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Entry version 34 (16 Oct 2019)
Sequence version 2 (30 Nov 2016)
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Protein
Submitted name:

FA complementation group D2

Gene

FANCD2

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
FA complementation group D2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FANCD2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacaca mulatta (Rhesus macaque)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9544 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006718 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMMUG00000008966 Expressed in 15 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
H9H4F8 baseline

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 37DisorderedSequence analysisAdd BLAST37
Regioni828 – 866DisorderedSequence analysisAdd BLAST39
Regioni1356 – 1390DisorderedSequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 26PolyampholyteSequence analysisAdd BLAST26

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4712 Eukaryota
ENOG410XT6B LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016970

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H9H4F8

TreeFam database of animal gene trees

More...
TreeFami
TF350409

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11721 FANCD2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029448 FANCD2

The PANTHER Classification System

More...
PANTHERi
PTHR32086 PTHR32086, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14631 FancD2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

H9H4F8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSKRRLSKS EDKESLIEDA SKTRKQPLSK KTKKSHIGNE VEENDSIFVK
60 70 80 90 100
LLKISGIILK TGENQNQLAV DQIAFQKKLF QTLRRHPSYP KIIEEFVSGL
110 120 130 140 150
ESYIEDEDSF RNCLLPCERL QDEEASMGAS YSKSLIKLLL GIDILQVRLK
160 170 180 190 200
ANKNSDEINV PRLIVSQLKW LDRVVDGKDL TAKIMQLISI APENLQHDII
210 220 230 240 250
TSLPEILGDS QHTDVGKELS DLLIENTSLT VPILDVLSSL RLDPNFLLKV
260 270 280 290 300
RQLVMDKLSS IRLEDLPVII KFILHSITAM DALEVISELR EKLDLQHCVL
310 320 330 340 350
PSRLQASQVK LKSKGRASSS GNQESSDQSC IILLFDVIKS AIRYEKTISE
360 370 380 390 400
AWIKAIENTA SVSEHKVFDL VMLFIIYSTN TQTKKYIERV LRNKIRSGCI
410 420 430 440 450
QEQLLQSTFS VHYLVLKDMC SSILSLAQSL LHSLDQSIIS FGSLLYKYAF
460 470 480 490 500
KFFDTYCQQE VVGALVTHIC SGNEAEVDTA LDVLLELVVL NPSAMMMNAV
510 520 530 540 550
FVKGILDYLD NISPQQIRKL FYVLSTLAFS KQNEASSHIQ DDMHLVIRKQ
560 570 580 590 600
LSSTVFKYKL IGIIGAVTMA GIMAADRSSQ GLNCSSSLLQ VTSLLQLVHS
610 620 630 640 650
CSEQSPQASA LYYDEFANLI QQEKLDPKAL ERVGHTICSD FQDAFVVDSC
660 670 680 690 700
VVPEGDFPFP VKALYGLEEH NTQDGIAINL LPLLFSQDFA KDGGPVTPQE
710 720 730 740 750
SGQKLVSPLC LAPYFRLLRL CVERQHNGNL EEIDGLLDCP IFLTDLEPGE
760 770 780 790 800
KLESMSAKER AFMCSLLFLT LNWFREVSRV NRIFNLLFVS VTPDYIPPLG
810 820 830 840 850
NFDVETLDIT PHTVTAISAK IRKKGKIERK QKADGSKTSS SDTISEEKNS
860 870 880 890 900
ECDPTPSHRG QMNKEFTGKE EKTSLLLHNY HAFFRELDIE VFSILHCGLV
910 920 930 940 950
TKFILDTEMH TEATEVVQLG PPELLFLLED LSQKLESMLT PPIARRVPFF
960 970 980 990 1000
KNKGSRNIGF SHLQQRSAQE IVHCVFQLVT PMCNHLENIH NYFQCLAAEN
1010 1020 1030 1040 1050
HGVVDGPGMK VQEYHIMSSC YQRLLQIFHG LFAWSGFSQP ENQNLLYSAL
1060 1070 1080 1090 1100
HVLSSRLKQG EHSQPLEELL SQSFHYLQNF HQSIPSFQCA LYLIRLLMVI
1110 1120 1130 1140 1150
LEKSTASTQN KEKIASLARQ FLCRVWPSGD KEKSSISNDQ LHALLCIYLE
1160 1170 1180 1190 1200
HTDSILKAIE EIAGVGVPEL INSPKDVSSS TFPTLTRHTF VVFFRVMMAE
1210 1220 1230 1240 1250
LEKTVKKIEP GTAADSQQIH EEKLLYWNMA VRDFSILINL IKVFDSHPVL
1260 1270 1280 1290 1300
HVCLKYGRLF VEAFLKQCMP LLDFSFRKHR EDVLSLLETF QLDTRLLHHL
1310 1320 1330 1340 1350
CGHSKIHQDT RLTQHVPLLK KTLELLVCRV KAMLTLNNCR EAFWLGNLKN
1360 1370 1380 1390 1400
RDLQGEEIKS QNSQESTADE SEDDMSSQAS KSKATEVSLQ KAPESGTDGC
1410 1420 1430
ILLIVLSWWS RTLPTYVYCQ VLLCPFPFPP
Length:1,430
Mass (Da):161,699
Last modified:November 30, 2016 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF37928006536D59
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5RHD5A0A1D5RHD5_MACMU
FA complementation group D2
FANCD2
1,445Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H9H3A1H9H3A1_MACMU
FA complementation group D2
FANCD2
1,425Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7HU77F7HU77_MACMU
FA complementation group D2
FANCD2
241Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5QGI3A0A1D5QGI3_MACMU
FA complementation group D2
FANCD2
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JSUE03023217 Genomic DNA No translation available.
JSUE03023218 Genomic DNA No translation available.
JSUE03023219 Genomic DNA No translation available.
JSUE03023220 Genomic DNA No translation available.
JSUE03023221 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMMUT00000039162; ENSMMUP00000032245; ENSMMUG00000008966

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JSUE03023217 Genomic DNA No translation available.
JSUE03023218 Genomic DNA No translation available.
JSUE03023219 Genomic DNA No translation available.
JSUE03023220 Genomic DNA No translation available.
JSUE03023221 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSMMUT00000039162; ENSMMUP00000032245; ENSMMUG00000008966

Phylogenomic databases

eggNOGiKOG4712 Eukaryota
ENOG410XT6B LUCA
GeneTreeiENSGT00390000016970
InParanoidiH9H4F8
TreeFamiTF350409

Gene expression databases

BgeeiENSMMUG00000008966 Expressed in 15 organ(s), highest expression level in testis
ExpressionAtlasiH9H4F8 baseline

Family and domain databases

CDDicd11721 FANCD2, 1 hit
InterProiView protein in InterPro
IPR029448 FANCD2
PANTHERiPTHR32086 PTHR32086, 1 hit
PfamiView protein in Pfam
PF14631 FancD2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9H4F8_MACMU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9H4F8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: November 30, 2016
Last modified: October 16, 2019
This is version 34 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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