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Entry version 54 (02 Jun 2021)
Sequence version 2 (26 Jun 2013)
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Protein

Protein kinase domain-containing protein

Gene

PEAK1

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein kinase domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PEAK1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000011547, Expressed in forelimb bud and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000011290

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1343 – 1699Protein kinaseInterPro annotationAdd BLAST357

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni28 – 66DisorderedSequence analysisAdd BLAST39
Regioni336 – 367DisorderedSequence analysisAdd BLAST32
Regioni562 – 586DisorderedSequence analysisAdd BLAST25
Regioni716 – 755DisorderedSequence analysisAdd BLAST40
Regioni771 – 808DisorderedSequence analysisAdd BLAST38
Regioni835 – 875DisorderedSequence analysisAdd BLAST41
Regioni993 – 1046DisorderedSequence analysisAdd BLAST54
Regioni1271 – 1302DisorderedSequence analysisAdd BLAST32
Regioni1435 – 1480DisorderedSequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi38 – 60Polar residuesSequence analysisAdd BLAST23
Compositional biasi568 – 586Polar residuesSequence analysisAdd BLAST19
Compositional biasi771 – 788Polar residuesSequence analysisAdd BLAST18
Compositional biasi843 – 858Polar residuesSequence analysisAdd BLAST16
Compositional biasi993 – 1015Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi1016 – 1031Polar residuesSequence analysisAdd BLAST16
Compositional biasi1271 – 1292Polar residuesSequence analysisAdd BLAST22
Compositional biasi1458 – 1480Polar residuesSequence analysisAdd BLAST23

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QVUZ, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157591

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002882_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H9GHR9

Identification of Orthologs from Complete Genome Data

More...
OMAi
LPPSCMI

Database of Orthologous Groups

More...
OrthoDBi
49921at2759

TreeFam database of animal gene trees

More...
TreeFami
TF333340

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR008266, Tyr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9GHR9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSACNAFTEH VWKPGECKNC FKPKNLHQLP PAPEKPPVSN TNLKTNATHN
60 70 80 90 100
NNQRSRNTGN FRPPVAKKPT IAVKPTMMTV DGQVICGEVS SQDPCENKPV
110 120 130 140 150
TVGWNQNRAV VNKKTLNNNN NEEEIEGYSH AHRPFGNSDD VGKSPSNNNG
160 170 180 190 200
LTDVLKEIAG LDTSSPLTGN ELNSREAFLG RINNCYKRSL ERKMPPSCMM
210 220 230 240 250
GGMKDSQNKH VVLSGSTDVI SNEGGRFCYP ECSSGDESED DMFFSSIHED
260 270 280 290 300
HESWDESDEE LLAMEIRMRG QPRFANFRAN TLSPVRFCVD KKWNTVPLRN
310 320 330 340 350
KSLQRFCAVD YDDSYDEILN GYGDEPMILY GQESMQSMVS SDSMSPDSSL
360 370 380 390 400
TEESCSGTAS SSSQKLCNGV LSPSTPKDMK CIEEGYKGFC DDQQQKTASK
410 420 430 440 450
SPQNVTKTLE THKAVLALRL EEKDGKIAVQ SDNPECRSPS GMPAQATNSN
460 470 480 490 500
LVHSEEQAKP YRIVNMEQPI CKPYTVVDVS AAMTHECIEI QAKSVDSNSV
510 520 530 540 550
LSNSSDTPIA NAAPNSVSAG QINANLKKSS AVRYQEVWTS STSPRQKIPK
560 570 580 590 600
VELIANAPGP SVPVRKNIHK SAPTSPTSTN LSTKTIPVKS PNLSEIKFNS
610 620 630 640 650
YNNAGMPPFP IIIHDEPTYA RSSKNAIKVP IVINPNAYDN LAIYKSFLGT
660 670 680 690 700
SGELSVKDKT TSVISHTYEE IEAKSTASES LACKSAELFQ TKGSVNSTER
710 720 730 740 750
KLGSVAQKVQ EFNSCLGKGQ TSPKTPDHSS PTNAQRTLQD TGARTDNSQE
760 770 780 790 800
VSNGSRENAC TVLSQIVASI QPPQSPPEVS QSGPKSCSAE ELYSLPPDAD
810 820 830 840 850
TSKGAPVRPK SLFTLQSSAD AEAVQSTEVM SKEIPLKSPV THSPMLVSPS
860 870 880 890 900
HSSASPKSEQ APPFPPPRST SSPYHASKAL QRHFSNWTKP LSPVRSTEAE
910 920 930 940 950
SVLHSENRRA VDAKPKRWIS FKSFFRRRKT EDEEDREREK GKLVGLDGTV
960 970 980 990 1000
IHMLPPPPVQ RHNWFSESKT DASEKPSIVF MFKCEQAKME ARSDQQKAEL
1010 1020 1030 1040 1050
QRADAVAREE QSPEVSEENL SSCSSPPQVP REILSSPDPS GINASPEFRD
1060 1070 1080 1090 1100
MIKRLKKALR EFPLMGNCVS EYSGRVPDEQ TVENLSPRMP RSAFEHQGSS
1110 1120 1130 1140 1150
DNASLTRLSP PEMLQGEEEK EDMSDSSDIS ACSATYSNLG QSRATMIPPK
1160 1170 1180 1190 1200
HPRQPKGALD DAIAFGEISD LEMATSLHPT PPPLPKKTIL RAHTEPVPKE
1210 1220 1230 1240 1250
LQKQTLENSM CVMANPTYDI DTNWEASSAC SSVSSEFKAV DNESGDSLDR
1260 1270 1280 1290 1300
PPTKGLAICS STNSFSSLTA TSIKDRGSNS AESLSSRPAT HSKHSKAVQK
1310 1320 1330 1340 1350
PQRQALYRGI ENRGEVVSKI RSLHTDSLKK LSAKCEDLFM AGQKDQLRFG
1360 1370 1380 1390 1400
VDSWSDFRLT SDKPCCEAGD AVYYSASYAK DPLNNYAVKI CKSKAKESQQ
1410 1420 1430 1440 1450
YYHSLAIRQS LAIHFNIQQD CGHFLADVPV RLLPWEDPNS PEEEEEEQDD
1460 1470 1480 1490 1500
DVQKNKESPT CADVSQKDSS SPQGTISKQR SRVVVITREV PYLTMADFVQ
1510 1520 1530 1540 1550
ASSNRHDSNP DFYERQVCLL LLQLCSGLEH LKPYHITHCD LRLENLLLVD
1560 1570 1580 1590 1600
YRPGSSLLNF DSVEPTPMSA CPARLIVSNF SQAKQKTHMV DPEVLKDQSR
1610 1620 1630 1640 1650
LAPEIITATQ YKKCDEFQTG ILIYEMLHLP NPFDENPELK EKEYTRADLP
1660 1670 1680 1690 1700
KIPCRSLYSL GLQQLANCLL NPNPSERILI SEAKGVLQCL LWGPREDVFQ
1710 1720 1730 1740 1750
TFSASSRPAQ RETVLQNWLD IKRTLLMIKF AEKSLDRECK VNLEDWLCCQ
1760 1770
YLAFATTDSL SRVVKIMQRR
Length:1,770
Mass (Da):195,866
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i632831518C91A14A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAWZ02026435 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_008117391.1, XM_008119184.2
XP_016852312.1, XM_016996823.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000011527; ENSACAP00000011290; ENSACAG00000011547

Database of genes from NCBI RefSeq genomes

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GeneIDi
100566634

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
acs:100566634

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02026435 Genomic DNA No translation available.
RefSeqiXP_008117391.1, XM_008119184.2
XP_016852312.1, XM_016996823.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000011290

Genome annotation databases

EnsembliENSACAT00000011527; ENSACAP00000011290; ENSACAG00000011547
GeneIDi100566634
KEGGiacs:100566634

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79834

Phylogenomic databases

eggNOGiENOG502QVUZ, Eukaryota
GeneTreeiENSGT00940000157591
HOGENOMiCLU_002882_0_0_1
InParanoidiH9GHR9
OMAiLPPSCMI
OrthoDBi49921at2759
TreeFamiTF333340

Gene expression databases

BgeeiENSACAG00000011547, Expressed in forelimb bud and 14 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR008266, Tyr_kinase_AS
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9GHR9_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9GHR9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: June 26, 2013
Last modified: June 2, 2021
This is version 54 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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