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Entry version 60 (07 Oct 2020)
Sequence version 1 (16 May 2012)
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Protein
Submitted name:

Ankyrin 1

Gene

ANK1

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ankyrin 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANK1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000012052, Expressed in lung and 12 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000012133

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 797ANK_REP_REGIONInterPro annotationAdd BLAST791
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati40 – 72ANKPROSITE-ProRule annotationAdd BLAST33
Repeati73 – 105ANKPROSITE-ProRule annotationAdd BLAST33
Repeati106 – 138ANKPROSITE-ProRule annotationAdd BLAST33
Repeati139 – 163ANKPROSITE-ProRule annotationAdd BLAST25
Repeati201 – 233ANKPROSITE-ProRule annotationAdd BLAST33
Repeati234 – 266ANKPROSITE-ProRule annotationAdd BLAST33
Repeati267 – 299ANKPROSITE-ProRule annotationAdd BLAST33
Repeati300 – 332ANKPROSITE-ProRule annotationAdd BLAST33
Repeati333 – 365ANKPROSITE-ProRule annotationAdd BLAST33
Repeati366 – 398ANKPROSITE-ProRule annotationAdd BLAST33
Repeati399 – 431ANKPROSITE-ProRule annotationAdd BLAST33
Repeati432 – 464ANKPROSITE-ProRule annotationAdd BLAST33
Repeati465 – 497ANKPROSITE-ProRule annotationAdd BLAST33
Repeati498 – 530ANKPROSITE-ProRule annotationAdd BLAST33
Repeati531 – 563ANKPROSITE-ProRule annotationAdd BLAST33
Repeati564 – 590ANKPROSITE-ProRule annotationAdd BLAST27
Repeati597 – 629ANKPROSITE-ProRule annotationAdd BLAST33
Repeati630 – 662ANKPROSITE-ProRule annotationAdd BLAST33
Repeati663 – 695ANKPROSITE-ProRule annotationAdd BLAST33
Repeati696 – 728ANKPROSITE-ProRule annotationAdd BLAST33
Repeati729 – 761ANKPROSITE-ProRule annotationAdd BLAST33
Domaini909 – 1064ZU5InterPro annotationAdd BLAST156
Domaini1066 – 1212ZU5InterPro annotationAdd BLAST147

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni814 – 833DisorderedSequence analysisAdd BLAST20
Regioni870 – 899DisorderedSequence analysisAdd BLAST30
Regioni1567 – 1605DisorderedSequence analysisAdd BLAST39
Regioni1624 – 1674DisorderedSequence analysisAdd BLAST51
Regioni1691 – 1715DisorderedSequence analysisAdd BLAST25
Regioni1740 – 1760DisorderedSequence analysisAdd BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1025 – 1045Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi817 – 833PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1624 – 1640PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1648 – 1665PolarSequence analysisAdd BLAST18

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis, RepeatARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4177, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155760

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000134_7_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H9GIT7

Identification of Orthologs from Complete Genome Data

More...
OMAi
AQHILCH

TreeFam database of animal gene trees

More...
TreeFami
TF351263

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR000906, ZU5_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023, Ank, 2 hits
PF12796, Ank_2, 6 hits
PF17809, UPA_2, 1 hit
PF00791, ZU5, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 23 hits
SM00218, ZU5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 21 hits
PS51145, ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9GIT7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDFCRADAAT SFLRAARSGN LDKALDHLRN GVDINTCNQN GLNALHLASK
60 70 80 90 100
EGHVKMVAEL LHKEIVLETT TKKGNTALHI AALAGQEDVV RELVNFGANV
110 120 130 140 150
NAQSQKGFTP LYMAAQENHL EVVKFLLENG ANQNVATEDG FTPLAVALQQ
160 170 180 190 200
GHENVVAHLI NYGTKGKVRL PALHIAARND DTRTAAVLLQ NDPNADVLSK
210 220 230 240 250
TGFTPLHIAA HYENLNVAQL LLNRGASVNF TPQNGITPLH IASRRGNIIM
260 270 280 290 300
VRLLLDRGAQ IETRTKDELT PLHCASRNGH VRIAEILLDH GAPIQAKTKN
310 320 330 340 350
GLSPIHMASQ GDHLDCVRLL LQYNADIDDI TLDHLTPLHV AAHCGHHRVA
360 370 380 390 400
KVLLDKGAKP NARALNGFTP LHIACKKNHI RVMELLLKTG ASIDAVTESG
410 420 430 440 450
LTPLHVASFM GNLPIVKILL QRGASPNVSN VKVETPLHMA ARAGHTEVAK
460 470 480 490 500
YLLQNKAKVN AKAKDDQTPL HCAARLGHCS MVKLLLENGA DPNLSTTAGH
510 520 530 540 550
TPLHITAREG HLDCACALLE KEASQTVMTK KGFTPLHVAS KYGKVDVAEV
560 570 580 590 600
LLEHNAQPNA AGKNGLTPLH VAVHHNNLDI VKVLLPKGAS PHSVAWNGYT
610 620 630 640 650
PLHIAARQNQ MEVASSLLQY GASANAESTQ GVTPLHLAAQ EGHADMVLLL
660 670 680 690 700
LSKQANGNLG NKSGLTPLHL VAQEGHVHVA DVLLRHGVRV DATTRMGYTP
710 720 730 740 750
LHVACHYGNI KLVKFLLQHQ ADVNSKTKLG YTPLHQAAQQ GHTDIVTLLL
760 770 780 790 800
KHGASPNEVS SNGATPLAIA KRLGYISVTD VLKIVTEETS FVPLSDKHRM
810 820 830 840 850
SFPETVDEIL DVSEDEGEEL PGPKSHKREY QYQDDEREIV EFVPKLDHAE
860 870 880 890 900
ESPAIPRIPC VTPETVLIRP EEPEQPSKEF DEESLIPSSP ATETSDNISP
910 920 930 940 950
VASPVHTGFL VSFMVDARGG SMRGSRHNGL RVIIPPRTCA APTRITCRLV
960 970 980 990 1000
KPQKLPAPPP LAEEEGLASR IIALGPAGAQ FLSPVIVEIP HFASHGRGDR
1010 1020 1030 1040 1050
ELVILRSENG SVWKEHRSRY GENYLDQVLN GMDEELESLE ELEKKRICRI
1060 1070 1080 1090 1100
ITTDFPLYFV VMSRVSQDCE LIGPEGGSLQ STLVPLVQAT FPETAVTKKV
1110 1120 1130 1140 1150
KLALQAQPVP DELVTKLLGN QATFSPIVTV EPRRRKFHRP IGLRVPLPPS
1160 1170 1180 1190 1200
WRENPRDSGE GDTTSLRLLC SVIGGTAPAQ WEDITGTTKL VYANECANFT
1210 1220 1230 1240 1250
TNVSARFWLA DCPRTAEAVH FATLLYKDLA AVPYMAKFVV FAKMNDGREG
1260 1270 1280 1290 1300
RLRCYCMTDD KVDKTLEQHE NFTEVARSRD IEVVEGMPLH TELSGNLVPI
1310 1320 1330 1340 1350
KKAAQQRSFL FQSFHENRLI IPVKVRLSGS RRGFEVKATK YKPSFSALFL
1360 1370 1380 1390 1400
RLKKPPSAYT QVRVLVGLYL GQLILNTGVI GGTGSTFRLA ISKRFEDNGW
1410 1420 1430 1440 1450
GVAANPPDRL VKYISHHRKK ELPGSGATLE SAFLGFLGYL RGCPLTVENL
1460 1470 1480 1490 1500
YTALRNIDRS EIINMLEGSA RQSRSLKGDK RYSNRDYSLS PSQMNGYASL
1510 1520 1530 1540 1550
QDELLSPASL HYALPSPLRA DQYWSEVAIM DAIPMAASEQ DALMEMSDMQ
1560 1570 1580 1590 1600
VWSSGLTPSL VTAEDSSLEC SKAEDSDATS EGRFPGQIQE DAHCGPDPLG
1610 1620 1630 1640 1650
SMDLVEDDTV DSDAMNGLMD MLEQEEGQRS EGRRPDGASA GADSHSDLSL
1660 1670 1680 1690 1700
LAGQQKVQAR ITESPSVSRV IDKGKDRQKL DWGCCMMRGR ERERPEHMRI
1710 1720 1730 1740 1750
DSSEERESPP PHKEWALHPG RRQGLTQWLK ETTDSSFFGQ TQVGGCKGSR
1760 1770 1780 1790
PRGIGAPEEP FKGLFFFQGN EALDIPGEQV TEEQFTDEQG NIITKKV
Length:1,797
Mass (Da):196,759
Last modified:May 16, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3ED7A41ACD7CB643
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAWZ02030016 Genomic DNA No translation available.
AAWZ02030017 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000012378; ENSACAP00000012133; ENSACAG00000012052

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02030016 Genomic DNA No translation available.
AAWZ02030017 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000012133

Genome annotation databases

EnsembliENSACAT00000012378; ENSACAP00000012133; ENSACAG00000012052

Phylogenomic databases

eggNOGiKOG4177, Eukaryota
GeneTreeiENSGT00940000155760
HOGENOMiCLU_000134_7_2_1
InParanoidiH9GIT7
OMAiAQHILCH
TreeFamiTF351263

Gene expression databases

BgeeiENSACAG00000012052, Expressed in lung and 12 other tissues

Family and domain databases

Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR000906, ZU5_dom
PfamiView protein in Pfam
PF00023, Ank, 2 hits
PF12796, Ank_2, 6 hits
PF17809, UPA_2, 1 hit
PF00791, ZU5, 1 hit
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 23 hits
SM00218, ZU5, 1 hit
SUPFAMiSSF48403, SSF48403, 2 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 21 hits
PS51145, ZU5, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9GIT7_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9GIT7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: October 7, 2020
This is version 60 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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