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Entry version 47 (07 Oct 2020)
Sequence version 2 (26 Jun 2013)
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Protein

AAA domain-containing protein

Gene

ATAD5

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AAA domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATAD5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000009606, Expressed in forelimb bud and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000019218

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1065 – 1289AAAInterPro annotationAdd BLAST225

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 28DisorderedSequence analysisAdd BLAST28
Regioni500 – 523DisorderedSequence analysisAdd BLAST24
Regioni891 – 940DisorderedSequence analysisAdd BLAST50
Regioni1033 – 1056DisorderedSequence analysisAdd BLAST24
Regioni1133 – 1168DisorderedSequence analysisAdd BLAST36
Regioni1184 – 1219DisorderedSequence analysisAdd BLAST36
Regioni1455 – 1482DisorderedSequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi891 – 906PolarSequence analysisAdd BLAST16
Compositional biasi1033 – 1053PolyampholyteSequence analysisAdd BLAST21
Compositional biasi1184 – 1205PolyampholyteSequence analysisAdd BLAST22
Compositional biasi1455 – 1474PolarSequence analysisAdd BLAST20

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1968, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153469

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002810_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H9GS46

Database of Orthologous Groups

More...
OrthoDBi
162624at2759

TreeFam database of animal gene trees

More...
TreeFami
TF329112

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR003959, ATPase_AAA_core
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00004, AAA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9GS46-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVAASSADG DVQPCKKQKE DDPSMKSITK YFPPLGKNVH SVASPPKPNN
60 70 80 90 100
IMDYFKKSSP TNEKIVSPVT EKESKTTCLS LETSSKSSSR LKRRGKRCRL
110 120 130 140 150
MNTLNDVKTS DFLIEFNSDN NIDILSSEEK DSKTSPISPS IPTLLDLTNT
160 170 180 190 200
EETFNACSKN PSNIFSFKNQ ERKIKTEGDV IKSNVKTSKK RKHKDESDSS
210 220 230 240 250
ECFVTETQQK DLSKIADDKQ VASIRECDKS PLVKIQAHDT SAHETPHLND
260 270 280 290 300
NTVTVSFEDF LKSQGENEDH IPKTQTSDDP IACDEAVSCQ DVQELSLKKV
310 320 330 340 350
TVLAQIHSVP PKSLSSQKIA SIFLKQKSKK AKRQSTLPAS EGEGTEQMTL
360 370 380 390 400
KRKSNVVIGE EELELAILET SGSEGVKSKC TAEERYQFMK AFKQPESEAI
410 420 430 440 450
KTAAKKGTSK QKEVEETSSK HKLEMEECED AFNKRLENES SVFNANINFH
460 470 480 490 500
DKDSRSDIHR VKANKLRRKN KVLKTKGEVL DMNSNQKSEA CSQIKAGTSI
510 520 530 540 550
DAQNKLPQKN NGLRRSPRQK KDTNSILCTP EKAGIAEALT ENTSPAIPLQ
560 570 580 590 600
ASTPKTNNDM FDKSDLYKAE VITEPFDSKS PIRMKFTRIS VTERCMQQSI
610 620 630 640 650
KMNTTSSNIT KAKKLVEKAK VLQHHRKTRT VEDILHTPLR RSTRQQAIAD
660 670 680 690 700
RKRSHNLEDS VIDLDLCTNI TSTVVGSVDR KKKHRNLNDV LGKKARNVKA
710 720 730 740 750
TKKSSGKEKM SSLVRKKIKR PMDETIAILD ESSEDDSENS QDDKQFRAKR
760 770 780 790 800
NFLMSGLPES LKRQIAKKAA ALEACSLANS CFQTVVHVQQ KDEGRLMWRL
810 820 830 840 850
ALPSCPLLTN LREVYLDVAD VTKLTFSLGD FSILNTQPHN TKFPTALLSG
860 870 880 890 900
WRPALTDAQK SYLLEEIQFF NTHFPVKQFF DLMMKKQAAS DNNKQVNKCE
910 920 930 940 950
AVSSDTNIKS DNRREAKRKR KTEDRKSKRR KPIEKTEADL PNNVCKVSNV
960 970 980 990 1000
KQAGMENTIH IIDTHEESEI ITIEDSDSGS EIRPASDFTH EDTLWTEKYQ
1010 1020 1030 1040 1050
PQNSSELIGN TVAIKKLHRW LCEWKRRVDW EENRTQKEED GTHQESSDIV
1060 1070 1080 1090 1100
DFQDDRSDSE DEAVLCNTML LIGPPGIGKT AAVYACAQEL GFKIFEVNAS
1110 1120 1130 1140 1150
CQRSGRQILS HLKEATQSHQ VDKQGVHAHK AAFFNSYSTS KSPKKGSPRK
1160 1170 1180 1190 1200
EWSPRKLTIS PRKGGLKQGL APRTLANYFK ISSKSQNKEE KKAQGDNKEN
1210 1220 1230 1240 1250
KKILPGENTQ VKSVKREAKE EESSKKCATS LILFEEVDII FDEDVGFLNA
1260 1270 1280 1290 1300
IKTFMTTTKR PVILTTNDPS FSLIFDGCFE EITFTAPSLI NVASYLQVLC
1310 1320 1330 1340 1350
LAENLRTDIK DFTALLTSNN CDIRQSVLHL QFWVKSGGGY LKEKRMATHG
1360 1370 1380 1390 1400
KEASDTEQGA SVKEPTKIPK YDTGCIENLL GLTNIFLPSE DLLSFLKHEI
1410 1420 1430 1440 1450
TTKEEWNKLI HLLTEFQRKD IDFIYNNLEN ILPLPVNIFP ETMLVPPLSC
1460 1470 1480 1490 1500
ENFTKNTSNN RPIDSQSLGE TSPVEKAKQT KRRKKNVILD DSDLFESELN
1510 1520 1530 1540 1550
YSGFITVPSD TTTSCLEENP KFKSAAALND QTIAKPKGSA LTFQCLGSLT
1560 1570 1580 1590 1600
EFVDNMSFSD CCFSRRTQES TQSCKYEEFI WTKGKIKNGL SDEFSLEDTD
1610 1620 1630 1640 1650
WWRSQSSIEL KATMEALNFN KCLKNVSKIM ENALNTARTC GKNDSEELSL
1660 1670 1680 1690 1700
HFSKDQSNLY FGQSAANSRI HDNAQKRLEL IKTVFSGRTQ FNFSNRQASV
1710 1720 1730 1740
MEYLPTLRTI CKSEKQKEQG KTKRRFLHYL EGIHLTKEIL TSLTADFP
Length:1,748
Mass (Da):197,215
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7A2079BE41E19B8A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAWZ02011875 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_008112592.1, XM_008114385.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000025082; ENSACAP00000019218; ENSACAG00000009606

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100551815

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
acs:100551815

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02011875 Genomic DNA No translation available.
RefSeqiXP_008112592.1, XM_008114385.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000019218

Genome annotation databases

EnsembliENSACAT00000025082; ENSACAP00000019218; ENSACAG00000009606
GeneIDi100551815
KEGGiacs:100551815

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79915

Phylogenomic databases

eggNOGiKOG1968, Eukaryota
GeneTreeiENSGT00940000153469
HOGENOMiCLU_002810_0_0_1
InParanoidiH9GS46
OrthoDBi162624at2759
TreeFamiTF329112

Gene expression databases

BgeeiENSACAG00000009606, Expressed in forelimb bud and 14 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR003959, ATPase_AAA_core
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00004, AAA, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9GS46_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9GS46
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: June 26, 2013
Last modified: October 7, 2020
This is version 47 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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