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Entry version 49 (07 Apr 2021)
Sequence version 1 (16 May 2012)
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Protein

Mediator of RNA polymerase II transcription subunit 13

Gene

MED13

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivatorUniRule annotation, RepressorUniRule annotationARBA annotation
Biological processTranscription, Transcription regulationUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 13UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MED13Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1149 – 1168HelicalSequence analysisAdd BLAST20
Transmembranei1180 – 1206HelicalSequence analysisAdd BLAST27
Transmembranei1232 – 1251HelicalSequence analysisAdd BLAST20
Transmembranei1263 – 1290HelicalSequence analysisAdd BLAST28
Transmembranei1313 – 1330HelicalSequence analysisAdd BLAST18
Transmembranei1342 – 1369HelicalSequence analysisAdd BLAST28
Transmembranei1456 – 1474HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane, NucleusUniRule annotationARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000013077, Expressed in embryonic post-anal tail and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Mediator complex.

UniRule annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000012887

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini13 – 255Med13_NInterPro annotationAdd BLAST243
Domaini1501 – 1570MID_MedPIWIInterPro annotationAdd BLAST70
Domaini1606 – 2005Med13_CInterPro annotationAdd BLAST400

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni445 – 486DisorderedSequence analysisAdd BLAST42
Regioni532 – 573DisorderedSequence analysisAdd BLAST42
Regioni703 – 752DisorderedSequence analysisAdd BLAST50
Regioni807 – 834DisorderedSequence analysisAdd BLAST28
Regioni1860 – 1887DisorderedSequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi445 – 466PolarSequence analysisAdd BLAST22
Compositional biasi467 – 484PolyampholyteSequence analysisAdd BLAST18
Compositional biasi711 – 740PolyampholyteSequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Mediator complex subunit 13 family.UniRule annotationARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3600, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013680

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000508_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H9GJM3

Identification of Orthologs from Complete Genome Data

More...
OMAi
XARRKKG

TreeFam database of animal gene trees

More...
TreeFami
TF316867

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009401, Med13_C
IPR021643, Mediator_Med13_N
IPR041285, MID_MedPIWI

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06333, Med13_C, 1 hit
PF11597, Med13_N, 1 hit
PF18296, MID_MedPIWI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9GJM3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VKMSSCFVPN GASLEDCHSN LFCLADLTGI KWKRYVWEGP TSAPILFPVT
60 70 80 90 100
EEDPILSSYS RCLKADVLSV WRRDQRPGRR ELMIFWWGDD PNFADLIHHE
110 120 130 140 150
LADEEDGVWE NGLSYECRTL LFKAIHNLVE RCLMNRNFVR IGKWFVKPYE
160 170 180 190 200
KDEKPVNKSE HLSCSFTFFL HGDSNVCTSV EINQHQPVYF VSEEHLTLAQ
210 220 230 240 250
QSNSPFQVIL SPFGLNGTLT GQSFKLSDSA TKKLIGEWKQ FYPITSNLKE
260 270 280 290 300
GLEEKQEEMD WEDDSLAAVE VLVAGVRMVY PACFVLVPQT DIPTPSAPGS
310 320 330 340 350
SNCLGVHQVP ASTRDPAMSS VTLTPPTSPE DVQTVDARSA QKWVKLSSVS
360 370 380 390 400
DAFSSDSTSH HGGRIPRKLA NQVVDRVWQE CNMNRALTKR KYSATSNGLC
410 420 430 440 450
EEETVDKIAF WDFVEATQRT NCICSRYTSF RYSCRIVVQK PTSISQKGLQ
460 470 480 490 500
QGTVPPVGQQ QQAVAKHKAN EKPEKGDKPQ KRPLTPFHHR VSISDDVAME
510 520 530 540 550
ADSASQRLVI TASDSQVRFS NLRTSDVAKT PQMHGTEMAT SPQPPPLSPH
560 570 580 590 600
PCDVADEGAT KTPSTPQNQH FYHMPTPDPL VPPKAMEDRI EGLSQTFPAP
610 620 630 640 650
FPEVIEPTMY VGTAVNLEEE DTDSTWKFYK VPKRKDMDFL PPQLPSEKFR
660 670 680 690 700
DSYPLKPRLF LLYRLMVQCR KPLKVSDELV QQYQSKNQYL AAIVADQEPE
710 720 730 740 750
MDPYAFVDGD EDFPFPDKKD RQNSEREVGK KHKDNNNKKT SNLTDDGAPN
760 770 780 790 800
VGEDAMSLFS PSVKQALDAQ RIPPHNRTAS TSLFHENDLV VSYTDLDNLF
810 820 830 840 850
NSDEDELTAV SEPSVPGSKR MLNGTDDKSN CKESKAGNLD PLSCIKTGTA
860 870 880 890 900
DLHKMYPTPP SLEQHIMGFS PMNMNNKEYG SMDTTPGGTV LDGNGTTAGI
910 920 930 940 950
QFRIEVDEGF CSPKPSEIKD YSYVYKPENI QPFVGCSMFA PLKTLPSQCL
960 970 980 990 1000
PAIKLPEECI YRQSWTVGKL ELLPPGPTMP FIKEGYVYVV WIFTTYNIYR
1010 1020 1030 1040 1050
QTQRQFNIFQ LHEGRLDSGH RTCALVTPES LMVLLPHSFP HAAGSFYCGL
1060 1070 1080 1090 1100
SNIYSESEEY ISRRDSKMKS CRLNNTFFSH TSDMSIVSVY PSFWIKSLRP
1110 1120 1130 1140 1150
DQSVFCWKFL LLTSCATDQC DIFLLSKIIW LHYLQKQVSH NTNKVFCCIG
1160 1170 1180 1190 1200
SHAGHFPNYY IIVIIIIIET QQDESTRDTL LAVVLDHTSD TSPVIIVLLL
1210 1220 1230 1240 1250
LLLLLLETQQ DESTADTLLA VVSDHTSDTS QVIILLLLLL LLLLLLLLLL
1260 1270 1280 1290 1300
FETQQDESTA DTLLAVVLDH TSDTSQVIIL LLLLLLLLLF ETQEDKSTAD
1310 1320 1330 1340 1350
TLLAVVLDHT SDTSQVIILL LLLLLLLLLF ETQEDKSTAD TLLAVVLDHT
1360 1370 1380 1390 1400
SDTSQVIILL LLLLLLLLFE TQQDKSTADT LLAVVLTLDK RDSTVFDFAV
1410 1420 1430 1440 1450
SHPESPSGEM KMGYNIIITV ESHLSKPGLS KPFLYNYYIT LLRIELLFLS
1460 1470 1480 1490 1500
NLLYNMMFWC LICLIDFSLI PPYYPRYSLI QASAGPFSLD KQLQLPNDKI
1510 1520 1530 1540 1550
NPTNSQIWAY RVSSIMLKLK EVISFLSFSS RSSQLVPCQY LLQPVKNEDR
1560 1570 1580 1590 1600
HIYTQHLKSL AFSAFTQCRR PLPTSTNVKT LTGFGPGLAM EMALKSPERP
1610 1620 1630 1640 1650
ECIKLYAPPF ILAPVKDKQT ELGETFGEAG QKYNVLFVGY CLSHDQRWLL
1660 1670 1680 1690 1700
ASCTDMYGEL LETCIINIDV PNRARRKKGS ARRLGLQKLW EWCLGLVQMS
1710 1720 1730 1740 1750
SVPWRVVIGR LGRIGHGELK DWSCLLSRRN LQSLSKRLKD MCRMCGISAA
1760 1770 1780 1790 1800
DSPSILSACL VAMEPQGSFV IMPDSVSTGS VFGRSTTLNM QTSQLNTPQD
1810 1820 1830 1840 1850
TSCTHILVFP TSASVQVASS TYTTETGLEL AFNTNNVGIF ELLGTADDLD
1860 1870 1880 1890 1900
PDIINILPAS PTGSPVHSPS SHFTHGGDMG KGQGTDRLLS TESHDEVTNI
1910 1920 1930 1940 1950
LQQPLALGYF VSTAKAGPLP DWFWSACPQA QNQCPLFLKA SLHLHVPSVQ
1960 1970 1980 1990 2000
SDELLHSKHS HPLDSNQTSD VLRFVLEQYN ALSWLTCDPA TQDRRSCLPV
2010
HFVVLNQLYN FIMNML
Length:2,016
Mass (Da):226,049
Last modified:May 16, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF1FEAE7EF06B07D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAWZ02028577 Genomic DNA No translation available.
AAWZ02028578 Genomic DNA No translation available.
AAWZ02028579 Genomic DNA No translation available.
AAWZ02028580 Genomic DNA No translation available.
AAWZ02028581 Genomic DNA No translation available.
AAWZ02028582 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000013145; ENSACAP00000012887; ENSACAG00000013077

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02028577 Genomic DNA No translation available.
AAWZ02028578 Genomic DNA No translation available.
AAWZ02028579 Genomic DNA No translation available.
AAWZ02028580 Genomic DNA No translation available.
AAWZ02028581 Genomic DNA No translation available.
AAWZ02028582 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000012887

Genome annotation databases

EnsembliENSACAT00000013145; ENSACAP00000012887; ENSACAG00000013077

Phylogenomic databases

eggNOGiKOG3600, Eukaryota
GeneTreeiENSGT00390000013680
HOGENOMiCLU_000508_0_0_1
InParanoidiH9GJM3
OMAiXARRKKG
TreeFamiTF316867

Gene expression databases

BgeeiENSACAG00000013077, Expressed in embryonic post-anal tail and 14 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR009401, Med13_C
IPR021643, Mediator_Med13_N
IPR041285, MID_MedPIWI
PfamiView protein in Pfam
PF06333, Med13_C, 1 hit
PF11597, Med13_N, 1 hit
PF18296, MID_MedPIWI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9GJM3_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9GJM3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: April 7, 2021
This is version 49 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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