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Entry version 49 (07 Apr 2021)
Sequence version 2 (26 Jun 2013)
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Protein

Hyaluronoglucosaminidase

Gene

CEMIP

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.ARBA annotation EC:3.2.1.35

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidaseARBA annotation, Hydrolase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HyaluronoglucosaminidaseARBA annotation (EC:3.2.1.35ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CEMIPImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500362069922 – 1351HyaluronoglucosaminidaseSequence analysisAdd BLAST1330

Keywords - PTMi

GlycoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000011453, Expressed in female gonad and 10 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000011433

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 155G8InterPro annotationAdd BLAST123

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CEMIP family.ARBA annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QT0K, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153636

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005606_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H9GHY5

Identification of Orthologs from Complete Genome Data

More...
OMAi
SRGPWTK

Database of Orthologous Groups

More...
OrthoDBi
294134at2759

TreeFam database of animal gene trees

More...
TreeFami
TF316575

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13938, PANDER_like_TMEM2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019316, G8_domain
IPR039477, ILEI/PANDER_dom
IPR011050, Pectin_lyase_fold/virulence
IPR039473, TMEM2_PANDER-like
IPR025155, WxxW_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10162, G8, 1 hit
PF15711, ILEI, 2 hits
PF13330, Mucin2_WxxW, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01225, G8, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51126, SSF51126, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51484, G8, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9GHY5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLAVGFVSL IFVLPSLHAR AAPSCSDLDP ELELWDPGHD EDNRVNISHG
60 70 80 90 100
QKLLLASSAT VHSIHITNGG KLVIKDDTNP IVLRTRHILI ENDGAFYIGS
110 120 130 140 150
ESCPFQGNLT IILYGRADDD TPSDSYFGKK YIGVIGGGTL EIHGEKKLSW
160 170 180 190 200
TFLNKTLNPG GLQEGGYYFE RSWGHRGVIV HVIDPKTGAV VHSDRFDTYK
210 220 230 240 250
LKSESIRLVQ YLNTVDNGKI LSVAVNDEGS KNLDDSARKA MTKLGSKHFL
260 270 280 290 300
HLGFRHPWSF ITVKGRPSSS VEDHIEYQGR QGSAVAKVFK VFQAENGEHF
310 320 330 340 350
NVSSTSEWVQ DVAWTEWFEK PEKSKSKDGE KLSDFRAAHP EVCDHPLDIQ
360 370 380 390 400
ALTLDGAPLI VEVIYKNGRN YRFFCRGAGQ TSGGCHKYRV RFLCGKPVRP
410 420 430 440 450
KLTVTVDTNV NSTILRLADN VQSWKVGDRI VVASTDYSMH QAEEFQILPC
460 470 480 490 500
RACGRHEVKV AGKATYLHTG EVIDGVDMRA EVGLLSRNIV VMGETEKGCY
510 520 530 540 550
DYKTDLCSFF DFDTFGGHLK FGLGFKAVHL EGVELKYMGQ QLLGHYPVHF
560 570 580 590 600
HMAGDVDEEG GYHPPTYVKD ISIHHSFSRC VTVHGSNGLL IKDVVGYDAL
610 620 630 640 650
GHCFFTEDGP EVRNTFDHCL GLVVKPSTLL PSDRDTRMCK TITEDAYPGY
660 670 680 690 700
VPKPRQDCNA VSTFWLANPH NNLVNCAAAG SEETGFWFVL HHVPTGLSAG
710 720 730 740 750
MYPPGFSEHI PMGTFSNNRA HSNYRAGMII DNGVKTTPAS AKDKRPILTL
760 770 780 790 800
IAGRYSPHKD SDPLKPREPA IIRHFIAYKN QDHGAWLRGG DVWLEACQFS
810 820 830 840 850
DNGIGLTLAS GGTFPHDDGS KQEIKNSLFV GESGNTGTEM MDNHVWGPGG
860 870 880 890 900
LDHSGRTLPI GQNFPIRGIQ FYDGPINVQN CTFRKFAALE GRHTSALAFR
910 920 930 940 950
LNNAWQSCPN NNVTNIFFED VPITSRVFFG EPGPWFNGLD MDGDKTSVFH
960 970 980 990 1000
DVDGSVSEYP GSYLIKEDNW LIRHSDCIDV PDWRGSICSG QFAQVYIQAY
1010 1020 1030 1040 1050
KSANTRMKII KNDYYTHPLY LEGALSKSTH YQQYQPVITL QKGYTIHWDK
1060 1070 1080 1090 1100
TAPEELAIWL INFNKNDWIA IGFCYPRGTT FSILSDIHDR LTKKTNKTGT
1110 1120 1130 1140 1150
FYPALQMDKL EYRNPTKGYY YWDEETGLLF LKLRAQHEKE PFAFCSVKGC
1160 1170 1180 1190 1200
ERIRIKANIP RNPESSDCEA KAYPKHAEKP SIEVPMPKKL PSTISKRDHF
1210 1220 1230 1240 1250
VEVKIDSYKT RYFHLRDDFA YISVEGKKFH LSEDGIQVVV IDGHNGKIVD
1260 1270 1280 1290 1300
QTSFRNSILQ GIPAQIENYV NNIRDNSIVV ITSKGKLNTK SPWTKILDRL
1310 1320 1330 1340 1350
GAETGFKLKD KLAFVGYKGS FRPYWVKLKT DDEAVRIFQA LPVPVVKKMK

L
Length:1,351
Mass (Da):151,468
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC752B61BC6838D1B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAWZ02025196 Genomic DNA No translation available.
AAWZ02025197 Genomic DNA No translation available.
AAWZ02025198 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_008116745.1, XM_008118538.2
XP_008116746.1, XM_008118539.2
XP_008116747.1, XM_008118540.2
XP_008116748.1, XM_008118541.2
XP_008116749.1, XM_008118542.2
XP_008116750.1, XM_008118543.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000011672; ENSACAP00000011433; ENSACAG00000011453

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100554638

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
acs:100554638

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02025196 Genomic DNA No translation available.
AAWZ02025197 Genomic DNA No translation available.
AAWZ02025198 Genomic DNA No translation available.
RefSeqiXP_008116745.1, XM_008118538.2
XP_008116746.1, XM_008118539.2
XP_008116747.1, XM_008118540.2
XP_008116748.1, XM_008118541.2
XP_008116749.1, XM_008118542.2
XP_008116750.1, XM_008118543.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000011433

Genome annotation databases

EnsembliENSACAT00000011672; ENSACAP00000011433; ENSACAG00000011453
GeneIDi100554638
KEGGiacs:100554638

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57214

Phylogenomic databases

eggNOGiENOG502QT0K, Eukaryota
GeneTreeiENSGT00940000153636
HOGENOMiCLU_005606_1_0_1
InParanoidiH9GHY5
OMAiSRGPWTK
OrthoDBi294134at2759
TreeFamiTF316575

Gene expression databases

BgeeiENSACAG00000011453, Expressed in female gonad and 10 other tissues

Family and domain databases

CDDicd13938, PANDER_like_TMEM2, 1 hit
InterProiView protein in InterPro
IPR019316, G8_domain
IPR039477, ILEI/PANDER_dom
IPR011050, Pectin_lyase_fold/virulence
IPR039473, TMEM2_PANDER-like
IPR025155, WxxW_domain
PfamiView protein in Pfam
PF10162, G8, 1 hit
PF15711, ILEI, 2 hits
PF13330, Mucin2_WxxW, 2 hits
SMARTiView protein in SMART
SM01225, G8, 1 hit
SUPFAMiSSF51126, SSF51126, 1 hit
PROSITEiView protein in PROSITE
PS51484, G8, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9GHY5_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9GHY5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: June 26, 2013
Last modified: April 7, 2021
This is version 49 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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