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Entry version 43 (02 Jun 2021)
Sequence version 2 (26 Jun 2013)
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Protein

Spatacsin_C domain-containing protein

Gene

SPG11

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spatacsin_C domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPG11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000013808, Expressed in skeletal muscle tissue and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000013687

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2064 – 2345Spatacsin_CInterPro annotationAdd BLAST282

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1894 – 1928DisorderedSequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1895 – 1917Basic and acidic residuesSequence analysisAdd BLAST23

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1884, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016791

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001081_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H9GKG8

Identification of Orthologs from Complete Genome Data

More...
OMAi
SYCEDIY

TreeFam database of animal gene trees

More...
TreeFami
TF325171

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028103, Spatacsin
IPR028107, Spatacsin_C_dom

The PANTHER Classification System

More...
PANTHERi
PTHR13650, PTHR13650, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14649, Spatacsin_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9GKG8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPLRVLLL PSRDFPDEKT SRAKLSRGAR EVLASVTRTG LRVSGEEAAL
60 70 80 90 100
LPGPWEDFLW ESVEEEDPTA EGPRLLALSK SHDLFIYEVT LEAGKCEAVL
110 120 130 140 150
WESLPEDRLT RLVASKDKSF SSLSSLRLLS FKNGKALVLL NKIILARLSF
160 170 180 190 200
PVGEPAAITL KDCFVLHLSP QAAERIVDVT LCRGIVFLLD ESGWIYFFDA
210 220 230 240 250
TDGTYLAYVD ISLYLSEGQE EENADTLPPL IRLNVSHDLS VAVIVSCCHS
260 270 280 290 300
VASVDLNVYF RQYPDHLLCK RNTDSSPIKP WEGTDEDDLR SSEYSMAFVQ
310 320 330 340 350
GAFRTDRSWK AHLLSLRDTT EQCYSPYLLP ESSLLWYQSF LHPEQPECAT
360 370 380 390 400
CELSETSLLQ DAAYILSDSR GKGMTTRNQV DRQWKNIYSG DPEDGLELEC
410 420 430 440 450
KSVTGFSALF TISSESEGLT VVLWDLETRE MVRSHVGKNA CFVECGREEQ
460 470 480 490 500
LCLILSEPGL SLFLFGLTQE EFLNRLIIHG SAGTMDSLCR LNGWGRCSIP
510 520 530 540 550
IHTLEAGLEN RQLDTVNFFL KNKENLFSPP PSCSAQDQPA SVGSEMYLKS
560 570 580 590 600
MKELRPALDL LCVAIQESDL EAQSKHFSEQ LLNLTLSFLN KQLCEIFVHR
610 620 630 640 650
EELDDNLDRC VDMLTSYITR LRTFMMKFPP KTTSAVTLLC DPEEDVPPIE
660 670 680 690 700
QSHAWEALDT ESIVAEAILN NKLPEAQTFF RLTRNPAQQL KELTRIGLDL
710 720 730 740 750
VYKSLLKNDI KEASRLLRNM GFNVAEQLHK ICFYVTDQHV RDYLVERLQE
760 770 780 790 800
KKVFSDAEKE MIDFVHQVEG VYSGTVQENR ESPAQSRHWR RDQDLSIHTD
810 820 830 840 850
ALDTLLTCNE DSARKGEHKL MLNWAQWWDQ VAQEMILLPK RSLEENAELK
860 870 880 890 900
SCNPEVLWMY LSSWQDWANI SSWMAESQQQ ERSTKWPQLT IETINQSTLC
910 920 930 940 950
SPYMQNEILD NLARNGTFVP TELDSFECLL QRLTLVGGVM QNPHPVPRYT
960 970 980 990 1000
ALDGRDFHGR FILYCLDHGL DHLLYTYLDF YSLYPSNCPV LNDKALHETH
1010 1020 1030 1040 1050
PWFEFLVQCR SIASSPEDAA LIFQASLANA QILIPSNQAS VSTMLLEGRT
1060 1070 1080 1090 1100
LLALATTMYS PGGIDQVVQN GDRGEKVDTQ LFRMALAPYP KLRAALFPQC
1110 1120 1130 1140 1150
AAHGLLPSDI SLYHLLQSLA PFDPAKLFGW QSTNALAIPD IGSDLPHFSC
1160 1170 1180 1190 1200
PALVNKYAVI ERLDFSYYLC HERPSFAFGT LIVQQLAKSK TPKQLIQQAG
1210 1220 1230 1240 1250
AEAYALALSS FYVPSVAASC ACFLELLGLE SLKLRVDVKA AGVILSFMSR
1260 1270 1280 1290 1300
REEPQHNSIR QSLVEKLAEL ASGQKTAAEE LLLCLEEAVW DKIEHQEIEN
1310 1320 1330 1340 1350
FSSGTLCLGK ILLWRLLNRG WMTISLGYCE VCWKLGNVFI YSTVESHLSN
1360 1370 1380 1390 1400
INGPAECWIS EYSLLIIQHF RLSNVLPARL CWISETLTAS EQHALSATET
1410 1420 1430 1440 1450
LDLSHWVIFP ADNLTEALAH RLYSLYLLKS HSHITVVSIY IKTTANANPS
1460 1470 1480 1490 1500
TSKKGYISHL LKGYSWSVLS YIFIKIRCLG LYSGRLIPNF GCFCIKDSPL
1510 1520 1530 1540 1550
KTVLEVYELC MEYKNYSEAQ SKLLAFQASL SELRGAPLGP EAPLPVPWLE
1560 1570 1580 1590 1600
SQASFLLGLM LQQCRTEYEL GKLLRLFADA DTALPHDSGP NMRKLSALSD
1610 1620 1630 1640 1650
VLCGSPVSMD RALLCSYSPE NFQKECRRIL EQLQERSAFS VARSVAELAG
1660 1670 1680 1690 1700
LPVDNVVIQE AFQSIEHLKQ IGHWPQERTR AEFWKKCHEN FVQNAVSTVA
1710 1720 1730 1740 1750
ASDFFLAQAD RVPESSESEQ GCVLLERQLL LTLAGHWWAR SDPIPLDGLE
1760 1770 1780 1790 1800
RIEKEIWLCC VSQEALRRTV GQAPDDTFSP SVSAAGEPSF VSLAKEFSFS
1810 1820 1830 1840 1850
KMAALNTPAY LRLEGLPLPG ASPAQLLGEE GQALGFLIGR LLDEGSVHEA
1860 1870 1880 1890 1900
SRVCRYFGFY SRDVAIVLHC RALASKEGPQ NWFHPEIQEI LGALEKGGSK
1910 1920 1930 1940 1950
EREEKEEPAR KSRQEGSTDQ EQGASSAEGD AIAGGLQALT AESVHGRNYC
1960 1970 1980 1990 2000
RQVQCLYELA KELGCSFSDI SAHDPERLLR MILSSPQPDR CRRAEAFISA
2010 2020 2030 2040 2050
QGLKPEDVAA LVAEEVLREL LAPSLQKGTG QKHVLNPAEE SEAFLQLAKL
2060 2070 2080 2090 2100
CPDRTLVGMK LLDKIALVPP GELACTTELL ILAHNCFSLT CHMEGITRVL
2110 2120 2130 2140 2150
QAARLLTEEH LAPSEEYGLV VRLLTGIGRY NEMTYIFDLL HDKHHFEVLM
2160 2170 2180 2190 2200
RKKLDPSGTL KTALLDYIKR CRPGDSEKHN MIALCFSMCR EIGENHEAAA
2210 2220 2230 2240 2250
HVQLKLIESQ PWEECLQNVP ALKKLLMKAL TLFIDAAESY SKDFCVRQSL
2260 2270 2280 2290 2300
RCSRLTKLIT LQLHFLNTGQ STKLINLSRK SLLECVMALP RFYQAAIVAE
2310 2320 2330 2340 2350
AYDFVPDWAE VLCQHVILKG DFNYLAEYKQ RGLLKASTIE EIACKSKQHP
2360 2370 2380 2390 2400
GSEAALRNLK KLLTYCDDIY IYYKLAYDNQ FYDVVNMLLK DAQTGCCLND

LLAN
Length:2,404
Mass (Da):270,208
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB1449D30947C8990
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAWZ02031400 Genomic DNA No translation available.
AAWZ02031401 Genomic DNA No translation available.
AAWZ02031402 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000013968; ENSACAP00000013687; ENSACAG00000013808

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02031400 Genomic DNA No translation available.
AAWZ02031401 Genomic DNA No translation available.
AAWZ02031402 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000013687

Genome annotation databases

EnsembliENSACAT00000013968; ENSACAP00000013687; ENSACAG00000013808

Phylogenomic databases

eggNOGiKOG1884, Eukaryota
GeneTreeiENSGT00390000016791
HOGENOMiCLU_001081_0_0_1
InParanoidiH9GKG8
OMAiSYCEDIY
TreeFamiTF325171

Gene expression databases

BgeeiENSACAG00000013808, Expressed in skeletal muscle tissue and 14 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR028103, Spatacsin
IPR028107, Spatacsin_C_dom
PANTHERiPTHR13650, PTHR13650, 1 hit
PfamiView protein in Pfam
PF14649, Spatacsin_C, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9GKG8_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9GKG8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: June 26, 2013
Last modified: June 2, 2021
This is version 43 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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