UniProtKB - H9GG01 (H9GG01_ANOCA)
Protein
Submitted name:
STIP1 homology and U-box containing protein 1
Gene
STUB1
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
GO - Molecular functioni
- chaperone binding Source: GO_Central
- G protein-coupled receptor binding Source: Ensembl
- Hsp70 protein binding Source: Ensembl
- Hsp90 protein binding Source: Ensembl
- kinase binding Source: Ensembl
- misfolded protein binding Source: Ensembl
- protein homodimerization activity Source: Ensembl
- SMAD binding Source: Ensembl
- TPR domain binding Source: Ensembl
- ubiquitin protein ligase activity Source: GO_Central
- ubiquitin protein ligase binding Source: Ensembl
GO - Biological processi
- cellular response to misfolded protein Source: GO_Central
- negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
- positive regulation of chaperone-mediated protein complex assembly Source: Ensembl
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
- positive regulation of protein ubiquitination Source: Ensembl
- positive regulation of proteolysis Source: GO_Central
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
- protein autoubiquitination Source: Ensembl
- protein K63-linked ubiquitination Source: Ensembl
- protein polyubiquitination Source: GO_Central
- protein quality control for misfolded or incompletely synthesized proteins Source: GO_Central
- regulation of glucocorticoid metabolic process Source: Ensembl
- regulation of protein stability Source: Ensembl
- ubiquitin-dependent ERAD pathway Source: Ensembl
- ubiquitin-dependent SMAD protein catabolic process Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: STIP1 homology and U-box containing protein 1Imported |
Gene namesi | Name:STUB1Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Cytosol
- cytosol Source: Ensembl
Endoplasmic reticulum
- endoplasmic reticulum Source: Ensembl
Nucleus
- nuclear inclusion body Source: Ensembl
- nucleoplasm Source: Ensembl
Other locations
- chaperone complex Source: Ensembl
- cytoplasm Source: GO_Central
- ubiquitin ligase complex Source: Ensembl
- Z disc Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSACAG00000010058, Expressed in embryonic post-anal tail and 14 other tissues |
Interactioni
GO - Molecular functioni
- chaperone binding Source: GO_Central
- G protein-coupled receptor binding Source: Ensembl
- Hsp70 protein binding Source: Ensembl
- Hsp90 protein binding Source: Ensembl
- kinase binding Source: Ensembl
- misfolded protein binding Source: Ensembl
- protein homodimerization activity Source: Ensembl
- SMAD binding Source: Ensembl
- TPR domain binding Source: Ensembl
- ubiquitin protein ligase binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000009902 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 30 – 131 | TPR_REGIONInterPro annotationAdd BLAST | 102 | |
Repeati | 64 – 97 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 98 – 131 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Domaini | 231 – 304 | U-boxInterPro annotationAdd BLAST | 74 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 15 – 38 | DisorderedSequence analysisAdd BLAST | 24 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 104 – 131 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 174 – 194 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 202 – 222 | Sequence analysisAdd BLAST | 21 |
Keywords - Domaini
Coiled coilSequence analysis, TPR repeatPROSITE-ProRule annotationPhylogenomic databases
eggNOGi | KOG4642, Eukaryota |
GeneTreei | ENSGT00930000151045 |
HOGENOMi | CLU_056455_1_0_1 |
InParanoidi | H9GG01 |
OMAi | EVPDWAI |
TreeFami | TF313937 |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR041312, CHIP_TPR_N IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat IPR003613, Ubox_domain IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF18391, CHIP_TPR_N, 1 hit PF04564, U-box, 1 hit |
SMARTi | View protein in SMART SM00028, TPR, 2 hits SM00504, Ubox, 1 hit |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50005, TPR, 2 hits PS50293, TPR_REGION, 1 hit PS51698, U_BOX, 1 hit |
i Sequence
Sequence statusi: Complete.
H9GG01-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
LLGLLLRLPG ARAGCGGEAR PGASGPSGRE GGSKEQGNRL FVGRKYPEAA
60 70 80 90 100
ACYGRSINRN PLVAVYYTNR ALCYLKMQQH DKALADCKHA LELDSQSVKA
110 120 130 140 150
HFFLGQCQME MENYDEAIAN LQRAYNLAKE QRLNFGDDIP SALRIAKKKR
160 170 180 190 200
WNNIEEKRIN QENELHSYLT KLIMAEKERE LDECRRAQEE ENVDENRSRA
210 220 230 240 250
QLANIEAKHE KYLADMDELF SQVDEKRKKR DIPDYLCGKI SFELMRECIT
260 270 280 290 300
PSGITYDRKD IEEHLQRVGH FDPVTRSPLT QDQLIPNLAM KEVIDAFISE
NGWVEDY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02034801 Genomic DNA No translation available. AAWZ02034802 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSACAT00000010105; ENSACAP00000009902; ENSACAG00000010058 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02034801 Genomic DNA No translation available. AAWZ02034802 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000009902 |
Genome annotation databases
Ensembli | ENSACAT00000010105; ENSACAP00000009902; ENSACAG00000010058 |
Phylogenomic databases
eggNOGi | KOG4642, Eukaryota |
GeneTreei | ENSGT00930000151045 |
HOGENOMi | CLU_056455_1_0_1 |
InParanoidi | H9GG01 |
OMAi | EVPDWAI |
TreeFami | TF313937 |
Gene expression databases
Bgeei | ENSACAG00000010058, Expressed in embryonic post-anal tail and 14 other tissues |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR041312, CHIP_TPR_N IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat IPR003613, Ubox_domain IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF18391, CHIP_TPR_N, 1 hit PF04564, U-box, 1 hit |
SMARTi | View protein in SMART SM00028, TPR, 2 hits SM00504, Ubox, 1 hit |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50005, TPR, 2 hits PS50293, TPR_REGION, 1 hit PS51698, U_BOX, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H9GG01_ANOCA | |
Accessioni | H9GG01Primary (citable) accession number: H9GG01 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | May 16, 2012 | |
Last modified: | August 12, 2020 | |
This is version 53 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |