Protein kinase domain-containing protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATP binding Source: UniProtKB-KW
• identical protein binding Source: Ensembl
• IkappaB kinase activity Source: Ensembl
• K48-linked polyubiquitin modification-dependent protein binding Source: Ensembl
• NF-kappaB-inducing kinase activity Source: Ensembl
• protein serine/threonine kinase activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• ubiquitin protein ligase binding Source: Ensembl

GO - Biological processⁱ

• cellular response to virus Source: Ensembl
• intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
• peptidyl-serine phosphorylation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
• positive regulation of lipid storage Source: Ensembl
• positive regulation of type I interferon-mediated signaling pathway Source: Ensembl
• response to interferon-beta Source: Ensembl
• response to type I interferon Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• identical protein binding Source: Ensembl
• K48-linked polyubiquitin modification-dependent protein binding Source: Ensembl
• ubiquitin protein ligase binding Source: Ensembl

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MQSTLNYLWK TDDVLGQGAT ASVYKARNKI SGELVAVKVF NSVSYLRPQE 
        60         70         80         90        100
VQIREFEVLR KLNHQNIVKL FSVEEIEISK QKVLVMEYCS GGSLLSLLEE 
       110        120        130        140        150
PENAFGLSES EFLIVLHCVV SGMNHLRENG IVHRDIKPGN IMRLTSEDRQ 
       160        170        180        190        200
SIYKLSDFGA ARELDDDEKF ESVYGTEEYL HPDIYKRAVL KKPQQKAYGV 
       210        220        230        240        250
TVDLWSIGVT FYHAATGSLP FIPFGGPRRN KEIMYKITTE KPTGAIAGVQ 
       260        270        280        290        300
EQENGAIIWT DELPISCQLS LGLKRPLVPI LANILEADQE ECWSFDQFFA 
       310        320        330        340        350
EANDILHRTI IHVFSLSQAV MLHVYIHPYN TAIKFLEEVF RQTSTAPCHQ 
       360        370        380        390        400
EYLFEGHSYE LEPNLQVCHF PKTTETCPFI LMSTDPEDPV GLRYRDPTLE 
       410        420        430        440        450
FPRFLPKVDV IADCSTAKGV LSATHQTLRI SQSFLKDQEL ILRGLYWLSE 
       460        470        480        490        500
TLKSKCPQFL EKRQAVMGML SFTQQIEMKL LLLYEAVTGD SGIPEMKGVT 
       510        520        530        540        550
ELKTRLQAIS EEISRCSHSI SEQQAALQGI LSEVGKKQNQ MKEDRSIQKM 
       560        570        580        590        600
EACLDKMQLI YAQFKKARKC PRLGYNEQQI HKLDKLNLGH SAKKVISVFQ 
       610        620        630        640        650
DNSEHQYRAA LSGHGTRMRK AFEIQKNLKK LNRSLTTCST EMSGCQDCLV 
       660        670        680        690        700
KVLDELHQRT LQGKTTSSVP TQVCLNQKHK DVAFGIQELQ DQMKIVAHNL 
       710 
QLNNNIIQRL NGVAPGL                                     

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ