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UniProtKB - H9GS46 (H9GS46_ANOCA)

Entry version 47 (07 Oct 2020)
Sequence version 2 (26 Jun 2013)
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Protein

AAA domain-containing protein

Gene

ATAD5

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AAA domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATAD5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSACAG00000009606, Expressed in forelimb bud and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		28377.ENSACAP00000019218

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1065 – 1289AAAInterPro annotationAdd BLAST225

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 28DisorderedSequence analysisAdd BLAST28
Regioni500 – 523DisorderedSequence analysisAdd BLAST24
Regioni891 – 940DisorderedSequence analysisAdd BLAST50
Regioni1033 – 1056DisorderedSequence analysisAdd BLAST24
Regioni1133 – 1168DisorderedSequence analysisAdd BLAST36
Regioni1184 – 1219DisorderedSequence analysisAdd BLAST36
Regioni1455 – 1482DisorderedSequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi891 – 906PolarSequence analysisAdd BLAST16
Compositional biasi1033 – 1053PolyampholyteSequence analysisAdd BLAST21
Compositional biasi1184 – 1205PolyampholyteSequence analysisAdd BLAST22
Compositional biasi1455 – 1474PolarSequence analysisAdd BLAST20

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1968, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153469

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002810_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		H9GS46

Database of Orthologous Groups

More...OrthoDBi		162624at2759

TreeFam database of animal gene trees

More...TreeFami		TF329112

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593, AAA+_ATPase
IPR003959, ATPase_AAA_core
IPR027417, P-loop_NTPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00004, AAA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382, AAA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9GS46-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVAASSADG DVQPCKKQKE DDPSMKSITK YFPPLGKNVH SVASPPKPNN 
        60         70         80         90        100
IMDYFKKSSP TNEKIVSPVT EKESKTTCLS LETSSKSSSR LKRRGKRCRL 
       110        120        130        140        150
MNTLNDVKTS DFLIEFNSDN NIDILSSEEK DSKTSPISPS IPTLLDLTNT 
       160        170        180        190        200
EETFNACSKN PSNIFSFKNQ ERKIKTEGDV IKSNVKTSKK RKHKDESDSS 
       210        220        230        240        250
ECFVTETQQK DLSKIADDKQ VASIRECDKS PLVKIQAHDT SAHETPHLND 
       260        270        280        290        300
NTVTVSFEDF LKSQGENEDH IPKTQTSDDP IACDEAVSCQ DVQELSLKKV 
       310        320        330        340        350
TVLAQIHSVP PKSLSSQKIA SIFLKQKSKK AKRQSTLPAS EGEGTEQMTL 
       360        370        380        390        400
KRKSNVVIGE EELELAILET SGSEGVKSKC TAEERYQFMK AFKQPESEAI 
       410        420        430        440        450
KTAAKKGTSK QKEVEETSSK HKLEMEECED AFNKRLENES SVFNANINFH 
       460        470        480        490        500
DKDSRSDIHR VKANKLRRKN KVLKTKGEVL DMNSNQKSEA CSQIKAGTSI 
       510        520        530        540        550
DAQNKLPQKN NGLRRSPRQK KDTNSILCTP EKAGIAEALT ENTSPAIPLQ 
       560        570        580        590        600
ASTPKTNNDM FDKSDLYKAE VITEPFDSKS PIRMKFTRIS VTERCMQQSI 
       610        620        630        640        650
KMNTTSSNIT KAKKLVEKAK VLQHHRKTRT VEDILHTPLR RSTRQQAIAD 
       660        670        680        690        700
RKRSHNLEDS VIDLDLCTNI TSTVVGSVDR KKKHRNLNDV LGKKARNVKA 
       710        720        730        740        750
TKKSSGKEKM SSLVRKKIKR PMDETIAILD ESSEDDSENS QDDKQFRAKR 
       760        770        780        790        800
NFLMSGLPES LKRQIAKKAA ALEACSLANS CFQTVVHVQQ KDEGRLMWRL 
       810        820        830        840        850
ALPSCPLLTN LREVYLDVAD VTKLTFSLGD FSILNTQPHN TKFPTALLSG 
       860        870        880        890        900
WRPALTDAQK SYLLEEIQFF NTHFPVKQFF DLMMKKQAAS DNNKQVNKCE 
       910        920        930        940        950
AVSSDTNIKS DNRREAKRKR KTEDRKSKRR KPIEKTEADL PNNVCKVSNV 
       960        970        980        990       1000
KQAGMENTIH IIDTHEESEI ITIEDSDSGS EIRPASDFTH EDTLWTEKYQ 
      1010       1020       1030       1040       1050
PQNSSELIGN TVAIKKLHRW LCEWKRRVDW EENRTQKEED GTHQESSDIV 
      1060       1070       1080       1090       1100
DFQDDRSDSE DEAVLCNTML LIGPPGIGKT AAVYACAQEL GFKIFEVNAS 
      1110       1120       1130       1140       1150
CQRSGRQILS HLKEATQSHQ VDKQGVHAHK AAFFNSYSTS KSPKKGSPRK 
      1160       1170       1180       1190       1200
EWSPRKLTIS PRKGGLKQGL APRTLANYFK ISSKSQNKEE KKAQGDNKEN 
      1210       1220       1230       1240       1250
KKILPGENTQ VKSVKREAKE EESSKKCATS LILFEEVDII FDEDVGFLNA 
      1260       1270       1280       1290       1300
IKTFMTTTKR PVILTTNDPS FSLIFDGCFE EITFTAPSLI NVASYLQVLC 
      1310       1320       1330       1340       1350
LAENLRTDIK DFTALLTSNN CDIRQSVLHL QFWVKSGGGY LKEKRMATHG 
      1360       1370       1380       1390       1400
KEASDTEQGA SVKEPTKIPK YDTGCIENLL GLTNIFLPSE DLLSFLKHEI 
      1410       1420       1430       1440       1450
TTKEEWNKLI HLLTEFQRKD IDFIYNNLEN ILPLPVNIFP ETMLVPPLSC 
      1460       1470       1480       1490       1500
ENFTKNTSNN RPIDSQSLGE TSPVEKAKQT KRRKKNVILD DSDLFESELN 
      1510       1520       1530       1540       1550
YSGFITVPSD TTTSCLEENP KFKSAAALND QTIAKPKGSA LTFQCLGSLT 
      1560       1570       1580       1590       1600
EFVDNMSFSD CCFSRRTQES TQSCKYEEFI WTKGKIKNGL SDEFSLEDTD 
      1610       1620       1630       1640       1650
WWRSQSSIEL KATMEALNFN KCLKNVSKIM ENALNTARTC GKNDSEELSL 
      1660       1670       1680       1690       1700
HFSKDQSNLY FGQSAANSRI HDNAQKRLEL IKTVFSGRTQ FNFSNRQASV 
      1710       1720       1730       1740 
MEYLPTLRTI CKSEKQKEQG KTKRRFLHYL EGIHLTKEIL TSLTADFP
Length:1,748
Mass (Da):197,215
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7A2079BE41E19B8A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AAWZ02011875 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_008112592.1, XM_008114385.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSACAT00000025082; ENSACAP00000019218; ENSACAG00000009606

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100551815

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		acs:100551815

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02011875 Genomic DNA No translation available.
RefSeqiXP_008112592.1, XM_008114385.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000019218

Genome annotation databases

EnsembliENSACAT00000025082; ENSACAP00000019218; ENSACAG00000009606
GeneIDi100551815
KEGGiacs:100551815

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79915

Phylogenomic databases

eggNOGiKOG1968, Eukaryota
GeneTreeiENSGT00940000153469
HOGENOMiCLU_002810_0_0_1
InParanoidiH9GS46
OrthoDBi162624at2759
TreeFamiTF329112

Gene expression databases

BgeeiENSACAG00000009606, Expressed in forelimb bud and 14 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR003959, ATPase_AAA_core
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00004, AAA, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9GS46_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9GS46
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: June 26, 2013
Last modified: October 7, 2020
This is version 47 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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