UniProtKB - H9GHC9 (H9GHC9_ANOCA)
Protein
DNA ligase
Gene
LIG1
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Catalytic activityi
- ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotationARBA annotation EC:6.5.1.1
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- DNA binding Source: InterPro
- DNA ligase (ATP) activity Source: GO_Central
GO - Biological processi
- DNA biosynthetic process Source: InterPro
- DNA ligation Source: GO_Central
- DNA recombination Source: UniProtKB-KW
- DNA repair Source: UniProtKB-KW
- lagging strand elongation Source: GO_Central
- Okazaki fragment processing involved in mitotic DNA replication Source: GO_Central
Keywordsi
Molecular function | LigaseUniRule annotationARBA annotation |
Biological process | DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotationARBA annotation |
Ligand | ATP-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:LIG1Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Mitochondrion
- mitochondrion Source: GO_Central
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSACAG00000011085, Expressed in hindlimb bud and 14 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 644 – 780 | DNA_LIGASE_A3InterPro annotationAdd BLAST | 137 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 265 | DisorderedSequence analysisAdd BLAST | 265 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 21 – 35 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 55 – 78 | PolyampholyteSequence analysisAdd BLAST | 24 | |
Compositional biasi | 79 – 115 | PolarSequence analysisAdd BLAST | 37 | |
Compositional biasi | 143 – 196 | PolyampholyteSequence analysisAdd BLAST | 54 | |
Compositional biasi | 232 – 246 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 247 – 265 | PolarSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0967, Eukaryota |
GeneTreei | ENSGT00940000157783 |
HOGENOMi | CLU_005138_0_2_1 |
InParanoidi | H9GHC9 |
OrthoDBi | 274264at2759 |
TreeFami | TF300342 |
Family and domain databases
Gene3Di | 1.10.3260.10, 1 hit |
InterProi | View protein in InterPro IPR000977, DNA_ligase_ATP-dep IPR012309, DNA_ligase_ATP-dep_C IPR012310, DNA_ligase_ATP-dep_cent IPR016059, DNA_ligase_ATP-dep_CS IPR012308, DNA_ligase_ATP-dep_N IPR036599, DNA_ligase_N_sf IPR012340, NA-bd_OB-fold |
Pfami | View protein in Pfam PF04679, DNA_ligase_A_C, 1 hit PF01068, DNA_ligase_A_M, 1 hit PF04675, DNA_ligase_A_N, 1 hit |
SUPFAMi | SSF117018, SSF117018, 1 hit SSF50249, SSF50249, 1 hit |
TIGRFAMsi | TIGR00574, dnl1, 1 hit |
PROSITEi | View protein in PROSITE PS00697, DNA_LIGASE_A1, 1 hit PS00333, DNA_LIGASE_A2, 1 hit PS50160, DNA_LIGASE_A3, 1 hit |
i Sequence
Sequence statusi: Complete.
H9GHC9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQSTIRSFFQ PLTQAKPGKG VAENSEEETT PKKKPVNSEK PVNGTALCAN
60 70 80 90 100
IPENSSAKKD EDNSVKSEGG KDTKSGESKQ ESICLPEQSK PVENNSPSTS
110 120 130 140 150
PAASNSPSPS SIPRRKTARK QVPKRKLEDE VNSYNNSQEV LSAKRQKGDD
160 170 180 190 200
DGDGSHGESD AKPMQVKEVK DKKEEDSELV EREEETEAEE KKMLTSSKLS
210 220 230 240 250
NKAISSFFAP RKTSVKADKK QTPGSEENVP PAKSHNEGKN HESNSVAKDS
260 270 280 290 300
PKASPTLEPS EYNSAKSNYH PIHDACWGSG QRVPYLAVAR TFEWIEQESA
310 320 330 340 350
RLKIIETLSN FFRSVIALSP EDLLPCVYLC LNRLGPAYEG LELGIGKTIL
360 370 380 390 400
MKALAQATGR QLDQIKAEAA EKGDLGLVAE SSRTTQGTMF APPKLGAGAV
410 420 430 440 450
FGKLQAIGRM MGSSSMNKKI DIIKSLFVAC RHSEARYIAR SLEGKLRIGL
460 470 480 490 500
AEQSVLSALA QAASLTPPGQ KFPPEILDAS KGKSAETRKS WLDERALIVK
510 520 530 540 550
QAFCELPNYD IIVPVLLEHG VESLPKHCKI TPGIPLKPML AHPTKGIGEV
560 570 580 590 600
LKRFEEAAFT CEYKYDGERA QIHILENGEV HIYSRNQENN TTKYPDIVSR
610 620 630 640 650
IPKVKKSTVE SCILDAEAVA WDPDSKQIQP FQVLTTRKRK DVDTEDIRVQ
660 670 680 690 700
VCVYAFDMLY LNGQSLVREP LTQRRTLLRD SFTEVEGQFL FATSMDTSNT
710 720 730 740 750
DEIAEFLERS IKDSCEGLMV KTLEVDATYE IAKRSHNWLK LKKDYLDGVG
760 770 780 790 800
DTLDLVVIGA YLGKGKRAGI YGGFLLACYD DESEEFQSIC KIGTGFTDED
810 820 830 840 850
LEKLHTSLKA HVIPQPRPYY RWGGTAEPDH WLETHHVWEV KCADLSISPV
860 870 880 890 900
HRAAAGLVDE EKGISLRFPR FLRLRDDKKP EEATTSAQVA ELYRKQQQIQ
910
NQQSVENGND DFY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02022076 Genomic DNA No translation available. |
RefSeqi | XP_003224638.1, XM_003224590.2 XP_008114707.1, XM_008116500.1 |
Genome annotation databases
Ensembli | ENSACAT00000011266; ENSACAP00000011038; ENSACAG00000011085 |
GeneIDi | 100565521 |
KEGGi | acs:100565521 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02022076 Genomic DNA No translation available. |
RefSeqi | XP_003224638.1, XM_003224590.2 XP_008114707.1, XM_008116500.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000011038 |
Genome annotation databases
Ensembli | ENSACAT00000011266; ENSACAP00000011038; ENSACAG00000011085 |
GeneIDi | 100565521 |
KEGGi | acs:100565521 |
Organism-specific databases
CTDi | 3978 |
Phylogenomic databases
eggNOGi | KOG0967, Eukaryota |
GeneTreei | ENSGT00940000157783 |
HOGENOMi | CLU_005138_0_2_1 |
InParanoidi | H9GHC9 |
OrthoDBi | 274264at2759 |
TreeFami | TF300342 |
Gene expression databases
Bgeei | ENSACAG00000011085, Expressed in hindlimb bud and 14 other tissues |
Family and domain databases
Gene3Di | 1.10.3260.10, 1 hit |
InterProi | View protein in InterPro IPR000977, DNA_ligase_ATP-dep IPR012309, DNA_ligase_ATP-dep_C IPR012310, DNA_ligase_ATP-dep_cent IPR016059, DNA_ligase_ATP-dep_CS IPR012308, DNA_ligase_ATP-dep_N IPR036599, DNA_ligase_N_sf IPR012340, NA-bd_OB-fold |
Pfami | View protein in Pfam PF04679, DNA_ligase_A_C, 1 hit PF01068, DNA_ligase_A_M, 1 hit PF04675, DNA_ligase_A_N, 1 hit |
SUPFAMi | SSF117018, SSF117018, 1 hit SSF50249, SSF50249, 1 hit |
TIGRFAMsi | TIGR00574, dnl1, 1 hit |
PROSITEi | View protein in PROSITE PS00697, DNA_LIGASE_A1, 1 hit PS00333, DNA_LIGASE_A2, 1 hit PS50160, DNA_LIGASE_A3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H9GHC9_ANOCA | |
Accessioni | H9GHC9Primary (citable) accession number: H9GHC9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | June 26, 2013 | |
Last modified: | December 2, 2020 | |
This is version 57 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |