UniProtKB - H9GHI8 (H9GHI8_ANOCA)
Protein
Submitted name:
Uncharacterized protein
Gene
TPX2
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
GO - Molecular functioni
- importin-alpha family protein binding Source: Ensembl
- microtubule binding Source: GO_Central
- protein kinase activator activity Source: GO_Central
- protein kinase binding Source: Ensembl
GO - Biological processi
- microtubule nucleation Source: Ensembl
- mitotic spindle assembly Source: GO_Central
- negative regulation of microtubule depolymerization Source: Ensembl
- regulation of mitotic spindle organization Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: Uncharacterized proteinImported |
Gene namesi | Name:TPX2Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Cytoskeleton
- spindle ARBA annotation
Cytoskeleton
- mitotic spindle Source: GO_Central
- nuclear microtubule Source: GO_Central
- spindle pole Source: Ensembl
Extracellular region or secreted
- intercellular bridge Source: Ensembl
Nucleus
- nuclear microtubule Source: GO_Central
- nucleoplasm Source: Ensembl
Other locations
- axon hillock Source: Ensembl
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, CytoskeletonARBA annotation, MicrotubuleARBA annotation, NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000011291, Expressed in hindlimb bud and 13 other tissues |
Interactioni
GO - Molecular functioni
- importin-alpha family protein binding Source: Ensembl
- microtubule binding Source: GO_Central
- protein kinase binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000011153 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 332 – 458 | TPX2_importinInterPro annotationAdd BLAST | 127 | |
Domaini | 514 – 561 | TPX2InterPro annotationAdd BLAST | 48 | |
Domaini | 623 – 703 | TPX2InterPro annotationAdd BLAST | 81 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 77 – 99 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 160 – 179 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 319 – 353 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 686 – 710 | DisorderedSequence analysisAdd BLAST | 25 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 180 – 207 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 511 – 531 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 623 – 671 | Sequence analysisAdd BLAST | 49 |
Sequence similaritiesi
Belongs to the TPX2 family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | ENOG502QVQS, Eukaryota |
GeneTreei | ENSGT00390000009842 |
HOGENOMi | CLU_022592_0_0_1 |
InParanoidi | H9GHI8 |
TreeFami | TF328997 |
Family and domain databases
InterProi | View protein in InterPro IPR027329, TPX2_C IPR027330, TPX2_central_dom IPR009675, TPX2_fam |
PANTHERi | PTHR14326, PTHR14326, 1 hit |
Pfami | View protein in Pfam PF06886, TPX2, 2 hits PF12214, TPX2_importin, 1 hit |
i Sequence
Sequence statusi: Complete.
H9GHI8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEDIYSFDV PECSNFKDMN DNDGVDAWFD LRMPKLSTPK GAFMQKTSAS
60 70 80 90 100
RTKLPHAFIT PIMKANDQCT ETVTEQTVSH NEEATPASGK TSGRAARRVS
110 120 130 140 150
ARRKSAQRRI MAKCQAERNA AVLASKQESP PPKKQRLSAQ REKLCEIPLN
160 170 180 190 200
RYVTPAKAKV PVASATPKRR NPSVKGKTTE ELEVEKMQKL QQEVVELRRK
210 220 230 240 250
NEESLKAAIA GPGQPMKMAI YVTKPVDFHF STDDRIKQHG ENQPASEYKE
260 270 280 290 300
VDFVAALRKH PPSPAQLPKR PTIPKPFNLS QGNKRKFDET HGEYVSLAQQ
310 320 330 340 350
VENFQKNTPP RYHLRSRKVN EGTNENRPLK PKLTIAKTPR LETRSRSRPA
360 370 380 390 400
TCKSTAELEA EEIAKLQQYK FKAQELNHRI LEGGPLLPKK PPTKEPTKPI
410 420 430 440 450
GFNLEIEKRI QDRENKKPQE EEHYEFHSRP CPIKILEDVV GVPEKKQVPV
460 470 480 490 500
TVPMSPAFAL KNRVNALARE EKKKEEVVPV IKAKPVPHFL VPFKPKTTEP
510 520 530 540 550
RQVEICPFSF DSRDKERLLQ KEKKIEELQK EEVPKFKAHQ LPHFDRITLP
560 570 580 590 600
EKKVKSPTKP EPFQLEIDKR GAMWQEMWQQ QLKEEMKRQK EAATFKAQPS
610 620 630 640 650
TVLKQEPFVP KKDCKTILAP EGFELATEER ARKRQEYEKA QAEKEALKAQ
660 670 680 690 700
LQEAARRAEE EREKKEVARL REEMVHKANP IRKYQRVEVK GSDLPPTIPK
710
SPKFSDRFQR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02032713 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSACAT00000011385; ENSACAP00000011153; ENSACAG00000011291 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02032713 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000011153 |
Genome annotation databases
Ensembli | ENSACAT00000011385; ENSACAP00000011153; ENSACAG00000011291 |
Phylogenomic databases
eggNOGi | ENOG502QVQS, Eukaryota |
GeneTreei | ENSGT00390000009842 |
HOGENOMi | CLU_022592_0_0_1 |
InParanoidi | H9GHI8 |
TreeFami | TF328997 |
Gene expression databases
Bgeei | ENSACAG00000011291, Expressed in hindlimb bud and 13 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR027329, TPX2_C IPR027330, TPX2_central_dom IPR009675, TPX2_fam |
PANTHERi | PTHR14326, PTHR14326, 1 hit |
Pfami | View protein in Pfam PF06886, TPX2, 2 hits PF12214, TPX2_importin, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H9GHI8_ANOCA | |
Accessioni | H9GHI8Primary (citable) accession number: H9GHI8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | June 26, 2013 | |
Last modified: | December 2, 2020 | |
This is version 44 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |