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UniProtKB - H9KV90 (H9KV90_HUMAN)
Protein
Submitted name:
SH3 and multiple ankyrin repeat domains protein 1
Gene
SHANK1
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: SH3 and multiple ankyrin repeat domains protein 1Imported |
Gene namesi | Name:SHANK1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15474, SHANK1 |
VEuPathDBi | HostDB:ENSG00000161681 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm ARBA annotation
Other locations
- postsynaptic density ARBA annotation
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- cytoplasm Source: UniProtKB-SubCell
- postsynaptic density Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell junction, SynapseARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000161681, Expressed in dorsolateral prefrontal cortex and 108 other tissues |
ExpressionAtlasi | H9KV90, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 246 – 278 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 313 – 345 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 346 – 378 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Domaini | 554 – 613 | SH3InterPro annotationAdd BLAST | 60 | |
Domaini | 663 – 757 | PDZInterPro annotationAdd BLAST | 95 | |
Domaini | 2106 – 2169 | SAMInterPro annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 53 | DisorderedSequence analysisAdd BLAST | 53 | |
Regioni | 412 – 433 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 455 – 546 | DisorderedSequence analysisAdd BLAST | 92 | |
Regioni | 766 – 790 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 840 – 894 | DisorderedSequence analysisAdd BLAST | 55 | |
Regioni | 917 – 1237 | DisorderedSequence analysisAdd BLAST | 321 | |
Regioni | 1249 – 1297 | DisorderedSequence analysisAdd BLAST | 49 | |
Regioni | 1361 – 1728 | DisorderedSequence analysisAdd BLAST | 368 | |
Regioni | 1742 – 1793 | DisorderedSequence analysisAdd BLAST | 52 | |
Regioni | 1835 – 1868 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 1900 – 1991 | DisorderedSequence analysisAdd BLAST | 92 | |
Regioni | 2004 – 2029 | DisorderedSequence analysisAdd BLAST | 26 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 20 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 459 – 495 | Polar residuesSequence analysisAdd BLAST | 37 | |
Compositional biasi | 500 – 514 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 925 – 946 | Pro residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 1004 – 1025 | Basic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 1033 – 1050 | Pro residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1133 – 1155 | Pro residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 1166 – 1191 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 1209 – 1228 | Pro residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1381 – 1398 | Pro residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1521 – 1538 | Pro residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1590 – 1621 | Pro residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 1624 – 1644 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 1651 – 1678 | Pro residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 1693 – 1711 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 1848 – 1864 | Pro residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1919 – 1949 | Polar residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 1971 – 1991 | Polar residuesSequence analysisAdd BLAST | 21 |
Keywords - Domaini
ANK repeatPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000153561 |
OrthoDBi | 468249at2759 |
PhylomeDBi | H9KV90 |
Family and domain databases
Gene3Di | 1.10.150.50, 1 hit 1.25.40.20, 1 hit 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR001478, PDZ IPR041489, PDZ_6 IPR036034, PDZ_sf IPR001660, SAM IPR013761, SAM/pointed_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits PF17820, PDZ_6, 1 hit PF00536, SAM_1, 1 hit PF07653, SH3_2, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 6 hits SM00228, PDZ, 1 hit SM00454, SAM, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF48403, SSF48403, 1 hit SSF50044, SSF50044, 1 hit SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50088, ANK_REPEAT, 3 hits PS50106, PDZ, 1 hit PS50105, SAM_DOMAIN, 1 hit PS50002, SH3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
H9KV90-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTHSPATSED EERHSASECP EGGSESDSSP DGPGRGPRGT RGQGSGAPGS
60 70 80 90 100
LASVRGLQGR SMSVPDDAHF SMMVFRIGIP DLHQTKCLRF NPDATIWTAK
110 120 130 140 150
QQVLCALSES LQDVLNYGLF QPATSGRDAN FLEEERLLRE YPQSFEKGVP
160 170 180 190 200
YLEFRYKTRV YKQTNLDEKQ LAKLHTKTGL KKFLEYVQLG TSDKVARLLD
210 220 230 240 250
KGLDPNYHDS DSGETPLTLA AQTEGSVEVI RTLCLGGAHI DFRARDGMTA
260 270 280 290 300
LHKAACARHC LALTALLDLG GSPNYKDRRG LTPLFHTAMV GGDPRCCELL
310 320 330 340 350
LFNRAQLGIA DENGWQEIHQ ACQRGHSQHL EHLLFYGAEP GAQNASGNTA
360 370 380 390 400
LHICALYNKE TCARILLYRG ADKDVKNNNG QTPFQVAVIA GNFELGELIR
410 420 430 440 450
NHREQDVVPF QESPKYAARR RGPPGTGLTV PPALLRANSD TSMALPDWMV
460 470 480 490 500
FSAPGAASSG APGPTSGSQG QSQPSAPTTK LSSGTLRSAS SPRGARARSP
510 520 530 540 550
SRGRHPEDAK RQPRGRPSSS GTPREGPAGG TGGSGGPGGS LGSRGRRRKL
560 570 580 590 600
YSAVPGRSFM AVKSYQAQAE GEISLSKGEK IKVLSIGEGG FWEGQVKGRV
610 620 630 640 650
GWFPSDCLEE VANRSQESKQ ESRSDKAKRL FRHYTVGSYD SFDAPSLMDG
660 670 680 690 700
IGPGSDYIIK EKTVLLQKKD SEGFGFVLRG AKAQTPIEEF TPTPAFPALQ
710 720 730 740 750
YLESVDEGGV AWRAGLRMGD FLIEVNGQNV VKVGHRQVVN MIRQGGNTLM
760 770 780 790 800
VKVVMVTRHP DMDEAVHKKA PQQAKRLPPP TISLRSKSMT SELEEMVSPW
810 820 830 840 850
KKKSEYEQQP APVPSMEKKR TVYQMALNKL DEILAAAQQT ISASESPGPG
860 870 880 890 900
GLASLGKHRP KGFFATESSF DPHHRAQPSY ERPSFLPPGP GLMLRQKSIG
910 920 930 940 950
AAEDDRPYLA PPAMKFSRSL SVPGSEDIPP PPTTSPPEPP YSTPPVPSSS
960 970 980 990 1000
GRLTPSPRGG PFNPGSGGPL PASSPASFDG PSPPDTRVGS REKSLYHSGP
1010 1020 1030 1040 1050
LPPAHHHPPH HHHHHAPPPQ PHHHHAHPPH PPEMETGGSP DDPPPRLALG
1060 1070 1080 1090 1100
PQPSLRGWRG GGPSPTPGAP SPSHHGSAGG GGGSSQGPAL RYFQLPPRAA
1110 1120 1130 1140 1150
SAAMYVPARS GRGRKGPLVK QTKVEGEPQK GGGLPPAPSP TSPASPQPPP
1160 1170 1180 1190 1200
AVAAPSEKNS IPIPTIIIKA PSTSSSGRSS QGSSTEAEPP TQPEPTGGGG
1210 1220 1230 1240 1250
GGGSSPSPAP AMSPVPPSPS PVPTPASPSG PATLDFTSQF GAALVGAARR
1260 1270 1280 1290 1300
EGGWQNEARR RSTLFLSTDA GDEDGGDGGL GTGAAPGPRL RHSKSIDEGM
1310 1320 1330 1340 1350
FSAEPYLRLE SAGSGAGYGG YGAGSRAYGG GGGSSAFTSF LPPRPLVHPL
1360 1370 1380 1390 1400
TGKALDPASP LGLALAARER ALKESSEGGG APQPPPRPPS PRYEAPPPTP
1410 1420 1430 1440 1450
HHHSPHAHHE PVLRLWGASP PDPARRELGY RAGLGSQEKS LPASPPAARR
1460 1470 1480 1490 1500
SLLHRLPPTA PGVGPLLLQL GTEPPAPHPG VSKPWRSAAP EEPERLPLHV
1510 1520 1530 1540 1550
RFLENCQPRA PVTSGRGPPS EDGPGVPPPS PRRSVPPSPT SPRASEENGL
1560 1570 1580 1590 1600
PLLVLPPPAP SVDVEDGEFL FVEPLPPPLE FSNSFEKPES PLTPGPPHPL
1610 1620 1630 1640 1650
PDTPAPATPL PPVPPPAVAA APPTLDSTAS SLTSYDSEVA TLTQGASAAP
1660 1670 1680 1690 1700
GDPHPPGPPA PAAPAPAAPQ PGPDPPPGTD SGIEEVDSRS SSDHPLETIS
1710 1720 1730 1740 1750
SASTLSSLSA EGGGSAGGGG GAGAGVASGP ELLDTYVAYL DGQAFGGSST
1760 1770 1780 1790 1800
PGPPYPPQLM TPSKLRGRAL GASGGLRPGP SGGLRDPVTP TSPTVSVTGA
1810 1820 1830 1840 1850
GTDGLLALRA CSGPPTAGVA GGPVAVEPEV PPVPLPTASS LPRKLLPWEE
1860 1870 1880 1890 1900
GPGPPPPPLP GPLAQPQASA LATVKASIIS ELSSKLQQFG GSSAAGGALP
1910 1920 1930 1940 1950
WARGGSGGGG DSHHGGASYV PERTSSLQRQ RLSDDSQSSL LSKPVSSLFQ
1960 1970 1980 1990 2000
NWPKPPLPPL PTGTGVSPTA AAAPGATSPS ASSSSTSTRH LQGVEFEMRP
2010 2020 2030 2040 2050
PLLRRAPSPS LLPASEHKVS PAPRPSSLPI LPSGPLYPGL FDIRGSPTGG
2060 2070 2080 2090 2100
AGGSADPFAP VFVPPHPGIS GGLGGALSGA SRSLSPTRLL SLPPDKPFGA
2110 2120 2130 2140 2150
KPLGFWTKFD VADWLEWLGL AEHRAQFLDH EIDGSHLPAL TKEDYVDLGV
2160
TRVGHRMNID RALKFFLER
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9Y566 | SHAN1_HUMAN | SH3 and multiple ankyrin repeat dom... | SHANK1 | 2,161 | Annotation score: | ||
M0QYB5 | M0QYB5_HUMAN | SH3 and multiple ankyrin repeat dom... | SHANK1 | 183 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008743 Genomic DNA No translation available. AC010325 Genomic DNA No translation available. |
RefSeqi | XP_011525315.1, XM_011527013.2 |
Genome annotation databases
Ensembli | ENST00000391814; ENSP00000375690; ENSG00000161681 |
GeneIDi | 50944 |
UCSCi | uc061bsa.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008743 Genomic DNA No translation available. AC010325 Genomic DNA No translation available. |
RefSeqi | XP_011525315.1, XM_011527013.2 |
3D structure databases
SMRi | H9KV90 |
ModBasei | Search... |
Proteomic databases
MaxQBi | H9KV90 |
PRIDEi | H9KV90 |
ProteomicsDBi | 46239 |
Protocols and materials databases
Antibodypediai | 18886, 231 antibodies from 27 providers |
DNASUi | 50944 |
Genome annotation databases
Ensembli | ENST00000391814; ENSP00000375690; ENSG00000161681 |
GeneIDi | 50944 |
UCSCi | uc061bsa.1, human |
Organism-specific databases
CTDi | 50944 |
HGNCi | HGNC:15474, SHANK1 |
OpenTargetsi | ENSG00000161681 |
VEuPathDBi | HostDB:ENSG00000161681 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000153561 |
OrthoDBi | 468249at2759 |
PhylomeDBi | H9KV90 |
Miscellaneous databases
BioGRID-ORCSi | 50944, 2 hits in 1039 CRISPR screens |
ChiTaRSi | SHANK1, human |
GenomeRNAii | 50944 |
Gene expression databases
Bgeei | ENSG00000161681, Expressed in dorsolateral prefrontal cortex and 108 other tissues |
ExpressionAtlasi | H9KV90, baseline and differential |
Family and domain databases
Gene3Di | 1.10.150.50, 1 hit 1.25.40.20, 1 hit 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR001478, PDZ IPR041489, PDZ_6 IPR036034, PDZ_sf IPR001660, SAM IPR013761, SAM/pointed_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits PF17820, PDZ_6, 1 hit PF00536, SAM_1, 1 hit PF07653, SH3_2, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 6 hits SM00228, PDZ, 1 hit SM00454, SAM, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF48403, SSF48403, 1 hit SSF50044, SSF50044, 1 hit SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50088, ANK_REPEAT, 3 hits PS50106, PDZ, 1 hit PS50105, SAM_DOMAIN, 1 hit PS50002, SH3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | H9KV90_HUMAN | |
Accessioni | H9KV90Primary (citable) accession number: H9KV90 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | May 16, 2012 | |
Last modified: | January 19, 2022 | |
This is version 75 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |