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Entry version 33 (12 Aug 2020)
Sequence version 1 (16 May 2012)
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Protein

Protein mesh

Gene
N/A
Organism
Bombyx mori (Silk moth)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be required for the proper organization of smooth septate junctions and for the barrier function of the midgut epithelium.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein mesh1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBombyx mori (Silk moth)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7091 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaLepidopteraGlossataDitrysiaBombycoideaBombycidaeBombycinaeBombyx
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005204 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 1182ExtracellularSequence analysisAdd BLAST1161
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1183 – 1203HelicalSequence analysisAdd BLAST21
Topological domaini1204 – 1472CytoplasmicSequence analysisAdd BLAST269
Transmembranei1473 – 1493HelicalSequence analysisAdd BLAST21
Topological domaini1494 – 1583ExtracellularSequence analysisAdd BLAST90

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000042394722 – 1583Protein meshSequence analysisAdd BLAST1562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1112 ↔ 1152By similarity
Disulfide bondi1138 ↔ 1168By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
H9JIQ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In fifth instar larvae, expressed in midgut epithelial cells (at protein level).1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7091.BGIBMGA009402-TA

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
H9JIQ1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini260 – 415NIDOPROSITE-ProRule annotationAdd BLAST156
Domaini647 – 798AMOPPROSITE-ProRule annotationAdd BLAST152
Domaini812 – 1054VWFDPROSITE-ProRule annotationAdd BLAST243
Domaini1110 – 1170SushiPROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4291, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003648_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H9JIQ1

Identification of Orthologs from Complete Genome Data

More...
OMAi
DKNDYLM

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033, CCP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005533, AMOP_dom
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR003886, NIDO_dom
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
IPR001846, VWF_type-D

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03782, AMOP, 1 hit
PF06119, NIDO, 1 hit
PF00084, Sushi, 1 hit
PF00094, VWD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00723, AMOP, 1 hit
SM00032, CCP, 1 hit
SM00539, NIDO, 1 hit
SM00216, VWD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57535, SSF57535, 1 hit
SSF81296, SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50856, AMOP, 1 hit
PS51220, NIDO, 1 hit
PS50923, SUSHI, 1 hit
PS51233, VWFD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

H9JIQ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGVKIKLVLA VVLILSANVL GQDEIVNDTE STVSVTEAQV VELETDVKEK
60 70 80 90 100
EDETFEETSP VELLPDTENL EVRSGKYQLN DGLVGEEPVN LEAVDFNSNN
110 120 130 140 150
VESEKQLLSP PSTTVVTGTD YSYIDGRVLP ATTYQNNGQP YVITTQRLQQ
160 170 180 190 200
IRSNFMYWFY DQGGSDNIGD YQRDIHTSTP QIHKNFNFQL PFFGFRFNYT
210 220 230 240 250
RISMNGYIYF SDPPDHYTYP LSFPVRDWPN INDPSFIGIF FSKCRIGNMR
260 270 280 290 300
PEEPDPRRPG IYFRLDRDLQ TRTDQLGVEM RERVTWDIRE GVIGSETFFP
310 320 330 340 350
KHTITITWKN MSFAGGIDNS LFMTNTFQMV LATDEVFTYA IFNYLEINWS
360 370 380 390 400
SHTEAGGDTT TGEGGIPAYI GFNAGNGTRS YEYKPYSQAS VLRDLTGRGW
410 420 430 440 450
ANGFPGRHIF RIDENILMGT CNKDIDGANL PLMFAPESGN MLGGTIVNIT
460 470 480 490 500
GPCFNPNDRI TCRFDTESVL GAVVDVNRAI CVQPRFWHNG YARFEVAINN
510 520 530 540 550
EPYKWKGRYF VETPATATEK IFFPDNSVHE RYPPEVRITW DRFNLTTNLN
560 570 580 590 600
VQLQISLWGY KEVTIRPQLE YIDMIEVGVA NTGEYVINPQ NFRNRENIMH
610 620 630 640 650
NDMQFGFLQI NLTTPEVFKG VPISPILWSR PIPLGWYFAP QWERLHGQRW
660 670 680 690 700
SNSMCNNWLR TDRFLKNFAA QVWVCPCTLE HALLDKGRFM PDLDCDRDTN
710 720 730 740 750
PTCRYHWGGI HCVRSGAPSS EGSGQQCCYD KNGFLMLSYD QMWGSKPSRS
760 770 780 790 800
HDFGFTPYNE ANKVPSLSRW FHDMIPFYQC CLWQEEQAVG CETFRFERRP
810 820 830 840 850
SQDCVAYQSP GVAGIFGDPH IVTFDDLQYT FNGKGEYVLV RVDHSQLKLD
860 870 880 890 900
VQGRFEQVPR NIHGAVNATH LTSVVAASNN SQTIEVRLRP QHAQWRYRLD
910 920 930 940 950
VFANGKRVYF DRTALRVQYF PGVTVYQPMY VLNQSEIVVM FSSGAGLEVV
960 970 980 990 1000
ENRGFMTARV YLPWTFMNQT RGLFGNWSLD VNDDFTRPDG TLASVDLNNF
1010 1020 1030 1040 1050
QSAHRDFAQH WQLTDREQRD IGVAMFVREY GRTAAYYNDN EFIPNFIREP
1060 1070 1080 1090 1100
ANFLPVNRSH DVTRAIEICQ DSYQCRYDYG MTLNRDMAEF TKNYLSSITN
1110 1120 1130 1140 1150
IKEQNARRVI SCGILETPRF GRKSNFFFTP GTRVNFECNQ DFILTGDKRR
1160 1170 1180 1190 1200
VCEDNGRWNL PDYGYTECLR QQEFSQRALF LTWGVIVAVI LPLGLLICLL
1210 1220 1230 1240 1250
WFWCWHKPRS EGKEGFRFED LPRSKSASRL NLRSSSMGNI TDTMKSSTIP
1260 1270 1280 1290 1300
GSEKKSPETP TEETPARIVG RSVLAPPADG DSSGIGYPDS GKSDSGKSDK
1310 1320 1330 1340 1350
SSGLPKKRRA YDKTYRTNEP LPNAPDVEFP EKLWDLSEED LLSLTSPSDS
1360 1370 1380 1390 1400
ESNRDSTLTR PAKDIQYLNK PRQTGRQAIP SDSGYSTKEG SEDPYAPKFD
1410 1420 1430 1440 1450
DQYSPIPSQY SPTYSEIYSP PISPASDSSP RNTYNNPGIP EAPKSAPVDG
1460 1470 1480 1490 1500
IKTFTMPTNK GKQEYSSRTL GATWGIISAV MLPIIIILIC VAWRILQRRK
1510 1520 1530 1540 1550
AEEREENEFL DVKTRAIDPD DSVKVTSDDE SIPYKKDVTE ETPEPTEGVQ
1560 1570 1580
AVEPSNPNYN YGRPYVDLQP GQPRQWGGET EIN
Length:1,583
Mass (Da):180,588
Last modified:May 16, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA8EF77955E425EEC
GO

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
BGIBMGA009402-RA; BGIBMGA009402-TA; BGIBMGA009402

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

SMRiH9JIQ1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7091.BGIBMGA009402-TA

Proteomic databases

PRIDEiH9JIQ1

Genome annotation databases

EnsemblMetazoaiBGIBMGA009402-RA; BGIBMGA009402-TA; BGIBMGA009402

Phylogenomic databases

eggNOGiKOG4291, Eukaryota
HOGENOMiCLU_003648_1_0_1
InParanoidiH9JIQ1
OMAiDKNDYLM

Family and domain databases

CDDicd00033, CCP, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR005533, AMOP_dom
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR003886, NIDO_dom
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
IPR001846, VWF_type-D
PfamiView protein in Pfam
PF03782, AMOP, 1 hit
PF06119, NIDO, 1 hit
PF00084, Sushi, 1 hit
PF00094, VWD, 1 hit
SMARTiView protein in SMART
SM00723, AMOP, 1 hit
SM00032, CCP, 1 hit
SM00539, NIDO, 1 hit
SM00216, VWD, 1 hit
SUPFAMiSSF57535, SSF57535, 1 hit
SSF81296, SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50856, AMOP, 1 hit
PS51220, NIDO, 1 hit
PS50923, SUSHI, 1 hit
PS51233, VWFD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMESH_BOMMO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9JIQ1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: May 16, 2012
Last modified: August 12, 2020
This is version 33 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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