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UniProtKB - H9GJA2 (H9GJA2_ANOCA)

Entry version 36 (12 Aug 2020)
Sequence version 2 (26 Jun 2013)
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Protein
Submitted name:

Otoancorin

Gene

OTOA

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
OtoancorinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OTOAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

MembraneARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSACAG00000012735, Expressed in dewlap and 6 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		28377.ENSACAP00000012581

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili342 – 362Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the mesothelin family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QU5H, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182957

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_291462_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		H9GJA2

TreeFam database of animal gene trees

More...TreeFami		TF336607

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR010335, Mesothelin
IPR026663, Otoancorin
IPR026664, Stereocilin-rel

The PANTHER Classification System

More...PANTHERi		PTHR23412, PTHR23412, 1 hit
PTHR23412:SF18, PTHR23412:SF18, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06060, Mesothelin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9GJA2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VPDSLQNLSP QLQNIVEEVM AGNYLNALLD ILHYQSTHMW TTELLNKVLA 
        60         70         80         90        100
YFDAQNIIVT YSNIQASVKT YLENLLYHPR VLLSEFQQMN LQRFQTAMKY 
       110        120        130        140        150
LFGNKQEYLE LGNVVIDLAG IRERIFQSPG GNRTLFLTTL ERCFQSLSSA 
       160        170        180        190        200
ECVNILSQIL RASSIMYLQV HTIPNLPKDL QEDAFRNLSS VFRDLYDRIT 
       210        220        230        240        250
ASSQRALYDW MMQILQKSYN ISENATSWVS AENLWILGRY MVHLPLEEIW 
       260        270        280        290        300
KIHPNEMRLF ISYDNATKQL DTVYDITPDL AQAFLERINA SGFDMKNIST 
       310        320        330        340        350
LYRLGLLVCF YNDLEQMDAN VARVLLHQMI KCNHLRGSQA DIQKLKSQLL 
       360        370        380        390        400
DLALQNQTLN ESLGSLSDAV VGLSTNQLDS LSPEAVHNAI QTLNQVSGWA 
       410        420        430        440        450
RSQIMILSRK YLMYEKILSL HNISQMGALV TGISTQSFHS MSPKELSQLI 
       460        470        480        490        500
RGALAERASD LSPAQRQGIL RKIIASTELS SVFADMQGPF FKELSLFDLW 
       510        520        530        540        550
TGEGFNSSLV KERELRPSQA LFLYELLSKK TPLSELLSID QMVKGITCWQ 
       560        570        580        590        600
IDRMSPITFV NVSNILKRIS TASSIVPEKP EEANRCKGSG YSCCILNGSP 
       610        620        630        640        650
FFCTKLFPEY LEAITGSLCV PFITSLRKIE LDRLVLNEQK KNAILQKVHN 
       660        670        680        690        700
CLNGSIVDEY DLDLIGNLIC HLSPALICVG SLETMATALQ QFGQCQHLSH 
       710        720        730        740        750
EQEMDIKRWI IDLYGSPRNW TTETTQDIGP FIALLTKTDL SILVEKKFPG 
       760        770        780        790        800
FISDIASKKS GPVPPSEELL LAYFEWVRNS SIPFSAPNGT FGCAEVAAPS 
       810        820        830        840        850
SDEIMKLTEA NKFWSDQELF CMDPGTFNKT VELLGSVGSL SASQLTVLKE 
       860        870        880        890        900
KAKQVWGPLT SWQNYHIVSL GRIATTLNET EIGALNLSSI DTIAALSEQT 
       910        920        930        940        950
EWNPSQTQSI LHGFLEDSGQ EMSTLKSFDL AGLGASLCAL NSTEIAAINA 
       960        970        980        990       1000
NEFSAVVARI GSLLCSSIVL ESFKKKAESV FGIAATWDKS ILQEIGTIAA 
      1010       1020       1030       1040       1050
AGLNDTELKA VDKELMPYFH PRAIKCIPDE MFKELSPEQL ASLGPTNAAM 
      1060       1070       1080       1090       1100
VTESQHRHLN ELQLQSLQQA LDGTRRSTNQ SPFGESTIKP TYTSVLSGAS 
      1110       1120 
FSCRLSLWVL AVFIWYPASI PTVTV
Length:1,125
Mass (Da):125,618
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3C7A16DFE972B856
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AAWZ02029380 Genomic DNA No translation available.
AAWZ02029381 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSACAT00000012837; ENSACAP00000012581; ENSACAG00000012735

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02029380 Genomic DNA No translation available.
AAWZ02029381 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000012581

Genome annotation databases

EnsembliENSACAT00000012837; ENSACAP00000012581; ENSACAG00000012735

Phylogenomic databases

eggNOGiENOG502QU5H, Eukaryota
GeneTreeiENSGT00950000182957
HOGENOMiCLU_291462_0_0_1
InParanoidiH9GJA2
TreeFamiTF336607

Gene expression databases

BgeeiENSACAG00000012735, Expressed in dewlap and 6 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR010335, Mesothelin
IPR026663, Otoancorin
IPR026664, Stereocilin-rel
PANTHERiPTHR23412, PTHR23412, 1 hit
PTHR23412:SF18, PTHR23412:SF18, 1 hit
PfamiView protein in Pfam
PF06060, Mesothelin, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9GJA2_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9GJA2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: June 26, 2013
Last modified: August 12, 2020
This is version 36 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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