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Entry version 47 (13 Nov 2019)
Sequence version 1 (16 May 2012)
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Protein
Submitted name:

Ninein

Gene

NIN

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
NineinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NINImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14906 NIN

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000100503

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
H9KV85

MaxQB - The MaxQuant DataBase

More...
MaxQBi
H9KV85

PeptideAtlas

More...
PeptideAtlasi
H9KV85

PRoteomics IDEntifications database

More...
PRIDEi
H9KV85

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
46234

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100503 Expressed in 199 organ(s), highest expression level in amniotic fluid

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
H9KV85 baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni67 – 89DisorderedSequence analysisAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili21 – 55Sequence analysisAdd BLAST35
Coiled coili124 – 180Sequence analysisAdd BLAST57
Coiled coili189 – 212Sequence analysisAdd BLAST24
Coiled coili258 – 300Sequence analysisAdd BLAST43
Coiled coili324 – 373Sequence analysisAdd BLAST50
Coiled coili396 – 416Sequence analysisAdd BLAST21
Coiled coili453 – 480Sequence analysisAdd BLAST28
Coiled coili489 – 516Sequence analysisAdd BLAST28
Coiled coili565 – 585Sequence analysisAdd BLAST21
Coiled coili677 – 711Sequence analysisAdd BLAST35
Coiled coili743 – 791Sequence analysisAdd BLAST49
Coiled coili938 – 962Sequence analysisAdd BLAST25
Coiled coili979 – 1027Sequence analysisAdd BLAST49
Coiled coili1049 – 1111Sequence analysisAdd BLAST63
Coiled coili1121 – 1141Sequence analysisAdd BLAST21
Coiled coili1200 – 1220Sequence analysisAdd BLAST21
Coiled coili1245 – 1307Sequence analysisAdd BLAST63
Coiled coili1347 – 1374Sequence analysisAdd BLAST28
Coiled coili1420 – 1440Sequence analysisAdd BLAST21
Coiled coili1485 – 1512Sequence analysisAdd BLAST28
Coiled coili1531 – 1555Sequence analysisAdd BLAST25

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IK59 Eukaryota
ENOG410Z1RR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00660000095541

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029664 NIN

The PANTHER Classification System

More...
PANTHERi
PTHR18905:SF11 PTHR18905:SF11, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

H9KV85-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XVLAEKFGDL DPSSAEFFLQ EERLTQMRNE YERQCRVLQD QVDELQSELE
60 70 80 90 100
EYRAQGRVLR LPLKNSPSEE VEANSGGIEP EHGLGSEECN PLNMSIEAEL
110 120 130 140 150
VIEQMKEQHH RDICCLRLEL EDKVRHYEKQ LDETVVSCKK AQENMKQRHE
160 170 180 190 200
NETHTLEKQI SDLKNEIAEL QGQAAVLKEA HHEATCRHEE EKKQLQVKLE
210 220 230 240 250
EEKTHLQEKL RLQHEMELKA RLTQAQASFE REREGLQSSA WTEEKVRGLT
260 270 280 290 300
QELEQFHQEQ LTSLVEKHTL EKEELRKELL EKHQRELQEG REKMETECNR
310 320 330 340 350
RTSQIEAQFQ SDCQKVTERC ESALQSLEGR YRQELKDLQE QQREEKSQWE
360 370 380 390 400
FEKDELTQEC AEAQELLKET LKREKTTSLV LTQEREMLEK TYKEHLNSMV
410 420 430 440 450
VERQQLLQDL EDLRNVSETQ QSLLSDQILE LKSSHKRELR EREEVLCQAG
460 470 480 490 500
ASEQLASQRL ERLEMEHDQE RQEMMSKLLA MENIHKATCE TADRERAEMS
510 520 530 540 550
TEISRLQSKI KEMQQATSPL SMLQSGCQVI GEEEVEGDGA LSLLQQGEQL
560 570 580 590 600
LEENGDVLLS LQRAHEQAVK ENVKMATEIS RLQQRLQKLE PGLVMSSCLD
610 620 630 640 650
EPATEFFGNT AEQTEQFLQQ NRTKQVEGVT RRHVLSDLED DEVRDLGSTG
660 670 680 690 700
TSSVQRQEVK IEESEASVEG FSELENSEET RTESWELKNQ ISQLQEQLMM
710 720 730 740 750
LCADCDRASE KKQDLLFDVS VLKKKLKMLE RIPEASPKYK LLYEDVSREN
760 770 780 790 800
DCLQEELRMM ETRYDEALEN NKELTAEVFR LQDELKKMEE VTETFLSLEK
810 820 830 840 850
SYDEVKIENE GLNVLVLRLQ GKIEKLQESV VQRCDCCLWE ASLENLEIEP
860 870 880 890 900
DGNILQLNQT LEECVPRVRS VHHVIEECKQ ENQYLEGNTQ LLEKVKAHEI
910 920 930 940 950
AWLHGTIQTH QERPRVQNQV ILEENTTLLG FQDKHFQHQA TIAELELEKT
960 970 980 990 1000
KLQELTRKLK ERVTILVKQK DVLSHGEKEE ELKAMMHDLQ ITCSEMQQKV
1010 1020 1030 1040 1050
ELLRYESEKL QQENSILRNE ITTLNEEDSI SNLKLGTLNG SQEEMWQKTE
1060 1070 1080 1090 1100
TVKQENAAVQ KMVENLKKQI SELKIKNQQL DLENTELSQK NSQNQEKLQE
1110 1120 1130 1140 1150
LNQRLTEMLC QKEKEPGNSA LEEREQEKFN LKEELERCKV QSSTLVSSLE
1160 1170 1180 1190 1200
AELSEVKIQT HIVQQENHLL KDELEKMKQL HRCPDLSDFQ QKISSVLSYN
1210 1220 1230 1240 1250
EKLLKEKEAL SEELNSCVDK LAKSSLLEHR IATMKQEQKS WEHQSASLKS
1260 1270 1280 1290 1300
QLVASQEKVQ NLEDTVQNVN LQMSRMKSDL RVTQQEKEAL KQEVMSLHKQ
1310 1320 1330 1340 1350
LQNAGGKSWA PEIATHPSGL HNQQKRLSWD KLDHLMNEEQ QLLWQENERL
1360 1370 1380 1390 1400
QTMVQNTKAE LTHSREKVRQ LESNLLPKHQ KHLNPSGTMN PTEQEKLSLK
1410 1420 1430 1440 1450
RECDQFQKEQ SPANRKVSQM NSLEQELETI HLENEGLKKK QVKLDEQLME
1460 1470 1480 1490 1500
MQHLRSTATP SPSPHAWDLQ LLQQQACPMV PREQFLQLQR QLLQAERINQ
1510 1520 1530 1540 1550
HLQEELENRT SETNTPQGNQ EQLVTVMEER MIEVEQKLKL VKRLLQEKVN
1560 1570 1580
QLKEQVSLPG HLCSPTSHSS FNSSFTSLYC H
Length:1,581
Mass (Da):184,608
Last modified:May 16, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i05490E1B2F182A12
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8N4C6NIN_HUMAN
Ninein
NIN KIAA1565
2,090Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J066C9J066_HUMAN
Ninein
NIN
2,046Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDJ4H0YDJ4_HUMAN
Ninein
NIN
1,537Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PN67E9PN67_HUMAN
Ninein
NIN
1,989Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4J215A0A0B4J215_HUMAN
Ninein
NIN
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJH9E9PJH9_HUMAN
Ninein
NIN
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C162H7C162_HUMAN
Ninein
NIN
396Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GN85R4GN85_HUMAN
Ninein
NIN
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL133485 Genomic DNA No translation available.
AL606834 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000389869; ENSP00000374519; ENSG00000100503

UCSC genome browser

More...
UCSCi
uc059bkk.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133485 Genomic DNA No translation available.
AL606834 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Proteomic databases

jPOSTiH9KV85
MaxQBiH9KV85
PeptideAtlasiH9KV85
PRIDEiH9KV85
ProteomicsDBi46234

Genome annotation databases

EnsembliENST00000389869; ENSP00000374519; ENSG00000100503
UCSCiuc059bkk.1 human

Organism-specific databases

HGNCiHGNC:14906 NIN
OpenTargetsiENSG00000100503

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IK59 Eukaryota
ENOG410Z1RR LUCA
GeneTreeiENSGT00660000095541

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NIN human

Gene expression databases

BgeeiENSG00000100503 Expressed in 199 organ(s), highest expression level in amniotic fluid
ExpressionAtlasiH9KV85 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR029664 NIN
PANTHERiPTHR18905:SF11 PTHR18905:SF11, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9KV85_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9KV85
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: November 13, 2019
This is version 47 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
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