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Entry version 55 (02 Dec 2020)
Sequence version 2 (26 Jun 2013)
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Protein

USP domain-containing protein

Gene

USP42

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C19.048

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
USP domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:USP42Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000013073, Expressed in heart and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000012882

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini111 – 412USPInterPro annotationAdd BLAST302

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 40DisorderedSequence analysisAdd BLAST40
Regioni447 – 520DisorderedSequence analysisAdd BLAST74
Regioni543 – 615DisorderedSequence analysisAdd BLAST73
Regioni690 – 716DisorderedSequence analysisAdd BLAST27
Regioni740 – 864DisorderedSequence analysisAdd BLAST125
Regioni889 – 1048DisorderedSequence analysisAdd BLAST160
Regioni1112 – 1218DisorderedSequence analysisAdd BLAST107
Regioni1265 – 1298DisorderedSequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 29PolarSequence analysisAdd BLAST29
Compositional biasi461 – 520PolarSequence analysisAdd BLAST60
Compositional biasi543 – 595PolarSequence analysisAdd BLAST53
Compositional biasi690 – 707PolarSequence analysisAdd BLAST18
Compositional biasi767 – 788PolarSequence analysisAdd BLAST22
Compositional biasi817 – 842PolyampholyteSequence analysisAdd BLAST26
Compositional biasi889 – 915PolarSequence analysisAdd BLAST27
Compositional biasi916 – 970PolyampholyteSequence analysisAdd BLAST55
Compositional biasi980 – 1008PolyampholyteSequence analysisAdd BLAST29
Compositional biasi1032 – 1048PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1112 – 1126PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1153 – 1170BasicSequence analysisAdd BLAST18
Compositional biasi1171 – 1190PolyampholyteSequence analysisAdd BLAST20
Compositional biasi1191 – 1206BasicSequence analysisAdd BLAST16
Compositional biasi1265 – 1280PolarSequence analysisAdd BLAST16

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1865, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154596

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005541_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H9GJM2

Database of Orthologous Groups

More...
OrthoDBi
929408at2759

TreeFam database of animal gene trees

More...
TreeFami
TF315281

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR001394, Peptidase_C19_UCH
IPR018200, USP_CS
IPR028889, USP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00443, UCH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00972, USP_1, 1 hit
PS00973, USP_2, 1 hit
PS50235, USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9GJM2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTIVDKTSES SKPSASEKQP LSSVAPASGD MDSGSAGWGA VSSSLEAPKH
60 70 80 90 100
KITLGPVPGA AVYSNSSVPD KSKASAQKDL SIGDGIAAPQ KVLFPADKIS
110 120 130 140 150
LKWQKMHRVG AGLQNLGNTC FLNSALQCLT YTPPLANYML SHEHSKTCHE
160 170 180 190 200
QGFCMMCTMQ SHITQALSNS GNVIKPMPVI NDLRRIAKHF RFGNQEDAHE
210 220 230 240 250
FLRYTVDAMQ KACLNGSNKL DRHTQATTFI HQIFGGYLRS RVKCMNCKGV
260 270 280 290 300
SDTFDPYLDI TLEIKSAQSI NKALEQFVKP EQLDGENAYK CSKCKKMVPA
310 320 330 340 350
SKRFTVHRAS NVLTLSLKRF ANFSGGKITK EVKYPEYLDI RPYMSQPNGE
360 370 380 390 400
PIIYALYAVL VHTGFSCHAG HYYCYIKASN GQWYQMNDST VSNSDIRTVL
410 420 430 440 450
NQQAYVLFYI RSHDMKNGGE HIHSAHTPGQ SSPRPVINQR VVNNKQTAPG
460 470 480 490 500
FIGPQLPPHM IKTSNHLNGT GSLKETASSS AIASNATLSR PSSAPPATSI
510 520 530 540 550
PNWTMNRPAT ATAPDPSKKQ KITISIHNNK LPGRQSVSHA SCTLDNLNKP
560 570 580 590 600
APSSTISNPS AVQSTSSAST ALAANQVPKQ TAPSEPSSKL VVNGKSKLSP
610 620 630 640 650
SMLVPYGAES SEDSDEELKG LVKENGHSKP FNGILTEKAS TVLESSCSSF
660 670 680 690 700
HNPEKEVPPH EPPKNITVVF SISLNDSSKQ NGQICNDSTC QAKPVKSSEN
710 720 730 740 750
PFSKTNGLPG KGTPIALTPV PEDRIVDSFR YNQLKPFSGD ISASGSEKPL
760 770 780 790 800
EEGGCSEKVP CPLTSDVQNL LAPSDPEITS TTEDPCERVP SQTGAVPLES
810 820 830 840 850
LGQHGLPSTP LRAKEDFPGE SNVEDHAEKT RGPKEGKAAW EKSAEVARGN
860 870 880 890 900
ADATEKGPQS PLLWADSECS SQKLVALNMA DKCQETQDNV KMYEDASPTE
910 920 930 940 950
NSCTLRPNVV GESSKDDQGE NSEQFKGNTD RQELRSHSPF REKVCTSRKT
960 970 980 990 1000
DKEHYRSKRK HSESEEEVEA TAGASSRSQA EGHHNKKRCS YSKERVRPQE
1010 1020 1030 1040 1050
HYRREHYNTN YYRFPCSPDP GRNFGKYPPY RSRSRGKTES ERSRHCYERS
1060 1070 1080 1090 1100
WSRERYYQDV PRRWEGCRSS DYYYPSHVPR YNQDKKFTLC ERDYNKSSHV
1110 1120 1130 1140 1150
YNSPYKYDYH KNRWTHDQER KRKCQSPEGS QGTPEKRPQK TVQSESLDEQ
1160 1170 1180 1190 1200
RGRKHKKSKK KKKLKDKHRE RDHRHHQDSD PSASSSEAEV HRHKHKKKKK
1210 1220 1230 1240 1250
KKKKRTKKSE DCSETLVPSL PKATSLETKN LKTWEATKSS FEACRKHGRA
1260 1270 1280 1290
HQDGDTAVCQ KTKSIEGCNR NGSSPSTDHN VDPDCPLEAI PPQLAGYL
Length:1,298
Mass (Da):144,056
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF196888B554A0C16
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAWZ02029383 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_003227691.2, XM_003227643.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000013140; ENSACAP00000012882; ENSACAG00000013073

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100563887

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
acs:100563887

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02029383 Genomic DNA No translation available.
RefSeqiXP_003227691.2, XM_003227643.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000012882

Protein family/group databases

MEROPSiC19.048

Genome annotation databases

EnsembliENSACAT00000013140; ENSACAP00000012882; ENSACAG00000013073
GeneIDi100563887
KEGGiacs:100563887

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84132

Phylogenomic databases

eggNOGiKOG1865, Eukaryota
GeneTreeiENSGT00940000154596
HOGENOMiCLU_005541_1_0_1
InParanoidiH9GJM2
OrthoDBi929408at2759
TreeFamiTF315281

Gene expression databases

BgeeiENSACAG00000013073, Expressed in heart and 14 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR001394, Peptidase_C19_UCH
IPR018200, USP_CS
IPR028889, USP_dom
PfamiView protein in Pfam
PF00443, UCH, 1 hit
SUPFAMiSSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00972, USP_1, 1 hit
PS00973, USP_2, 1 hit
PS50235, USP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9GJM2_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9GJM2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: June 26, 2013
Last modified: December 2, 2020
This is version 55 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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