UniProtKB - H9GHS2 (H9GHS2_ANOCA)
Protein
Follistatin-like protein 1
Gene
FSTL1
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- calcium ion binding Source: InterPro
- heparin binding Source: UniProtKB-KW
GO - Biological processi
- cell differentiation Source: GO_Central
- endothelial cell differentiation Source: Ensembl
- endothelial cell migration Source: Ensembl
- hematopoietic stem cell homeostasis Source: Ensembl
- multicellular organism development Source: GO_Central
- negative regulation of apoptotic process Source: Ensembl
- regulation of BMP signaling pathway Source: GO_Central
Keywordsi
Molecular function | Heparin-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Follistatin-like protein 1ARBA annotationAlternative name(s): Follistatin-related protein 1ARBA annotation |
Gene namesi | Name:FSTL1Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- extracellular region Source: UniProtKB-KW
Keywords - Cellular componenti
SecretedARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_5003621247 | 21 – 318 | Follistatin-like protein 1Sequence analysisAdd BLAST | 298 |
Keywords - PTMi
GlycoproteinARBA annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000011543, Expressed in embryonic post-anal tail and 14 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 56 – 103 | Kazal-likeInterPro annotationAdd BLAST | 48 | |
Domaini | 147 – 181 | EF-handInterPro annotationAdd BLAST | 35 | |
Domaini | 196 – 231 | EF-handInterPro annotationAdd BLAST | 36 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 293 – 313 | Sequence analysisAdd BLAST | 21 |
Keywords - Domaini
Coiled coilSequence analysis, SignalSequence analysisARBA annotationPhylogenomic databases
eggNOGi | ENOG502QQAG, Eukaryota |
GeneTreei | ENSGT00940000157784 |
HOGENOMi | CLU_038229_0_0_1 |
InParanoidi | H9GHS2 |
OrthoDBi | 1079836at2759 |
TreeFami | TF106409 |
Family and domain databases
Gene3Di | 3.90.290.10, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR002048, EF_hand_dom IPR003645, Fol_N IPR015369, Follistatin/Osteonectin_EGF IPR002350, Kazal_dom IPR036058, Kazal_dom_sf IPR036773, TB_dom_sf |
Pfami | View protein in Pfam PF09289, FOLN, 1 hit PF07648, Kazal_2, 1 hit |
SMARTi | View protein in SMART SM00274, FOLN, 1 hit SM00280, KAZAL, 1 hit |
SUPFAMi | SSF100895, SSF100895, 1 hit SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS50222, EF_HAND_2, 2 hits PS51465, KAZAL_2, 1 hit |
i Sequence
Sequence statusi: Complete.
H9GHS2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMWSSLVVVA FALLAGTVSG LQAEGEPVSK SKICANVFCG AGRECAVTEK
60 70 80 90 100
NEPTCLCIEK CKAHKRPVCG SNGKTYLNHC ELHRDACLTG SKIQVDYDGH
110 120 130 140 150
CKEKKPENSA ASPVVCYQTD RDELRRRVIQ WLETEIIPDG WFSKGNNYTE
160 170 180 190 200
ILDKYFKNFD DGDSRLDSSE FLKFVEQNET AVNITTYVDQ ETNKLLRGLC
210 220 230 240 250
VDALIELSDE NADWKLSFNE FLKCLNPTFN PPEKKCALED ETYEDGAETQ
260 270 280 290 300
VECNRCVCAC GNWVCTAMTC EGKNEKMSSQ GQHHEDTLTE EELARYVQEL
310
QKHQETSEKL KQMATKEI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02024957 Genomic DNA No translation available. |
RefSeqi | XP_003225849.1, XM_003225801.3 |
Genome annotation databases
Ensembli | ENSACAT00000011531; ENSACAP00000011294; ENSACAG00000011543 |
GeneIDi | 100565595 |
KEGGi | acs:100565595 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02024957 Genomic DNA No translation available. |
RefSeqi | XP_003225849.1, XM_003225801.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000011294 |
Genome annotation databases
Ensembli | ENSACAT00000011531; ENSACAP00000011294; ENSACAG00000011543 |
GeneIDi | 100565595 |
KEGGi | acs:100565595 |
Organism-specific databases
CTDi | 11167 |
Phylogenomic databases
eggNOGi | ENOG502QQAG, Eukaryota |
GeneTreei | ENSGT00940000157784 |
HOGENOMi | CLU_038229_0_0_1 |
InParanoidi | H9GHS2 |
OrthoDBi | 1079836at2759 |
TreeFami | TF106409 |
Gene expression databases
Bgeei | ENSACAG00000011543, Expressed in embryonic post-anal tail and 14 other tissues |
Family and domain databases
Gene3Di | 3.90.290.10, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR002048, EF_hand_dom IPR003645, Fol_N IPR015369, Follistatin/Osteonectin_EGF IPR002350, Kazal_dom IPR036058, Kazal_dom_sf IPR036773, TB_dom_sf |
Pfami | View protein in Pfam PF09289, FOLN, 1 hit PF07648, Kazal_2, 1 hit |
SMARTi | View protein in SMART SM00274, FOLN, 1 hit SM00280, KAZAL, 1 hit |
SUPFAMi | SSF100895, SSF100895, 1 hit SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS50222, EF_HAND_2, 2 hits PS51465, KAZAL_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H9GHS2_ANOCA | |
Accessioni | H9GHS2Primary (citable) accession number: H9GHS2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | June 26, 2013 | |
Last modified: | April 7, 2021 | |
This is version 53 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |