSH
960 970 980 990 1000
EQAQTTNQTE FVILEENLNY IYELSKNLPI CSAYENKSIF DMKYEICDSN
1010 1020 1030 1040 1050
EIGKFSTVDE MLEWDQLNEP DKQNFSGKRL NSNLMPDLLT AQIPNSISKH
1060 1070 1080 1090 1100
NKNTSVNIEY VRQKENKGMD RRSIIEPNIY NGKSEDQICR PCLTDKLVFY
1110 1120 1130 1140 1150
PSSNSITDHN SSHDFNCLSQ QDQTRIIKEF GSAHLNQDPT NYLDYTSGTY
1160 1170 1180 1190 1200
SKAPPEVLTH ETNSSHLEFN HESESLFNSP NTSSYCKQKF VPGTSPAKPS
1210 1220 1230 1240 1250
KVWKRLNTIL ADNLKLKRVS KFNRSLSLPG DVQSQGLQRQ PRGQAGSCPF
1260 1270 1280 1290 1300
IHKRSNLAGS PVQLSKRIQK LPIRFIGRAK GVPFVRRSSS PDSAVSLDSA
1310 1320 1330 1340 1350
ADKRFSSEKG LKKKTISSKM SGLMQKAKTY KRHSFVLRRG CNMSDSELEM
1360 1370 1380 1390 1400
PDFVSSGNDN SSISTREILL NQSIEVEDEQ EDFNYKNRCD SKSVLGGSIE
1410 1420 1430 1440 1450
KLNGNLTNNL FPIVGDLKKI QSPLPLAVLT EIPSYKDEYS NKSDSIKNSP
1460 1470 1480 1490 1500
IEMPKILLET ACNQELNLAH SDDDVDKNIL ANSAKDYVNA PTFSILKTVE
1510 1520 1530 1540 1550
DASEPTMTPL HTTTTTNSSL NVTSALWVTQ QCLDLPNYPG WGSREDDDNR
1560 1570 1580 1590 1600
SQHSARTLSS SRRQSTEDSI DTDDEYFYYE LRQLEEQEKQ RAHNSAIPSC
1610 1620 1630 1640 1650
ERQNDNDVLF SQIGQLLQND VNGGDGFRHS NGCNDGEDAI IFSPSESVKL
1660 1670 1680 1690 1700
RMSEVFKELK SVVSLNPSVN NDATFEGVPI VKPTYEKLET VSDLHSAWQD
1710 1720 1730 1740 1750
VNGDLQIAAS DIDSNEDLVG NKGRETPTYN KQRKLRRLKK KTRDRKINIS
1760 1770 1780 1790 1800
KNATSSSSSC HSENECNTPL GQCTQKSVAE KDTNDISNKS EASSETSGPD
1810 1820 1830 1840 1850
TPAELSDVDI SETENGLRAD DGQNIDNMRG NSGSLLKVNR KYLLQFDVDH
1860 1870 1880 1890 1900
SLINQPLETS QYNTHMLENI TSASIPSQNR QIDSKTLMSQ SSHADGSQAV
1910 1920 1930 1940 1950
GNETAVGLSS SKWKLLKTLK ERKIEEKNNQ DKIKEDEMIK DRDKNGGGPG
1960 1970 1980 1990 2000
EVGLRTNGHP GDNPFYSNID SMPDIRPRRK SIPLVSELVL KTMAATKRNA
2010 2020 2030 2040 2050
GLTSAVPRAT LNDEDLKMHV YKKALQALIY PISSTTPHNF LLWTATSPTY
2060 2070 2080 2090 2100
CYECEGLLWG IARQGVRCTE CGVKCHEKCK DLLNADCLQR AAEKSSKHGA
2110 2120 2130 2140 2150
EDKANSIITA MKDRMKQRER EKPEIFELIR AVFSVEEKSH AGHMKAVKQS
2160 2170 2180 2190 2200
VLDGTSKWSA KIAITVICAQ GLIAKDKSGT SDPYVTVQVS KVKKRTRTMP
2210 2220 2230 2240 2250
QELNPVWNEK FHFECHNSSD RIKVRVWDED NDLKSKLRQK LTRESDDFLG
2260 2270 2280 2290 2300
QTIIEVRTLS GEMDVWYNLE KRTDKSAVSG AIRLHISVEI KGEEKVAPYH
2310 2320 2330 2340 2350
VQYTCLHENL FHYLCEENTG MVKLPTQKGD DAWKLYFDEI PEEIVDEFSM
2360 2370 2380 2390 2400
RYGIENIYQA MTHFHCLSAK YLCPGVPAVM STLLANINAY YAHTTASSAV
2410 2420 2430 2440 2450
SASDRFAASN FGKEKFVKLL DQLHNSLRID LSMYRNNFPA SSPEKLMDLK
2460 2470 2480 2490 2500
STVDLLTSIT FFRMKVQELS SPPRASTVVK DCVKACLRST YQFLFENCYE
2510 2520 2530 2540 2550
LYNREFQVDP NEAKRAPDDH EPKLDSVDFW HKLIALIVSV IDEDKNSYGT
2560 2570 2580 2590 2600
VLNQFPQELN IGQLSASSMW HLFAVDMKYA LEEHEQHRLC KSSAYMNLHF
2610 2620 2630 2640 2650
RVKWLYSNYV KEVPPYKGAV PDYPAWFEPF VMQWLNENDD VSLEYLHGAF
2660 2670 2680 2690 2700
KRDKKDGFQK SSEHALFSNS VVDVFTQLTQ CFDVVSKLEC PDPEIWKRYM
2710 2720 2730 2740 2750
RRFAKTIVKV LIAYADIVKL EFPEHMKDER IACILMNNIQ QLRVQLEKMF
2760 2770 2780 2790 2800
ESMGGDKLEE DAANILKELQ QNLNSALDDL ASQFAISLEP RITQSVRELG
2810 2820 2830 2840 2850
DMLLSIKGGS GTLAAGNLAA QRNAVAVEAD EVLRPLMDLL DGSLTLYAQS
2860 2870 2880 2890 2900
CEKTVLKRLL KELWKIVMRI LEKTIVLPPM TDKTMMFKHL TDNAKNLASN
2910 2920 2930 2940 2950
AKIEDMGRLF KSHMAGKQDV KSALSGVMDI SKEVEKNLSP KQCAVLDVAL
2960 2970 2980 2990 3000
DTIKQYFHAG GNGLKKTFLE KSPELQSLRY ALSLYTQMTD TLIKTFISSQ
3010 3020 3030 3040 3050
VHEVDLENSE ESVGEISVQI DLFSHPGTGE HKVNVKVVAA NDLKWQIPSG
3060 3070 3080 3090 3100
MFRPFVDINL IGPHLQEKKR KFATKSKSNN WSPKYNESFS FTIGNEEQLD
3110 3120 3130 3140 3150
FFELHICVKD YCFARDDRLV GVAVIPLKDI SEKGSVACWL PLMRRIEMDE
3160 3170 3180
TGWTILRILS QRNNDEVAKE FVKLKSEIRQ EPTMGT
Length:3,186
Mass (Da):360,416
Last modified:June 13, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1907D2AF98967460
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8IM86Q8IM86_DROME
Unc-13, isoform B
unc-13 Dmel\CG2999, drunc13, DUNC-13, Dunc-13, dUNC-13
3,183Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8IM87Q8IM87_DROME
Unc-13, isoform A
unc-13 Dmel\CG2999, drunc13, DUNC-13, Dunc-13, dUNC-13
2,871Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9V483Q9V483_DROME
Unc-13, isoform C
unc-13 Dmel\CG2999, drunc13, DUNC-13, Dunc-13, dUNC-13
2,874Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X2J9E1X2J9E1_DROME
Unc-13, isoform G
unc-13 Dmel\CG2999, drunc13, DUNC-13, Dunc-13, dUNC-13
2,871Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
L0MPR2L0MPR2_DROME
Unc-13, isoform F
unc-13 Dmel\CG2999, drunc13, DUNC-13, Dunc-13, dUNC-13
2,711Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014135 Genomic DNA Translation: AFH06787.1

NCBI Reference Sequences

More...
RefSeqi
NP_001245427.1, NM_001258498.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0308806; FBpp0300963; FBgn0025726

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
43841

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014135 Genomic DNA Translation: AFH06787.1
RefSeqiNP_001245427.1, NM_001258498.2

3D structure databases

SMRiH9XVP2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0300963

Proteomic databases

PaxDbiH9XVP2
PRIDEiH9XVP2

Genome annotation databases

EnsemblMetazoaiFBtr0308806; FBpp0300963; FBgn0025726
GeneIDi43841

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
43841
FlyBaseiFBgn0025726 unc-13

Phylogenomic databases

eggNOGiKOG1011 Eukaryota
ENOG410XS5D LUCA
GeneTreeiENSGT00940000168389
HOGENOMiCLU_000387_0_0_1
InParanoidiH9XVP2
PhylomeDBiH9XVP2

Enzyme and pathway databases

ReactomeiR-DME-181429 Serotonin Neurotransmitter Release Cycle
R-DME-181430 Norepinephrine Neurotransmitter Release Cycle
R-DME-210500 Glutamate Neurotransmitter Release Cycle
R-DME-212676 Dopamine Neurotransmitter Release Cycle
R-DME-264642 Acetylcholine Neurotransmitter Release Cycle

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
unc-13 fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
43841

Gene expression databases

BgeeiFBgn0025726 Expressed in head and 6 other tissues
ExpressionAtlasiH9XVP2 baseline and differential

Family and domain databases

CDDicd00029 C1, 1 hit
cd04027 C2B_Munc13, 1 hit
Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR010439 CAPS_dom
IPR014770 Munc13_1
IPR014772 Munc13_dom-2
IPR019558 Munc13_subgr_dom-2
IPR002219 PE/DAG-bd
IPR027080 Unc-13
IPR037302 Unc-13_C2B
PANTHERiPTHR10480 PTHR10480, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF00168 C2, 2 hits
PF06292 DUF1041, 1 hit
PF10540 Membr_traf_MHD, 1 hit
PRINTSiPR00360 C2DOMAIN
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00239 C2, 2 hits
SM01145 DUF1041, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS51258 MHD1, 1 hit
PS51259 MHD2, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9XVP2_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9XVP2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: February 26, 2020
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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