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UniProtKB - H9GIS7 (H9GIS7_ANOCA)

Entry version 63 (07 Oct 2020)
Sequence version 1 (16 May 2012)
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Protein
Submitted name:

Euchromatic histone lysine methyltransferase 1

Gene

EHMT1

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Euchromatic histone lysine methyltransferase 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EHMT1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSACAG00000012200, Expressed in hemipenis and 15 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		28377.ENSACAP00000012109

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini707 – 942ANK_REP_REGIONInterPro annotationAdd BLAST236
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati737 – 769ANKPROSITE-ProRule annotationAdd BLAST33
Repeati770 – 802ANKPROSITE-ProRule annotationAdd BLAST33
Repeati803 – 836ANKPROSITE-ProRule annotationAdd BLAST34
Repeati837 – 869ANKPROSITE-ProRule annotationAdd BLAST33
Repeati903 – 935ANKPROSITE-ProRule annotationAdd BLAST33
Domaini1028 – 1091Pre-SETInterPro annotationAdd BLAST64
Domaini1094 – 1211SETInterPro annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 53DisorderedSequence analysisAdd BLAST53
Regioni141 – 208DisorderedSequence analysisAdd BLAST68
Regioni284 – 378DisorderedSequence analysisAdd BLAST95
Regioni409 – 441DisorderedSequence analysisAdd BLAST33
Regioni615 – 674DisorderedSequence analysisAdd BLAST60
Regioni1246 – 1270DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi145 – 159PolyampholyteSequence analysisAdd BLAST15
Compositional biasi304 – 320AcidicSequence analysisAdd BLAST17
Compositional biasi333 – 352PolyampholyteSequence analysisAdd BLAST20
Compositional biasi353 – 375AcidicSequence analysisAdd BLAST23
Compositional biasi615 – 663PolarSequence analysisAdd BLAST49

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, RepeatARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1082, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156002

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005790_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		H9GIS7

Identification of Orthologs from Complete Genome Data

More...OMAi		VCENQHG

TreeFam database of animal gene trees

More...TreeFami		TF106443

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR038035, EHMT1
IPR043550, EHMT1/EHMT2
IPR007728, Pre-SET_dom
IPR001214, SET_dom

The PANTHER Classification System

More...PANTHERi		PTHR46307, PTHR46307, 1 hit
PTHR46307:SF2, PTHR46307:SF2, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12796, Ank_2, 2 hits
PF05033, Pre-SET, 1 hit
PF00856, SET, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 6 hits
SM00468, PreSET, 1 hit
SM00317, SET, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 5 hits
PS50867, PRE_SET, 1 hit
PS50280, SET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9GIS7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAADESAIEK QVGEPKMAPD GETNGSCECS DTKGHPGAAK NTQDGAKVSQ 
        60         70         80         90        100
GDSAAKLSRI AENGLLERDG LAGKQNHIKA NDFTQTSVTG SNGYILSKQM 
       110        120        130        140        150
AQEAPARTNS GAFASLPGHA AKTLPAGKGR TLSAFAQAAL PTKHGDGAKD 
       160        170        180        190        200
GEGKKNTGAH GSMKVHRARK TLPKSPSDQN ASQDSKEAKT PKEDGNTDML 
       210        220        230        240        250
EFGNPASLPP ILGLHSSLPQ NQSYVATSKS QTDTFSLAFD SAASVSRKKK 
       260        270        280        290        300
RRMGTYSLVP KKKTKVLKQR TMTEMFKSIM QAASGVKGDK GDASLHVNGE 
       310        320        330        340        350
RLDMESEEED SDELEEDDER GTDNPAAFPA EDNRTAKEGD ADASNTIKEM 
       360        370        380        390        400
VDGESEEDQD FGESAEEEED GDESDLTTTT STIFYNESLL LSRQASAGVC 
       410        420        430        440        450
SWLPRAKTRA WSAQGRPRAD GAAGPEAYKP PLGSGDGAQP ESNMEYMEVS 
       460        470        480        490        500
LDSLDLRVKG ILSPQSEGLS NGPEAAEADS LQEVPLCSCR METPKSREIT 
       510        520        530        540        550
TLANNQCMAT ESIDKELSRC TNRVLKYELM RPSNKVQLLV LCEDHRGRMV 
       560        570        580        590        600
KHQCCPGCGF FCAAGTFMEC QPESSISHRF HQDCASQVKG TSYCPHCGEE 
       610        620        630        640        650
ASKAKEVTVA KADTTSTLPQ SYEQKKPSVS EGRADTTTGS GIVTQTSEEA 
       660        670        680        690        700
RLENSSSEGF DLAGTSSFPK PAPPGLPQGP VKETLESALI ALDSEKPKKL 
       710        720        730        740        750
RFHSKQLYFS ARQGELQKVL LMLVDGIDPN FKMEHQNKRT PLHAAAESGH 
       760        770        780        790        800
VDVCHMLIQA GANIDTCSQD QRTPLMEAAE NNHLETVKYL IKAGALVDPK 
       810        820        830        840        850
DAEGSTCLHL AAKKGHYDVV QYLLTNEEMD VNCQDDGGWT PMIWATEYKH 
       860        870        880        890        900
VELVKLLLAK GSDINIRDNE ENICLHWAAF SGCVDIAEIL LAAKCDLHAV 
       910        920        930        940        950
NIHGDSPLHI AARENRYECV VLFLSRGSDV TLKNKEGETP LQCSSLNSQV 
       960        970        980        990       1000
WVALQMNKTL KESSPDKPVQ LEKTLSNCGR DIARGYERIP IPCINAVDSE 
      1010       1020       1030       1040       1050
PCPTNYKYVS QNCVTSPMNI DRNITHLQYC VCIDDCSSSK CMCGQLSMRC 
      1060       1070       1080       1090       1100
WYDRDGRLLP EFNTAEPPLI FECNHACSCW RTCRNRVVQN GLRARLQLFR 
      1110       1120       1130       1140       1150
TRNMGWGVRT MQDIPLGTFV CEYVGELISD SEANVREEDC YLFDLGNKDR 
      1160       1170       1180       1190       1200
DVYCIDARFY GNISRFINHF CEPNLIAVRV FMSHQDLRFP RIAFFSSRHI 
      1210       1220       1230       1240       1250
QAGEEIGFDY GERFWNIKGK YFSCLCGSPK CRHSSAALAQ RLASPSLSPE 
      1260       1270
ASENRLPDTS STVAAASTPF
Length:1,270
Mass (Da):138,933
Last modified:May 16, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD02A51E8D5EA3787
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AAWZ02030207 Genomic DNA No translation available.
AAWZ02030208 Genomic DNA No translation available.
AAWZ02030209 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSACAT00000012354; ENSACAP00000012109; ENSACAG00000012200

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02030207 Genomic DNA No translation available.
AAWZ02030208 Genomic DNA No translation available.
AAWZ02030209 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000012109

Genome annotation databases

EnsembliENSACAT00000012354; ENSACAP00000012109; ENSACAG00000012200

Phylogenomic databases

eggNOGiKOG1082, Eukaryota
GeneTreeiENSGT00940000156002
HOGENOMiCLU_005790_3_0_1
InParanoidiH9GIS7
OMAiVCENQHG
TreeFamiTF106443

Gene expression databases

BgeeiENSACAG00000012200, Expressed in hemipenis and 15 other tissues

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR038035, EHMT1
IPR043550, EHMT1/EHMT2
IPR007728, Pre-SET_dom
IPR001214, SET_dom
PANTHERiPTHR46307, PTHR46307, 1 hit
PTHR46307:SF2, PTHR46307:SF2, 1 hit
PfamiView protein in Pfam
PF12796, Ank_2, 2 hits
PF05033, Pre-SET, 1 hit
PF00856, SET, 1 hit
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 6 hits
SM00468, PreSET, 1 hit
SM00317, SET, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 5 hits
PS50867, PRE_SET, 1 hit
PS50280, SET, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9GIS7_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9GIS7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: October 7, 2020
This is version 63 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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