UniProtKB - H9GJC4 (H9GJC4_ANOCA)
Protein
Protein kinase domain-containing protein
Gene
TAOK1
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
GO - Molecular functioni
- alpha-tubulin binding Source: Ensembl
- ATP binding Source: UniProtKB-KW
- beta-tubulin binding Source: Ensembl
- protein serine/threonine kinase activity Source: GO_Central
GO - Biological processi
- activation of protein kinase activity Source: GO_Central
- execution phase of apoptosis Source: GO_Central
- MAPK cascade Source: GO_Central
- microtubule cytoskeleton organization Source: Ensembl
- mitotic G2 DNA damage checkpoint Source: Ensembl
- negative regulation of microtubule depolymerization Source: Ensembl
- neuron cellular homeostasis Source: Ensembl
- neuron projection morphogenesis Source: GO_Central
- positive regulation of JNK cascade Source: Ensembl
- positive regulation of protein acetylation Source: Ensembl
- signal transduction by protein phosphorylation Source: GO_Central
- stress-activated protein kinase signaling cascade Source: GO_Central
Keywordsi
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Protein kinase domain-containing proteinInterPro annotation |
Gene namesi | Name:TAOK1Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Cytoskeleton
- microtubule cytoskeleton Source: Ensembl
Other locations
- cytoplasm Source: GO_Central
- perinuclear region of cytoplasm Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSACAG00000012732, Expressed in skeletal muscle tissue and 15 other tissues |
Interactioni
GO - Molecular functioni
- alpha-tubulin binding Source: Ensembl
- beta-tubulin binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000012626 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 281 | Protein kinaseInterPro annotationAdd BLAST | 254 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 324 – 435 | DisorderedSequence analysisAdd BLAST | 112 | |
Regioni | 567 – 587 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 906 – 1012 | DisorderedSequence analysisAdd BLAST | 107 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 464 – 491 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 497 – 535 | Sequence analysisAdd BLAST | 39 | |
Coiled coili | 626 – 646 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 754 – 774 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 831 – 862 | Sequence analysisAdd BLAST | 32 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 340 – 374 | PolarSequence analysisAdd BLAST | 35 | |
Compositional biasi | 400 – 415 | PolyampholyteSequence analysisAdd BLAST | 16 | |
Compositional biasi | 971 – 1012 | PolarSequence analysisAdd BLAST | 42 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG0577, Eukaryota |
GeneTreei | ENSGT00940000155796 |
HOGENOMi | CLU_000288_2_2_1 |
InParanoidi | H9GJC4 |
OMAi | XAKVMAN |
OrthoDBi | 617606at2759 |
TreeFami | TF351444 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
H9GJC4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPSTNRAGSL KDPEVAELFF KEDPEKLFSD LREIGHGSFG AVYFARDVRT
60 70 80 90 100
NEVVAIKKMS YSGKQSNEKW QDIVKEVKFL QRIQHPNSIE YKGCYLREHT
110 120 130 140 150
AWLVMEYCLG SASDLLEVHK KPLQEVEIAA ITHGALQGLA YLHSHNMIHR
160 170 180 190 200
DIKAGNILLT EPGQVKLADF GSASIASPAN SFVGTPYWMA PEVILAMDEG
210 220 230 240 250
QYDGKVDVWS LGITCIELAE RKPPLFNMNA MSALYHIAQN ESPTLQSNEW
260 270 280 290 300
SDYFRNFVDS CLQKIPQDRP TSEELLKHVF VQRERPETVL IELIQRTKDA
310 320 330 340 350
VRELDNLQYR KMKKLLFQEA HNGPAVEAQE EEEEQEHGVG RTGTVNSVGS
360 370 380 390 400
NQSIPSMSIS ASSQSSSVNS LPDASDDKSE LDMMEGDHTV MSNSSVIHLK
410 420 430 440 450
PEEESYREDS ESRARGSEPQ SPPQASRHRS HYRNREHFAT IRTASLVTRQ
460 470 480 490 500
MQEHEQDSEL REQMSGYKRM RRQHQKQLMA LENKLKTEMD EHRLRLDKDL
510 520 530 540 550
ETQRNNFAAE MEKLLKKHQA AMEKEAKVMA NEEKKFQQHI QGQQKKELNS
560 570 580 590 600
FLESQKREYK LRKEQLKEEL SENQSTPKKE KQEWLSKQKE NIQHFQAEEE
610 620 630 640 650
ANLLRRQRQY LELECRRFKR RMLLARHNLE QDLVREELNK RQTQKDLEHA
660 670 680 690 700
MLLRQHESMQ ELEFRHLGTI QKMRCELIRL QHQTELTNQL EYNKRREREL
710 720 730 740 750
RRKHVMEVRQ QPKSLKSKEL QIKKQFQDTC KIQTRQYKAL RNHLLETTPK
760 770 780 790 800
SEHKAVLKRL KEEQTRKLAI LAEQYDHSIN EMLSTQALRL DEAQEAECQV
810 820 830 840 850
LKMQLQQELE LLNAYQSKIK MQAEAQHDRE LRELEQRVSL RRALLEQKIE
860 870 880 890 900
EEMLALQNER TERIRSLLER QAREIEAFDS ESMRLGFSNM VLSNLSPEAF
910 920 930 940 950
SHSYPGASGW SHHPSAPPHP GPHWGHPVMA QGVPPQAWGH PMMQGGGGGG
960 970 980 990 1000
VPQPWGHPSG AMAGVPRGSS LGVRNSPQAL RRTASGGRTE PGMSRSASVT
1010
SQISNGSHMS YT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02028408 Genomic DNA No translation available. AAWZ02028409 Genomic DNA No translation available. |
RefSeqi | XP_003227215.1, XM_003227167.3 |
Genome annotation databases
Ensembli | ENSACAT00000012882; ENSACAP00000012626; ENSACAG00000012732 |
GeneIDi | 100561719 |
KEGGi | acs:100561719 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02028408 Genomic DNA No translation available. AAWZ02028409 Genomic DNA No translation available. |
RefSeqi | XP_003227215.1, XM_003227167.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000012626 |
Genome annotation databases
Ensembli | ENSACAT00000012882; ENSACAP00000012626; ENSACAG00000012732 |
GeneIDi | 100561719 |
KEGGi | acs:100561719 |
Organism-specific databases
CTDi | 57551 |
Phylogenomic databases
eggNOGi | KOG0577, Eukaryota |
GeneTreei | ENSGT00940000155796 |
HOGENOMi | CLU_000288_2_2_1 |
InParanoidi | H9GJC4 |
OMAi | XAKVMAN |
OrthoDBi | 617606at2759 |
TreeFami | TF351444 |
Gene expression databases
Bgeei | ENSACAG00000012732, Expressed in skeletal muscle tissue and 15 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H9GJC4_ANOCA | |
Accessioni | H9GJC4Primary (citable) accession number: H9GJC4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | May 16, 2012 | |
Last modified: | December 2, 2020 | |
This is version 63 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |