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UniProtKB - H9GJM2 (H9GJM2_ANOCA)

Entry version 55 (02 Dec 2020)
Sequence version 2 (26 Jun 2013)
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Protein

USP domain-containing protein

Gene

USP42

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Protein family/group databases

MEROPS protease database

More...MEROPSi		C19.048

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
USP domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:USP42Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSACAG00000013073, Expressed in heart and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		28377.ENSACAP00000012882

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini111 – 412USPInterPro annotationAdd BLAST302

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 40DisorderedSequence analysisAdd BLAST40
Regioni447 – 520DisorderedSequence analysisAdd BLAST74
Regioni543 – 615DisorderedSequence analysisAdd BLAST73
Regioni690 – 716DisorderedSequence analysisAdd BLAST27
Regioni740 – 864DisorderedSequence analysisAdd BLAST125
Regioni889 – 1048DisorderedSequence analysisAdd BLAST160
Regioni1112 – 1218DisorderedSequence analysisAdd BLAST107
Regioni1265 – 1298DisorderedSequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 29PolarSequence analysisAdd BLAST29
Compositional biasi461 – 520PolarSequence analysisAdd BLAST60
Compositional biasi543 – 595PolarSequence analysisAdd BLAST53
Compositional biasi690 – 707PolarSequence analysisAdd BLAST18
Compositional biasi767 – 788PolarSequence analysisAdd BLAST22
Compositional biasi817 – 842PolyampholyteSequence analysisAdd BLAST26
Compositional biasi889 – 915PolarSequence analysisAdd BLAST27
Compositional biasi916 – 970PolyampholyteSequence analysisAdd BLAST55
Compositional biasi980 – 1008PolyampholyteSequence analysisAdd BLAST29
Compositional biasi1032 – 1048PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1112 – 1126PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1153 – 1170BasicSequence analysisAdd BLAST18
Compositional biasi1171 – 1190PolyampholyteSequence analysisAdd BLAST20
Compositional biasi1191 – 1206BasicSequence analysisAdd BLAST16
Compositional biasi1265 – 1280PolarSequence analysisAdd BLAST16

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1865, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154596

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005541_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		H9GJM2

Database of Orthologous Groups

More...OrthoDBi		929408at2759

TreeFam database of animal gene trees

More...TreeFami		TF315281

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR001394, Peptidase_C19_UCH
IPR018200, USP_CS
IPR028889, USP_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00443, UCH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00972, USP_1, 1 hit
PS00973, USP_2, 1 hit
PS50235, USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9GJM2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTIVDKTSES SKPSASEKQP LSSVAPASGD MDSGSAGWGA VSSSLEAPKH 
        60         70         80         90        100
KITLGPVPGA AVYSNSSVPD KSKASAQKDL SIGDGIAAPQ KVLFPADKIS 
       110        120        130        140        150
LKWQKMHRVG AGLQNLGNTC FLNSALQCLT YTPPLANYML SHEHSKTCHE 
       160        170        180        190        200
QGFCMMCTMQ SHITQALSNS GNVIKPMPVI NDLRRIAKHF RFGNQEDAHE 
       210        220        230        240        250
FLRYTVDAMQ KACLNGSNKL DRHTQATTFI HQIFGGYLRS RVKCMNCKGV 
       260        270        280        290        300
SDTFDPYLDI TLEIKSAQSI NKALEQFVKP EQLDGENAYK CSKCKKMVPA 
       310        320        330        340        350
SKRFTVHRAS NVLTLSLKRF ANFSGGKITK EVKYPEYLDI RPYMSQPNGE 
       360        370        380        390        400
PIIYALYAVL VHTGFSCHAG HYYCYIKASN GQWYQMNDST VSNSDIRTVL 
       410        420        430        440        450
NQQAYVLFYI RSHDMKNGGE HIHSAHTPGQ SSPRPVINQR VVNNKQTAPG 
       460        470        480        490        500
FIGPQLPPHM IKTSNHLNGT GSLKETASSS AIASNATLSR PSSAPPATSI 
       510        520        530        540        550
PNWTMNRPAT ATAPDPSKKQ KITISIHNNK LPGRQSVSHA SCTLDNLNKP 
       560        570        580        590        600
APSSTISNPS AVQSTSSAST ALAANQVPKQ TAPSEPSSKL VVNGKSKLSP 
       610        620        630        640        650
SMLVPYGAES SEDSDEELKG LVKENGHSKP FNGILTEKAS TVLESSCSSF 
       660        670        680        690        700
HNPEKEVPPH EPPKNITVVF SISLNDSSKQ NGQICNDSTC QAKPVKSSEN 
       710        720        730        740        750
PFSKTNGLPG KGTPIALTPV PEDRIVDSFR YNQLKPFSGD ISASGSEKPL 
       760        770        780        790        800
EEGGCSEKVP CPLTSDVQNL LAPSDPEITS TTEDPCERVP SQTGAVPLES 
       810        820        830        840        850
LGQHGLPSTP LRAKEDFPGE SNVEDHAEKT RGPKEGKAAW EKSAEVARGN 
       860        870        880        890        900
ADATEKGPQS PLLWADSECS SQKLVALNMA DKCQETQDNV KMYEDASPTE 
       910        920        930        940        950
NSCTLRPNVV GESSKDDQGE NSEQFKGNTD RQELRSHSPF REKVCTSRKT 
       960        970        980        990       1000
DKEHYRSKRK HSESEEEVEA TAGASSRSQA EGHHNKKRCS YSKERVRPQE 
      1010       1020       1030       1040       1050
HYRREHYNTN YYRFPCSPDP GRNFGKYPPY RSRSRGKTES ERSRHCYERS 
      1060       1070       1080       1090       1100
WSRERYYQDV PRRWEGCRSS DYYYPSHVPR YNQDKKFTLC ERDYNKSSHV 
      1110       1120       1130       1140       1150
YNSPYKYDYH KNRWTHDQER KRKCQSPEGS QGTPEKRPQK TVQSESLDEQ 
      1160       1170       1180       1190       1200
RGRKHKKSKK KKKLKDKHRE RDHRHHQDSD PSASSSEAEV HRHKHKKKKK 
      1210       1220       1230       1240       1250
KKKKRTKKSE DCSETLVPSL PKATSLETKN LKTWEATKSS FEACRKHGRA 
      1260       1270       1280       1290 
HQDGDTAVCQ KTKSIEGCNR NGSSPSTDHN VDPDCPLEAI PPQLAGYL
Length:1,298
Mass (Da):144,056
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF196888B554A0C16
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AAWZ02029383 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_003227691.2, XM_003227643.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSACAT00000013140; ENSACAP00000012882; ENSACAG00000013073

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100563887

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		acs:100563887

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02029383 Genomic DNA No translation available.
RefSeqiXP_003227691.2, XM_003227643.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000012882

Protein family/group databases

MEROPSiC19.048

Genome annotation databases

EnsembliENSACAT00000013140; ENSACAP00000012882; ENSACAG00000013073
GeneIDi100563887
KEGGiacs:100563887

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		84132

Phylogenomic databases

eggNOGiKOG1865, Eukaryota
GeneTreeiENSGT00940000154596
HOGENOMiCLU_005541_1_0_1
InParanoidiH9GJM2
OrthoDBi929408at2759
TreeFamiTF315281

Gene expression databases

BgeeiENSACAG00000013073, Expressed in heart and 14 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR001394, Peptidase_C19_UCH
IPR018200, USP_CS
IPR028889, USP_dom
PfamiView protein in Pfam
PF00443, UCH, 1 hit
SUPFAMiSSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00972, USP_1, 1 hit
PS00973, USP_2, 1 hit
PS50235, USP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9GJM2_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9GJM2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: June 26, 2013
Last modified: December 2, 2020
This is version 55 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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