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Entry version 53 (07 Oct 2020)
Sequence version 1 (16 May 2012)
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Protein
Submitted name:

Uncharacterized protein

Gene

PHLPP1

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PHLPP1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000011864, Expressed in female gonad and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000011740

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 143PHInterPro annotationAdd BLAST101
Domaini682 – 929PPM-type phosphataseInterPro annotationAdd BLAST248

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni965 – 1006DisorderedSequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi968 – 1006PolarSequence analysisAdd BLAST39

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Leucine-rich repeatARBA annotation, RepeatARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0618, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158137

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003020_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H9GIC3

Identification of Orthologs from Complete Genome Data

More...
OMAi
LDICGYF

TreeFam database of animal gene trees

More...
TreeFami
TF315993

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00143, PP2Cc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit
3.60.40.10, 1 hit
3.80.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR036457, PPM-type_dom_sf
IPR001932, PPM-type_phosphatase_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00560, LRR_1, 1 hit
PF13855, LRR_8, 3 hits
PF00481, PP2C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369, LRR_TYP, 10 hits
SM00332, PP2Cc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81606, SSF81606, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450, LRR, 17 hits
PS50003, PH_DOMAIN, 1 hit
PS51746, PPM_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9GIC3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
HSFWFQIGYN KMGQSQESGL KKEIKLLAVS ISGKPHSIGN SERIQLSGMY
60 70 80 90 100
NVRKGKMHLP VNRWTRRQVI LCGTCLIVSS VKESQTGKMH VLPLIGGKVE
110 120 130 140 150
EVKKHQHCLA FSSSGPQSQS YYICFDTFTE YLRWLRQASK IASQRISSVD
160 170 180 190 200
LSCCSLEDLP ANLFYSQDLT HLNLKQNFLR LNPNSSSSRG LNELQRFSKL
210 220 230 240 250
RSLNLSNNHL GEFPLAVCSI PTLTELNVSC NALKNIPVAV GDMNNLQTFL
260 270 280 290 300
LDGNFLQSLP VELERMHQLS YLGLSFNEFT DIPEILEKLP AMDKLCMSGN
310 320 330 340 350
CLETLNLQTL RRMPHIKHID LRLNVIRRLV TDKADFLHHV TQLDLRDNKL
360 370 380 390 400
GELDATIFNN VEILHCERNQ LVTLKISGYL LKALYATANE LVHLDVYPVP
410 420 430 440 450
NYLTYMDVSR NHLESLPEWV CDSRKLEVLD LGHNQIRELP ARLFCNISLR
460 470 480 490 500
KLLAGHNQLA RLPERIERTH VEVLDVQHNL LTELPSNLLL KADSLRYLNA
510 520 530 540 550
SANKLEMLPP ATLSEETCSI LQELYLTNNH LTDKCVPLLT GHPHLKILHM
560 570 580 590 600
AYNRLQSFPA SKMAKLEELE EIDVSGNKLK SIPTTIMNCR RMHTVIAHSN
610 620 630 640 650
CIEVFPEVMQ LGEIKCVDLS CNELTEVTLP ENLPPKLQEL DLTGNPRLVL
660 670 680 690 700
DHKTLELLNN IRCFKIDQPS AGDASGAPAV WSHGYTEASG VKNKLCVAAL
710 720 730 740 750
SANNFCENRE ALYGVFDGDR NVEVPYLLQC TMSDILAEEL QKTKSEEEYM
760 770 780 790 800
INTFIVMQRK LGTAGQKLGG SAVLCHIKHD PIDPGGCFTL TSANVGKCQS
810 820 830 840 850
VLCRNGKPLP LSRSYMISCE EELRRIKQHK AIITEDGKVN GVTDSTRILG
860 870 880 890 900
YTFLHPSVIP RPHVQSITLT PQDEFFILGS KGLWDSLSIE EAVEAVRNVP
910 920 930 940 950
DALGAAKKLC TLAQSYGCND SLSAVVVQLN VTEDSFCCCE LNGVPPPSPG
960 970 980 990 1000
IFPQSVNVVI KDKPSDGLGM PSSSSGVASE ISSEISTSEM SSEVGSTASD
1010 1020 1030 1040 1050
EPPQVTMNEN SPAYPSEQRC MLHPVCLSNS FQRQLSSATF SSAFSDNGLD
1060 1070 1080 1090 1100
SDDEEPIEGV FSNGSRVEVE VDIHCGRAKE KQQLLTQAPM EASDEGIVIN
1110 1120 1130 1140 1150
TNEDEVCLLR KGDLSATGTI GRRRGNGSVA PQERSHNLIE VAADAPLRKT
1160 1170 1180 1190
GGYFAAPAQP DPDDQFIIPP ELEEEVKEII IMTRHYDQAS QNKVMRQ
Length:1,197
Mass (Da):133,107
Last modified:May 16, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC2C7793FD42DA0D1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAWZ02022555 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000011983; ENSACAP00000011740; ENSACAG00000011864

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02022555 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000011740

Genome annotation databases

EnsembliENSACAT00000011983; ENSACAP00000011740; ENSACAG00000011864

Phylogenomic databases

eggNOGiKOG0618, Eukaryota
GeneTreeiENSGT00940000158137
HOGENOMiCLU_003020_0_0_1
InParanoidiH9GIC3
OMAiLDICGYF
TreeFamiTF315993

Gene expression databases

BgeeiENSACAG00000011864, Expressed in female gonad and 14 other tissues

Family and domain databases

CDDicd00143, PP2Cc, 1 hit
Gene3Di2.30.29.30, 1 hit
3.60.40.10, 1 hit
3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR036457, PPM-type_dom_sf
IPR001932, PPM-type_phosphatase_dom
PfamiView protein in Pfam
PF00560, LRR_1, 1 hit
PF13855, LRR_8, 3 hits
PF00481, PP2C, 1 hit
SMARTiView protein in SMART
SM00369, LRR_TYP, 10 hits
SM00332, PP2Cc, 1 hit
SUPFAMiSSF81606, SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS51450, LRR, 17 hits
PS50003, PH_DOMAIN, 1 hit
PS51746, PPM_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9GIC3_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9GIC3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: October 7, 2020
This is version 53 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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