UniProtKB - H9NIL4 (H9NIL4_HUMAN)
Protein
Submitted name:
G protein-coupled receptor 21
Gene
RABGAP1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
GO - Biological processi
- glucose homeostasis Source: Ensembl
- negative regulation of insulin receptor signaling pathway Source: Ensembl
- positive regulation of multicellular organism growth Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Submitted name: G protein-coupled receptor 21ImportedSubmitted name: Rab GTPase-activating protein 1Imported |
Gene namesi | Name:RABGAP1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000011454.16 |
HGNCi | HGNC:17155, RABGAP1 |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 32 – 59 | HelicalSequence analysisAdd BLAST | 28 | |
Transmembranei | 71 – 92 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 104 – 125 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 146 – 169 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 189 – 214 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 253 – 274 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 286 – 307 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000011454, Expressed in secondary oocyte and 254 other tissues |
ExpressionAtlasi | H9NIL4, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 45 – 304 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 260 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
HOGENOMi | CLU_009579_3_3_1 |
OMAi | NSAFRKG |
OrthoDBi | 1099557at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
H9NIL4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNSTLDGNQS SHPFCLLAFG YLETVNFCLL EVLIIVFLTV LIISGNIIVI
60 70 80 90 100
FVFHCAPLLN HHTTSYFIQT MAYADLFVGV SCVVPSLSLL HHPLPVEESL
110 120 130 140 150
TCQIFGFVVS VLKSVSMASL ACISIDRYIA ITKPLTYNTL VTPWRLRLCI
160 170 180 190 200
FLIWLYSTLV FLPSFFHWGK PGYHGDVFQW CAESWHTDSY FTLFIVMMLY
210 220 230 240 250
APAALIVCFT YFNIFRICQQ HTKDISERQA RFSSQSGETG EVQACPDKRY
260 270 280 290 300
AMVLFRITSV FYILWLPYII YFLLESSTGH SNRFASFLTT WLAISNSFCN
310 320 330 340
CVIYSLSNSV FQRGLKRLSG AMCTSCASQT TANDPYTVRS KGPLNGCHI
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9Y3P9 | RBGP1_HUMAN | Rab GTPase-activating protein 1 | RABGAP1 HSPC094 | 1,069 | Annotation score: | ||
B5MCD9 | B5MCD9_HUMAN | Rab GTPase-activating protein 1 | RABGAP1 | 112 | Annotation score: | ||
C9JGR5 | C9JGR5_HUMAN | Rab GTPase-activating protein 1 | RABGAP1 | 66 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007066 Genomic DNA No translation available. AL358946 Genomic DNA No translation available. AL365338 Genomic DNA No translation available. JQ308169 Genomic DNA Translation: AFF59479.1 |
RefSeqi | NP_005285.1, NM_005294.2 XP_005251990.1, XM_005251933.3 |
Genome annotation databases
Ensembli | ENST00000616002; ENSP00000482287; ENSG00000011454 |
GeneIDi | 2844 |
KEGGi | hsa:2844 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007066 Genomic DNA No translation available. AL358946 Genomic DNA No translation available. AL365338 Genomic DNA No translation available. JQ308169 Genomic DNA Translation: AFF59479.1 |
RefSeqi | NP_005285.1, NM_005294.2 XP_005251990.1, XM_005251933.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
GPCRDBi | Search... |
Protocols and materials databases
Antibodypediai | 30396, 294 antibodies |
Genome annotation databases
Ensembli | ENST00000616002; ENSP00000482287; ENSG00000011454 |
GeneIDi | 2844 |
KEGGi | hsa:2844 |
Organism-specific databases
CTDi | 2844 |
EuPathDBi | HostDB:ENSG00000011454.16 |
HGNCi | HGNC:17155, RABGAP1 |
OpenTargetsi | ENSG00000011454 |
GenAtlasi | Search... |
Phylogenomic databases
HOGENOMi | CLU_009579_3_3_1 |
OMAi | NSAFRKG |
OrthoDBi | 1099557at2759 |
Miscellaneous databases
BioGRID-ORCSi | 2844, 2 hits in 837 CRISPR screens |
ChiTaRSi | RABGAP1, human |
GenomeRNAii | 2844 |
Gene expression databases
Bgeei | ENSG00000011454, Expressed in secondary oocyte and 254 other tissues |
ExpressionAtlasi | H9NIL4, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H9NIL4_HUMAN | |
Accessioni | H9NIL4Primary (citable) accession number: H9NIL4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 13, 2012 |
Last sequence update: | June 13, 2012 | |
Last modified: | December 2, 2020 | |
This is version 59 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |