UniProtKB - H9GIE0 (H9GIE0_ANOCA)
Protein
Bleomycin hydrolase
Gene
BLMH
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Catalytic activityi
- Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.UniRule annotationARBA annotation EC:3.4.22.40
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 73 | UniRule annotation | 1 | |
Active sitei | 371 | UniRule annotation | 1 | |
Active sitei | 395 | UniRule annotation | 1 |
GO - Molecular functioni
- cysteine-type endopeptidase activity Source: UniProtKB-UniRule
- cysteine-type peptidase activity Source: GO_Central
- identical protein binding Source: Ensembl
GO - Biological processi
- homocysteine catabolic process Source: GO_Central
- response to drug Source: Ensembl
- response to toxic substance Source: GO_Central
Keywordsi
Molecular function | Hydrolase, Protease, Thiol proteaseUniRule annotation |
Protein family/group databases
MEROPSi | C01.084 |
Names & Taxonomyi
Protein namesi | Recommended name: Bleomycin hydrolaseUniRule annotationARBA annotation (EC:3.4.22.40UniRule annotationARBA annotation) |
Gene namesi | Name:BLMHImported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Keywords - Cellular componenti
CytoplasmUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000011973, Expressed in hindlimb bud and 14 other tissues |
Interactioni
GO - Molecular functioni
- identical protein binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000011771 |
Family & Domainsi
Sequence similaritiesi
Belongs to the peptidase C1 family.UniRule annotation
Phylogenomic databases
eggNOGi | KOG4128, Eukaryota |
GeneTreei | ENSGT00390000001735 |
HOGENOMi | CLU_038600_0_0_1 |
InParanoidi | H9GIE0 |
OrthoDBi | 649145at2759 |
TreeFami | TF323372 |
Family and domain databases
CDDi | cd00585, Peptidase_C1B, 1 hit |
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR000169, Pept_cys_AS IPR004134, Peptidase_C1B |
PANTHERi | PTHR10363, PTHR10363, 1 hit |
Pfami | View protein in Pfam PF03051, Peptidase_C1_2, 1 hit |
PIRSFi | PIRSF005700, PepC, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00139, THIOL_PROTEASE_CYS, 1 hit |
i Sequence
Sequence statusi: Complete.
H9GIE0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSFPGLSLKK VEAFNLSLKA EPRYHLAQNV ATCADPLELC LERSVVQDTL
60 70 80 90 100
QVFQHAIPAE GKPVTNQKNS GRCWIFSCLN VMRLPFMKKL NIEEFEFSQA
110 120 130 140 150
HLFFWDKVER CYYFLDAFVK TAKNEPVDSR LVQFLLANPC NDGGQWDMLV
160 170 180 190 200
NLIEKHGVIP KKLFPESFTT EASRRMNEIL SYKMREYCHR LRNMVETGCN
210 220 230 240 250
EDELCAAKDA MIEEVFRVVT ICLGSPPKTF TWEYYDKEKN YHKIGPISPL
260 270 280 290 300
DFYKEHVKPL FNMESKVCLV NDPRPKNEYN RLYTVEYLGN MVGGRKTLYN
310 320 330 340 350
NQPIDLLKKV AAASIRDGEA VWFGCDVGKH FNSKLGINDM NIFNHELLFG
360 370 380 390 400
VSVKTMKKDE RLIFGDSMMT HAMVLTAFSE EEDKEGCFEK WRVENSWGEE
410 420 430 440 450
RGNKGYLIMT DEWFSEYVYE VVADRKHVPE EVLEVMHQEP IVLPAWDPMG
ALAK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02028413 Genomic DNA No translation available. |
RefSeqi | XP_003227226.1, XM_003227178.2 |
Genome annotation databases
Ensembli | ENSACAT00000012014; ENSACAP00000011771; ENSACAG00000011973 |
GeneIDi | 100564025 |
KEGGi | acs:100564025 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02028413 Genomic DNA No translation available. |
RefSeqi | XP_003227226.1, XM_003227178.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000011771 |
Protein family/group databases
MEROPSi | C01.084 |
Genome annotation databases
Ensembli | ENSACAT00000012014; ENSACAP00000011771; ENSACAG00000011973 |
GeneIDi | 100564025 |
KEGGi | acs:100564025 |
Organism-specific databases
CTDi | 642 |
Phylogenomic databases
eggNOGi | KOG4128, Eukaryota |
GeneTreei | ENSGT00390000001735 |
HOGENOMi | CLU_038600_0_0_1 |
InParanoidi | H9GIE0 |
OrthoDBi | 649145at2759 |
TreeFami | TF323372 |
Gene expression databases
Bgeei | ENSACAG00000011973, Expressed in hindlimb bud and 14 other tissues |
Family and domain databases
CDDi | cd00585, Peptidase_C1B, 1 hit |
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR000169, Pept_cys_AS IPR004134, Peptidase_C1B |
PANTHERi | PTHR10363, PTHR10363, 1 hit |
Pfami | View protein in Pfam PF03051, Peptidase_C1_2, 1 hit |
PIRSFi | PIRSF005700, PepC, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00139, THIOL_PROTEASE_CYS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H9GIE0_ANOCA | |
Accessioni | H9GIE0Primary (citable) accession number: H9GIE0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | June 26, 2013 | |
Last modified: | December 2, 2020 | |
This is version 53 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |