UniProtKB - H9GFM4 (H9GFM4_ANOCA)
Protein
WD_REPEATS_REGION domain-containing protein
Gene
WDR70
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
GO - Molecular functioni
- enzyme binding Source: Ensembl
GO - Biological processi
- regulation of DNA double-strand break processing Source: GO_Central
- regulation of histone H2B conserved C-terminal lysine ubiquitination Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: WD_REPEATS_REGION domain-containing proteinInterPro annotation |
Gene namesi | Name:WDR70Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Nucleus
- nucleus Source: GO_Central
Other locations
- site of double-strand break Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSACAG00000009770, Expressed in forelimb bud and 14 other tissues |
Interactioni
GO - Molecular functioni
- enzyme binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000009608 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 170 – 407 | WD_REPEATS_REGIONInterPro annotationAdd BLAST | 238 | |
Repeati | 170 – 202 | WDPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 271 – 313 | WDPROSITE-ProRule annotationAdd BLAST | 43 | |
Repeati | 328 – 352 | WDPROSITE-ProRule annotationAdd BLAST | 25 | |
Repeati | 366 – 407 | WDPROSITE-ProRule annotationAdd BLAST | 42 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 23 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 61 – 162 | DisorderedSequence analysisAdd BLAST | 102 | |
Regioni | 533 – 574 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 625 – 646 | DisorderedSequence analysisAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 76 – 95 | PolarSequence analysisAdd BLAST | 20 | |
Compositional biasi | 139 – 153 | AcidicSequence analysisAdd BLAST | 15 | |
Compositional biasi | 533 – 554 | PolyampholyteSequence analysisAdd BLAST | 22 |
Keywords - Domaini
RepeatARBA annotation, WD repeatPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG0772, Eukaryota |
GeneTreei | ENSGT00390000015433 |
HOGENOMi | CLU_014033_1_2_1 |
InParanoidi | H9GFM4 |
OrthoDBi | 729650at2759 |
TreeFami | TF105809 |
Family and domain databases
Gene3Di | 2.130.10.10, 2 hits |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 2 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 6 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 4 hits PS50294, WD_REPEATS_REGION, 1 hit |
i Sequence
Sequence statusi: Complete.
H9GFM4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEQPGAESDA DPVGGADPQL AATMGFSGFG KKARTFDFNA MFEQTRRTAV
60 70 80 90 100
ERSRKILEER EKAAAEKEKE LDNQPGVGNL SATAPCPVGR TSSRDSSSSE
110 120 130 140 150
SEDSSDEELI GPPPPAQGTL EDSDDELIGP PLPPGYKDSD DEDEGDDNDN
160 170 180 190 200
IQEEDEDPVR KIPDSHEITL HHGTKTVSAL GLDPSGARLI TGGYDYDVRF
210 220 230 240 250
WDFAGMDASL QAFRSLQPCE CHQIKSLQYS STGDVILVVA GNAQAKVLDR
260 270 280 290 300
DGFPVMECVK GDQYIVDMAN TKGHTAMLNS GCWHPKIKEE FLTCSNDGTV
310 320 330 340 350
RTWDVTNDKK HKGVFKPRSA QGKRVIPTSC TYSRDGKLIA AGSQDGSIQI
360 370 380 390 400
WDRNMNVHTK FHCRHAHAPG SDTSCLTFSY DGTILASRGG DDTLKTWDMR
410 420 430 440 450
KFKTPLNSVA GLPSFFPMTD CCFSPDDKLL VTGTSVKKGH GNGKLLFFER
460 470 480 490 500
ETFKKVYEID VTDASVVRCL WHPKLNQIMV GTGNGLAKVY YDPFKSQRGA
510 520 530 540 550
KLCVVKTKRK ERQAETLTQD YIITPHALPM FREPRQRSTR KQLEKDRLDP
560 570 580 590 600
MKSHKPEPPV AGPGRGGRVG THGGTLSSYI VKNIALDKTD DSNPREAILR
610 620 630 640
HAKEAEENPY WVAPAYSKTQ PKTVFAEVES DEDEPDDKPE WKKRKI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02021477 Genomic DNA No translation available. AAWZ02021478 Genomic DNA No translation available. |
RefSeqi | XP_008114303.1, XM_008116096.2 |
Genome annotation databases
Ensembli | ENSACAT00000009805; ENSACAP00000009608; ENSACAG00000009770 |
GeneIDi | 100563229 |
KEGGi | acs:100563229 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02021477 Genomic DNA No translation available. AAWZ02021478 Genomic DNA No translation available. |
RefSeqi | XP_008114303.1, XM_008116096.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000009608 |
Genome annotation databases
Ensembli | ENSACAT00000009805; ENSACAP00000009608; ENSACAG00000009770 |
GeneIDi | 100563229 |
KEGGi | acs:100563229 |
Organism-specific databases
CTDi | 55100 |
Phylogenomic databases
eggNOGi | KOG0772, Eukaryota |
GeneTreei | ENSGT00390000015433 |
HOGENOMi | CLU_014033_1_2_1 |
InParanoidi | H9GFM4 |
OrthoDBi | 729650at2759 |
TreeFami | TF105809 |
Gene expression databases
Bgeei | ENSACAG00000009770, Expressed in forelimb bud and 14 other tissues |
Family and domain databases
Gene3Di | 2.130.10.10, 2 hits |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 2 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 6 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 4 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H9GFM4_ANOCA | |
Accessioni | H9GFM4Primary (citable) accession number: H9GFM4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | June 26, 2013 | |
Last modified: | August 12, 2020 | |
This is version 47 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |