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UniProtKB - H9GIJ5 (H9GIJ5_ANOCA)

Entry version 54 (07 Oct 2020)
Sequence version 1 (16 May 2012)
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Protein

Acyl-coenzyme A oxidase

Gene

ACOX3

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FADARBA annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei160FADUniRule annotation1
Binding sitei199FAD; via amide nitrogenUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei452Proton acceptorUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseARBA annotation
LigandFADUniRule annotation, Flavoprotein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Acyl-coenzyme A oxidaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACOX3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSACAG00000012039, Expressed in liver and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		28377.ENSACAP00000011886

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini156 – 267Acyl-CoA_dh_MInterPro annotationAdd BLAST112
Domaini511 – 689ACOXInterPro annotationAdd BLAST179

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the acyl-CoA oxidase family.UniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0135, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159423

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014629_4_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		H9GIJ5

KEGG Orthology (KO)

More...KOi		K00232

Identification of Orthologs from Complete Genome Data

More...OMAi		GTEKHQK

Database of Orthologous Groups

More...OrthoDBi		226134at2759

TreeFam database of animal gene trees

More...TreeFami		TF314226

Family and domain databases

Conserved Domains Database

More...CDDi		cd01150, AXO, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR034171, ACO
IPR006091, Acyl-CoA_Oxase/DH_cen-dom
IPR012258, Acyl-CoA_oxidase
IPR002655, Acyl-CoA_oxidase_C
IPR036250, AcylCo_DH-like_C
IPR009100, AcylCoA_DH/oxidase_NM_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01756, ACOX, 1 hit
PF02770, Acyl-CoA_dh_M, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000168, Acyl-CoA_oxidase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47203, SSF47203, 2 hits
SSF56645, SSF56645, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9GIJ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSISNLEKA NSLLPDLPKG PLCAYRKKAS FNWKEMALFI EGEDLISFKN 
        60         70         80         90        100
EIFSTLENDP LFARLAGEEL SLEKYRELTF LRCRRLFEYD FLRLEEFVEK 
       110        120        130        140        150
PLKLVALITS LGMYDWSLGA KYLLNTQVFK GAVESGGFDR HADVINQNGT 
       160        170        180        190        200
MENFGCFALT ELSHGSNTKN MRTTARYDSS TQEFIIHSPD FEAAKFWVGN 
       210        220        230        240        250
MGKNATHAVV FAQLYTPDGQ CHGLHSFIVQ IRDPKTLLAM PGVLVGDIGR 
       260        270        280        290        300
KLGQNGLDNG FAMFHQVRIP KENLLNKTGD ITAAGTYTST FKDRKQRLGA 
       310        320        330        340        350
SLGSLSNGRV MIISMSLVNL KLAVSIAIRF SATRRQFGLT DDEEIPVLEY 
       360        370        380        390        400
QMQQWRLLPY LAAAYVLDHF SKTLFINSME FTIGLLMGDK SPQQAELGRE 
       410        420        430        440        450
IHALSTSGKP LASWLAQQGT QECREACGGH GYLAVNRLGD IRNDNDPNCT 
       460        470        480        490        500
YEGDNNVILQ QTSNYLLGWM NGRQQDKGPI ASPLGSVNFL EDYDRILCQK 
       510        520        530        540        550
FIVSDVQDCM DPSVPLRAFK WLVCYLLRES IQKLRNLEKA GYSEFEARNQ 
       560        570        580        590        600
SQVFHCRSLA IAFIEHVVLQ RYYDYVHSSK TPASLQPVLK QICSLYGLWS 
       610        620        630        640        650
LNKHMAVLYQ GGYVSGENAG RFVQDAILEL CSKLKQEAVA LVDVIAPPDF 
       660        670        680        690        700
ILNSPIGKVD GELYKNLWSS VLQGKKVLER PSWWLEFCNN KPVVGQLRSR 

M
Length:701
Mass (Da):78,995
Last modified:May 16, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i87454FF651A938DB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AAWZ02021218 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_003224212.1, XM_003224164.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSACAT00000012130; ENSACAP00000011886; ENSACAG00000012039

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100560789

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		acs:100560789

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02021218 Genomic DNA No translation available.
RefSeqiXP_003224212.1, XM_003224164.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000011886

Genome annotation databases

EnsembliENSACAT00000012130; ENSACAP00000011886; ENSACAG00000012039
GeneIDi100560789
KEGGiacs:100560789

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8310

Phylogenomic databases

eggNOGiKOG0135, Eukaryota
GeneTreeiENSGT00940000159423
HOGENOMiCLU_014629_4_2_1
InParanoidiH9GIJ5
KOiK00232
OMAiGTEKHQK
OrthoDBi226134at2759
TreeFamiTF314226

Gene expression databases

BgeeiENSACAG00000012039, Expressed in liver and 14 other tissues

Family and domain databases

CDDicd01150, AXO, 1 hit
InterProiView protein in InterPro
IPR034171, ACO
IPR006091, Acyl-CoA_Oxase/DH_cen-dom
IPR012258, Acyl-CoA_oxidase
IPR002655, Acyl-CoA_oxidase_C
IPR036250, AcylCo_DH-like_C
IPR009100, AcylCoA_DH/oxidase_NM_dom
PfamiView protein in Pfam
PF01756, ACOX, 1 hit
PF02770, Acyl-CoA_dh_M, 1 hit
PIRSFiPIRSF000168, Acyl-CoA_oxidase, 1 hit
SUPFAMiSSF47203, SSF47203, 2 hits
SSF56645, SSF56645, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9GIJ5_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9GIJ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: October 7, 2020
This is version 54 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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