UniProtKB - H9GFJ6 (H9GFJ6_ANOCA)
Protein
Pescadillo homolog
Gene
PES1
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.UniRule annotation
GO - Molecular functioni
- ribonucleoprotein complex binding Source: UniProtKB-UniRule
- RNA binding Source: GO_Central
GO - Biological processi
- cell population proliferation Source: Ensembl
- maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: UniProtKB-UniRule
- maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
- nucleolus organization Source: Ensembl
- protein localization to organelle Source: Ensembl
- regulation of cell cycle Source: Ensembl
Keywordsi
Biological process | Ribosome biogenesisUniRule annotationARBA annotation, rRNA processingUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Pescadillo homologUniRule annotation |
Gene namesi | Name:PES1UniRule annotationImported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Nucleus
- nucleolus UniRule annotation
- nucleoplasm UniRule annotation
Cytosol
- cytosol Source: Ensembl
Nucleus
- nucleoplasm Source: UniProtKB-SubCell
- PeBoW complex Source: GO_Central
Other locations
- condensed chromosome Source: Ensembl
- preribosome, large subunit precursor Source: UniProtKB-UniRule
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000009723, Expressed in hemipenis and 13 other tissues |
Interactioni
Subunit structurei
Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
UniRule annotationProtein-protein interaction databases
STRINGi | 28377.ENSACAP00000009549 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 324 – 417 | BRCTInterPro annotationAdd BLAST | 94 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 292 – 319 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 450 – 513 | DisorderedSequence analysisAdd BLAST | 64 | |
Regioni | 563 – 586 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 294 – 308 | AcidicSequence analysisAdd BLAST | 15 | |
Compositional biasi | 456 – 485 | AcidicSequence analysisAdd BLAST | 30 | |
Compositional biasi | 563 – 577 | PolyampholyteSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the pescadillo family.UniRule annotation
Phylogenomic databases
eggNOGi | KOG2481, Eukaryota |
GeneTreei | ENSGT00390000002626 |
InParanoidi | H9GFJ6 |
OMAi | VDFKVMS |
TreeFami | TF300671 |
Family and domain databases
Gene3Di | 3.40.50.10190, 1 hit |
HAMAPi | MF_03028, Pescadillo, 1 hit |
InterProi | View protein in InterPro IPR001357, BRCT_dom IPR036420, BRCT_dom_sf IPR010613, PES |
PANTHERi | PTHR12221, PTHR12221, 1 hit |
Pfami | View protein in Pfam PF16589, BRCT_2, 1 hit PF06732, Pescadillo_N, 1 hit |
SMARTi | View protein in SMART SM00292, BRCT, 1 hit |
SUPFAMi | SSF52113, SSF52113, 1 hit |
PROSITEi | View protein in PROSITE PS50172, BRCT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
H9GFJ6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGGLEKKKLK RHSQADTNYV ELAETLGDMA LSFPRRLCIL KGIYPHEPKH
60 70 80 90 100
KKKVNKGSTA PRTFYLIKDI KFLLHEPIVH KFREYKVFVR KLRKAYGKSE
110 120 130 140 150
WNAVQRLKDN KPGYKLDHIV KERYPTFIDA LRDVDDALSM CFLFATFPRT
160 170 180 190 200
GKCHVQTIQL CRRLTVEFLN YVIASRALRK VFLSIKGIYY QAEVMGQLVT
210 220 230 240 250
WITPYAFSHN HPTDVDYRVM ATFTEFYTTL LGFVNFRLYQ SLNLHYPPKI
260 270 280 290 300
EGSPSVKQKP EEEELYALDS ESYLEKLSAL SASLARVVAP SPEEEEAQVD
310 320 330 340 350
EFPVEGESAE EEDARKKEQE ALEKQRKLFE GLRFFLNREV PREPLAFVIR
360 370 380 390 400
CFGGEVSWDR SVCIGATYDV TDPKITHQIV DRPGLEQQVI GRYYLQPQWV
410 420 430 440 450
FDSVNAKLCL PVGDYFPGVA LPPHLSPFVS EKEGDYIPPE KLKLLALQRG
460 470 480 490 500
DNPGEESESG EEEEEGEGAT ESEEEEEEEE EDSEKEDEGR LKKMEAQRSQ
510 520 530 540 550
SKSLPVKVTA GKVLKEDKER LAQEEQSEEK RLAIMMMKKR EKYLYQKIMF
560 570 580
GKRRKIREVN KLAEKRKAHD AAVKSEKKKG KKARRE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketR4G9W0 | R4G9W0_ANOCA | Pescadillo homolog | PES1 | 558 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02027451 Genomic DNA No translation available. AAWZ02027452 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSACAT00000009746; ENSACAP00000009549; ENSACAG00000009723 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAWZ02027451 Genomic DNA No translation available. AAWZ02027452 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000009549 |
Genome annotation databases
Ensembli | ENSACAT00000009746; ENSACAP00000009549; ENSACAG00000009723 |
Phylogenomic databases
eggNOGi | KOG2481, Eukaryota |
GeneTreei | ENSGT00390000002626 |
InParanoidi | H9GFJ6 |
OMAi | VDFKVMS |
TreeFami | TF300671 |
Gene expression databases
Bgeei | ENSACAG00000009723, Expressed in hemipenis and 13 other tissues |
Family and domain databases
Gene3Di | 3.40.50.10190, 1 hit |
HAMAPi | MF_03028, Pescadillo, 1 hit |
InterProi | View protein in InterPro IPR001357, BRCT_dom IPR036420, BRCT_dom_sf IPR010613, PES |
PANTHERi | PTHR12221, PTHR12221, 1 hit |
Pfami | View protein in Pfam PF16589, BRCT_2, 1 hit PF06732, Pescadillo_N, 1 hit |
SMARTi | View protein in SMART SM00292, BRCT, 1 hit |
SUPFAMi | SSF52113, SSF52113, 1 hit |
PROSITEi | View protein in PROSITE PS50172, BRCT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H9GFJ6_ANOCA | |
Accessioni | H9GFJ6Primary (citable) accession number: H9GFJ6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | May 16, 2012 | |
Last modified: | December 2, 2020 | |
This is version 56 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |