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Entry version 51 (07 Oct 2020)
Sequence version 1 (16 May 2012)
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Protein

DNA helicase

Gene

RECQL4

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingARBA annotation, Metal-binding, Nucleotide-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA helicaseARBA annotation (EC:3.6.4.12ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RECQL4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000010589, Expressed in female gonad and 10 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000010438

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini411 – 425CCHC-typeInterPro annotationAdd BLAST15
Domaini524 – 702Helicase ATP-bindingInterPro annotationAdd BLAST179
Domaini724 – 904Helicase C-terminalInterPro annotationAdd BLAST181

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni226 – 330DisorderedSequence analysisAdd BLAST105
Regioni447 – 478DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi247 – 263PolyampholyteSequence analysisAdd BLAST17
Compositional biasi272 – 288BasicSequence analysisAdd BLAST17
Compositional biasi447 – 462PolarSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family. RecQ subfamily.ARBA annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0351, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160387

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001103_10_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H9GGL3

Identification of Orthologs from Complete Genome Data

More...
OMAi
ACLHSGM

TreeFam database of animal gene trees

More...
TreeFami
TF324150

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR004589, DNA_helicase_ATP-dep_RecQ
IPR021110, DNA_rep_checkpnt_protein
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR001878, Znf_CCHC
IPR036875, Znf_CCHC_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270, DEAD, 1 hit
PF11719, Drc1-Sld2, 1 hit
PF00271, Helicase_C, 1 hit
PF00098, zf-CCHC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SM00343, ZnF_C2HC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit
SSF57756, SSF57756, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00614, recQ_fam, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS50158, ZF_CCHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9GGL3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRCHEVKFL LKRWEASFFQ ENQRKPNKED MMEAPIEIKD LYREYKAMRK
60 70 80 90 100
GKEQCQSLSI SEDIIQKSTQ TPAAADKVAD SNCWGAHLNR SLEAPKVMPR
110 120 130 140 150
SQNTLQGSAQ YFGMKLKCNL GTAIKERPVN LRRSLTPRRK SITFVEKNTP
160 170 180 190 200
QMAKAASPIA EIDTLLPVAD AKARPLPLGK FQQLKQTVAK RLTSLDPGWL
210 220 230 240 250
DRCGVNAGAG LIQNIGNNCR QSVQREERAG GTSSKQVGVE LCEAESGVSD
260 270 280 290 300
PPKKRKRLQE GEDGTVSPKG SKSQGKRKRT KKPAGESRAK KQRKAGPKPG
310 320 330 340 350
VKNLLGEVME EDGPKAKWRS SIPPRKNNTF KPETEKLKCW KHQSFQQWSA
360 370 380 390 400
PKQGGNFVCL NLKKRSHVKG FALRGKHLRK QVWKQKWQKK GELFGGGGGG
410 420 430 440 450
GRILGRSSDT CFRCGEVGHW ASQCKGKEFT QRTEAPPETL QPFQVLKETK
460 470 480 490 500
NESSQGSPES QGQEGGVFLP MHRPTYEPPP PPKPIEPLYG LGPDAKVKET
510 520 530 540 550
PPEVFQALAE LGFTSFRAGQ ETAVMRILSG LSTLVVLSTG MGKSLCYQLP
560 570 580 590 600
AYLYSKRSTC ITLVISPLVS LMDDQVSGLP QHLKAVCIHS NMSKTQREAA
610 620 630 640 650
MEKVKAGKVH VLLLSPEALV GGGLSGSSCL PPADQLPPVA FACIDEAHCV
660 670 680 690 700
SEWSHNFRPC YLRLCKVLRE RLGVRCFLGL TATATLSTAR DVAHHLGISG
710 720 730 740 750
GEGIAVRSAA VPPNLHLSVS TDRDKDQALL SLLQGERFGG LDSIIIYCTR
760 770 780 790 800
REETARIAAL IRTCLQAKKS IRRPLKWIAD AYHAGLSSAE RRRVQNNFMS
810 820 830 840 850
GQLRVVAATV AFGMGLDKSD VRGVIHYNMP KNFESYVQEI GRAGRDGKPA
860 870 880 890 900
HCHLFLHPEG EDLHELRRHI YADTVDFFTV KRLVQKVFPR CKCRELHQKQ
910 920 930 940 950
QQLSKESGGE NPSSGAGQQR VCYRHERAIP IQPTVEALDF REEGIETLLC
960 970 980 990 1000
YLELHPQRWL EMLHPTFSSC RVICYGGPQQ LRTVAQRCPP LAVCLAQQRL
1010 1020 1030 1040 1050
QGISHTHASS VDFDVVALAD SMGWEVLPVK RALRQLQWDT RLQNGNQKGA
1060 1070 1080 1090 1100
PKSGVLVEFS ELSFYLRSYG DLTDEELDSV CEFLHRRVMD REKAALSQLQ
1110 1120 1130 1140 1150
VCFQAFQRVA FRSCASCCDD VGEERSNQLK TLLMEYFEKD VMLEEADYEH
1160 1170 1180 1190 1200
GDEGMDAKDL QDIKDWEDQI RADVRHFLSI RQDEKFSGRA VARILHGIGS
1210 1220 1230
PCFPAQIYGR DRRFWRKYIH FDFNRIMRLA TEEIIHWNR
Length:1,239
Mass (Da):138,989
Last modified:May 16, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i383959DE08451DEA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAWZ02031315 Genomic DNA No translation available.
AAWZ02031316 Genomic DNA No translation available.
AAWZ02031317 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000010652; ENSACAP00000010438; ENSACAG00000010589

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02031315 Genomic DNA No translation available.
AAWZ02031316 Genomic DNA No translation available.
AAWZ02031317 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000010438

Genome annotation databases

EnsembliENSACAT00000010652; ENSACAP00000010438; ENSACAG00000010589

Phylogenomic databases

eggNOGiKOG0351, Eukaryota
GeneTreeiENSGT00940000160387
HOGENOMiCLU_001103_10_0_1
InParanoidiH9GGL3
OMAiACLHSGM
TreeFamiTF324150

Gene expression databases

BgeeiENSACAG00000010589, Expressed in female gonad and 10 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR004589, DNA_helicase_ATP-dep_RecQ
IPR021110, DNA_rep_checkpnt_protein
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR001878, Znf_CCHC
IPR036875, Znf_CCHC_sf
PfamiView protein in Pfam
PF00270, DEAD, 1 hit
PF11719, Drc1-Sld2, 1 hit
PF00271, Helicase_C, 1 hit
PF00098, zf-CCHC, 1 hit
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SM00343, ZnF_C2HC, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
SSF57756, SSF57756, 1 hit
TIGRFAMsiTIGR00614, recQ_fam, 1 hit
PROSITEiView protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS50158, ZF_CCHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9GGL3_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9GGL3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: October 7, 2020
This is version 51 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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