UniProtKB - H9GJL4 (H9GJL4_ANOCA)
Protein
Protein kinase domain-containing protein
Gene
IKBKE
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- identical protein binding Source: Ensembl
- IkappaB kinase activity Source: Ensembl
- K48-linked polyubiquitin modification-dependent protein binding Source: Ensembl
- NF-kappaB-inducing kinase activity Source: Ensembl
- protein serine/threonine kinase activity Source: GO_Central
- ubiquitin protein ligase binding Source: Ensembl
GO - Biological processi
- cellular response to virus Source: Ensembl
- intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
- peptidyl-serine phosphorylation Source: GO_Central
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
- positive regulation of lipid storage Source: Ensembl
- positive regulation of type I interferon-mediated signaling pathway Source: Ensembl
- response to interferon-beta Source: Ensembl
- response to type I interferon Source: Ensembl
Keywordsi
Molecular function | TransferaseARBA annotation |
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Protein kinase domain-containing proteinInterPro annotation |
Gene namesi | Name:IKBKEImported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Other locations
- Cytoplasm ARBA annotation
Mitochondrion
- mitochondrial membrane Source: Ensembl
Nucleus
- PML body Source: Ensembl
Other locations
- cytoplasm Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSACAG00000013031, Expressed in adrenal gland and 11 other tissues |
Interactioni
GO - Molecular functioni
- identical protein binding Source: Ensembl
- K48-linked polyubiquitin modification-dependent protein binding Source: Ensembl
- ubiquitin protein ligase binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000012863 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 310 | Protein kinaseInterPro annotationAdd BLAST | 302 |
Phylogenomic databases
eggNOGi | KOG4250, Eukaryota |
GeneTreei | ENSGT00950000182937 |
HOGENOMi | CLU_000288_101_1_1 |
InParanoidi | H9GJL4 |
OrthoDBi | 563981at2759 |
TreeFami | TF324269 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR041309, TBK1_CCD1 IPR041087, TBK1_ULD |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit PF18394, TBK1_CCD1, 1 hit PF18396, TBK1_ULD, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit |
i Sequence
Sequence statusi: Complete.
H9GJL4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQSTLNYLWK TDDVLGQGAT ASVYKARNKI SGELVAVKVF NSVSYLRPQE
60 70 80 90 100
VQIREFEVLR KLNHQNIVKL FSVEEIEISK QKVLVMEYCS GGSLLSLLEE
110 120 130 140 150
PENAFGLSES EFLIVLHCVV SGMNHLRENG IVHRDIKPGN IMRLTSEDRQ
160 170 180 190 200
SIYKLSDFGA ARELDDDEKF ESVYGTEEYL HPDIYKRAVL KKPQQKAYGV
210 220 230 240 250
TVDLWSIGVT FYHAATGSLP FIPFGGPRRN KEIMYKITTE KPTGAIAGVQ
260 270 280 290 300
EQENGAIIWT DELPISCQLS LGLKRPLVPI LANILEADQE ECWSFDQFFA
310 320 330 340 350
EANDILHRTI IHVFSLSQAV MLHVYIHPYN TAIKFLEEVF RQTSTAPCHQ
360 370 380 390 400
EYLFEGHSYE LEPNLQVCHF PKTTETCPFI LMSTDPEDPV GLRYRDPTLE
410 420 430 440 450
FPRFLPKVDV IADCSTAKGV LSATHQTLRI SQSFLKDQEL ILRGLYWLSE
460 470 480 490 500
TLKSKCPQFL EKRQAVMGML SFTQQIEMKL LLLYEAVTGD SGIPEMKGVT
510 520 530 540 550
ELKTRLQAIS EEISRCSHSI SEQQAALQGI LSEVGKKQNQ MKEDRSIQKM
560 570 580 590 600
EACLDKMQLI YAQFKKARKC PRLGYNEQQI HKLDKLNLGH SAKKVISVFQ
610 620 630 640 650
DNSEHQYRAA LSGHGTRMRK AFEIQKNLKK LNRSLTTCST EMSGCQDCLV
660 670 680 690 700
KVLDELHQRT LQGKTTSSVP TQVCLNQKHK DVAFGIQELQ DQMKIVAHNL
710
QLNNNIIQRL NGVAPGL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02020766 Genomic DNA No translation available. AAWZ02020767 Genomic DNA No translation available. AAWZ02020768 Genomic DNA No translation available. |
RefSeqi | XP_008113864.1, XM_008115657.2 |
Genome annotation databases
Ensembli | ENSACAT00000013120; ENSACAP00000012863; ENSACAG00000013031 |
GeneIDi | 100562496 |
KEGGi | acs:100562496 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02020766 Genomic DNA No translation available. AAWZ02020767 Genomic DNA No translation available. AAWZ02020768 Genomic DNA No translation available. |
RefSeqi | XP_008113864.1, XM_008115657.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000012863 |
Genome annotation databases
Ensembli | ENSACAT00000013120; ENSACAP00000012863; ENSACAG00000013031 |
GeneIDi | 100562496 |
KEGGi | acs:100562496 |
Organism-specific databases
CTDi | 9641 |
Phylogenomic databases
eggNOGi | KOG4250, Eukaryota |
GeneTreei | ENSGT00950000182937 |
HOGENOMi | CLU_000288_101_1_1 |
InParanoidi | H9GJL4 |
OrthoDBi | 563981at2759 |
TreeFami | TF324269 |
Gene expression databases
Bgeei | ENSACAG00000013031, Expressed in adrenal gland and 11 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR041309, TBK1_CCD1 IPR041087, TBK1_ULD |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit PF18394, TBK1_CCD1, 1 hit PF18396, TBK1_ULD, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H9GJL4_ANOCA | |
Accessioni | H9GJL4Primary (citable) accession number: H9GJL4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | June 26, 2013 | |
Last modified: | December 2, 2020 | |
This is version 50 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |