UniProtKB - H9GIN6 (H9GIN6_ANOCA)
Protein
I-kappa-B kinase
Gene
CHUK
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Catalytic activityi
- [I-kappa-B protein]-L-serine + ATP = [I-kappa-B protein]-O-phospho-L-serine + ADP + H+ARBA annotationEC:2.7.11.10ARBA annotation
GO - Molecular functioni
- ATP binding Source: InterPro
- IkappaB kinase activity Source: UniProtKB-EC
- protein heterodimerization activity Source: Ensembl
- protein homodimerization activity Source: Ensembl
- protein serine/threonine kinase activity Source: GO_Central
- scaffold protein binding Source: Ensembl
- transferrin receptor binding Source: Ensembl
GO - Biological processi
- cellular response to cadmium ion Source: Ensembl
- cellular response to reactive oxygen species Source: Ensembl
- cellular response to virus Source: Ensembl
- negative regulation of NF-kappaB transcription factor activity Source: Ensembl
- NIK/NF-kappaB signaling Source: Ensembl
- peptidyl-serine phosphorylation Source: GO_Central
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
- positive regulation of interferon-alpha production Source: Ensembl
- positive regulation of NF-kappaB transcription factor activity Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- tumor necrosis factor-mediated signaling pathway Source: GO_Central
Keywordsi
Molecular function | TransferaseARBA annotation |
Ligand | Nucleotide-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CHUKImported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Cytosol
- IkappaB kinase complex Source: GO_Central
Nucleus
- nucleoplasm Source: Ensembl
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
CytoplasmARBA annotation, NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000011896, Expressed in forelimb bud and 14 other tissues |
Interactioni
GO - Molecular functioni
- protein heterodimerization activity Source: Ensembl
- protein homodimerization activity Source: Ensembl
- scaffold protein binding Source: Ensembl
- transferrin receptor binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000011973 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 235 | Protein kinaseInterPro annotationAdd BLAST | 235 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 391 – 411 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 561 – 581 | Sequence analysisAdd BLAST | 21 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG4250, Eukaryota |
GeneTreei | ENSGT00950000182937 |
HOGENOMi | CLU_000288_101_2_1 |
InParanoidi | H9GIN6 |
TreeFami | TF324269 |
Family and domain databases
InterProi | View protein in InterPro IPR041185, IKBKB_SDD IPR022007, IKKbetaNEMObind IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF18397, IKBKB_SDD, 1 hit PF12179, IKKbetaNEMObind, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM01239, IKKbetaNEMObind, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
H9GIN6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKKLNHPNIV KACDVPEEMN FLVNDVPLLA MEYCSKGDLR KLLNLPENCC
60 70 80 90 100
GLKESQILNL LSDIGSGIQY LHENRIIHRD LKPENIVLQD EGGKIIHKII
110 120 130 140 150
DLGYAKDLDQ GSLCTSFVGT LQYLAPELFD NKPYTASVDF WSFGTVVFEC
160 170 180 190 200
ITGFRPFLHN QQPFTWHDKI KKKDPKCIFA WEEMTGEVRF SAHLPNPNSL
210 220 230 240 250
CSIIVELMES WLQLMLNWDP QQRGGGRDPE TGNFRCFQLM DHLLNLKIVH
260 270 280 290 300
ILNMTSAKIL SFSLHPEESL HSLQSRIESE TGISTGNQDL LLEMGICLDP
310 320 330 340 350
RKPASQCVID GIRGWDSYMV YLFDKSKTIY EGPFASRSLS DCVNYIVQDS
360 370 380 390 400
KIQLPILQLR KIWAEAVYYV IGLKEDYSRL FQGQRAAMLS LLRYNANLTK
410 420 430 440 450
MKNNMVSASQ QLRAKLKFFQ QSIHLDLERY SDQMTYGISS EKMLKAWKEM
460 470 480 490 500
EEKALLCEQA GDIGYLDEQI MALHTEIVEL QRSPHARRQG DLMENLEQRA
510 520 530 540 550
IELYKQLKRR PPDHSYSDST EMVKIIVQTV QSQDWVLKEL FRHLSKLLDC
560 570 580 590 600
KQKIIDLLPK IEVALNNIKE ADNSVMQMQG KRQKEIWHLL KIACTQSSAK
610 620 630 640 650
SPVSSNGEVT SSVPACLSQT PSGNVLQPLS SMETSRNLVP FAHLIEENLS
660 670
YLHSFSTVIQ EATHGQSSSL KSLDWSWLN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02023806 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSACAT00000012217; ENSACAP00000011973; ENSACAG00000011896 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02023806 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000011973 |
Genome annotation databases
Ensembli | ENSACAT00000012217; ENSACAP00000011973; ENSACAG00000011896 |
Phylogenomic databases
eggNOGi | KOG4250, Eukaryota |
GeneTreei | ENSGT00950000182937 |
HOGENOMi | CLU_000288_101_2_1 |
InParanoidi | H9GIN6 |
TreeFami | TF324269 |
Gene expression databases
Bgeei | ENSACAG00000011896, Expressed in forelimb bud and 14 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR041185, IKBKB_SDD IPR022007, IKKbetaNEMObind IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF18397, IKBKB_SDD, 1 hit PF12179, IKKbetaNEMObind, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM01239, IKKbetaNEMObind, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H9GIN6_ANOCA | |
Accessioni | H9GIN6Primary (citable) accession number: H9GIN6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | June 26, 2013 | |
Last modified: | October 7, 2020 | |
This is version 51 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |