UniProtKB - H9GJV0 (H9GJV0_ANOCA)
Protein
Chondroitinsulfatase
Gene
GALNS
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Catalytic activityi
- Hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate.ARBA annotation EC:3.1.6.4
Cofactori
Ca2+ARBA annotation
GO - Molecular functioni
- arylsulfatase activity Source: GO_Central
- N-acetylgalactosamine-6-sulfatase activity Source: UniProtKB-EC
Keywordsi
Molecular function | HydrolaseARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: ChondroitinsulfataseARBA annotation (EC:3.1.6.4ARBA annotation)Alternative name(s): Galactose-6-sulfate sulfataseARBA annotation N-acetylgalactosamine-6-sulfataseARBA annotation N-acetylgalactosamine-6-sulfate sulfataseARBA annotation |
Gene namesi | Name:GALNSImported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Keywords - Cellular componenti
LysosomeARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_5003619456 | 22 – 520 | ChondroitinsulfataseSequence analysisAdd BLAST | 499 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 76 | 3-oxoalanine (Cys)UniRule annotation | 1 |
Post-translational modificationi
The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.UniRule annotation
Expressioni
Gene expression databases
Bgeei | ENSACAG00000013289, Expressed in kidney and 13 other tissues |
Interactioni
Subunit structurei
Homodimer.
ARBA annotationProtein-protein interaction databases
STRINGi | 28377.ENSACAP00000013121 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 352 | SulfataseInterPro annotationAdd BLAST | 325 |
Sequence similaritiesi
Belongs to the sulfatase family.ARBA annotation
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
eggNOGi | KOG3867, Eukaryota |
GeneTreei | ENSGT00940000157787 |
HOGENOMi | CLU_006332_13_5_1 |
InParanoidi | H9GJV0 |
OrthoDBi | 515367at2759 |
TreeFami | TF314186 |
Family and domain databases
CDDi | cd16157, GALNS, 1 hit |
Gene3Di | 3.40.720.10, 1 hit |
InterProi | View protein in InterPro IPR017850, Alkaline_phosphatase_core_sf IPR035626, GALNS IPR024607, Sulfatase_CS IPR000917, Sulfatase_N |
Pfami | View protein in Pfam PF00884, Sulfatase, 1 hit |
SUPFAMi | SSF53649, SSF53649, 1 hit |
PROSITEi | View protein in PROSITE PS00523, SULFATASE_1, 1 hit |
i Sequence
Sequence statusi: Complete.
H9GJV0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATILLVLFC GLVDFWSLAE GKSNATSPNL VLLLMDDMGW GDLGVFGQPS
60 70 80 90 100
KETPHLDQMA AEGMLFPSFY TANPLCSPSR AALLTGRLPI RNGFYTTNAH
110 120 130 140 150
ARNAYTPQDI TGGIPDSELL LPELLKKAGY ANKIVGKWHL GHQPQFHPLR
160 170 180 190 200
HGFDEWFGSP NCHFGPYDNK AAPNIPVYRD WEMIGRYYED IKINHKTGES
210 220 230 240 250
NLTQMYLQEA LDFMSSQQAK QQPFFLYWAI DATHAPVYAS RAFLGSSQRG
260 270 280 290 300
RYGDAVREID DSVGKILSHL RKLGISEDTF VFFTSDNGAA LVSAPEQAGS
310 320 330 340 350
NGPFLCGKQT TFEGGMREPA IAWWPGHIPA GQVSHQLGSV MDLFATSLAL
360 370 380 390 400
AGLPPPGDRE IDGIDLSPVV LQGKLIDRPI FYYRGNEMMA VRVGLYKAHY
410 420 430 440 450
WTWSNSWEEF GQGIDFCPGQ NVSGVTSHDQ EEHSKLPLLF HLGKDPGERF
460 470 480 490 500
PISFSSAEYQ DVMGRISPVV EQHKETMLPG QPQLNVCDKA VMNWAPPGCE
510 520
KIGKCLDPPQ PDPQKCFWPH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02033999 Genomic DNA No translation available. |
RefSeqi | XP_008121785.1, XM_008123578.2 |
Genome annotation databases
Ensembli | ENSACAT00000013381; ENSACAP00000013121; ENSACAG00000013289 |
GeneIDi | 100556157 |
KEGGi | acs:100556157 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02033999 Genomic DNA No translation available. |
RefSeqi | XP_008121785.1, XM_008123578.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000013121 |
Genome annotation databases
Ensembli | ENSACAT00000013381; ENSACAP00000013121; ENSACAG00000013289 |
GeneIDi | 100556157 |
KEGGi | acs:100556157 |
Organism-specific databases
CTDi | 2588 |
Phylogenomic databases
eggNOGi | KOG3867, Eukaryota |
GeneTreei | ENSGT00940000157787 |
HOGENOMi | CLU_006332_13_5_1 |
InParanoidi | H9GJV0 |
OrthoDBi | 515367at2759 |
TreeFami | TF314186 |
Gene expression databases
Bgeei | ENSACAG00000013289, Expressed in kidney and 13 other tissues |
Family and domain databases
CDDi | cd16157, GALNS, 1 hit |
Gene3Di | 3.40.720.10, 1 hit |
InterProi | View protein in InterPro IPR017850, Alkaline_phosphatase_core_sf IPR035626, GALNS IPR024607, Sulfatase_CS IPR000917, Sulfatase_N |
Pfami | View protein in Pfam PF00884, Sulfatase, 1 hit |
SUPFAMi | SSF53649, SSF53649, 1 hit |
PROSITEi | View protein in PROSITE PS00523, SULFATASE_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H9GJV0_ANOCA | |
Accessioni | H9GJV0Primary (citable) accession number: H9GJV0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | June 26, 2013 | |
Last modified: | December 2, 2020 | |
This is version 53 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |