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UniProtKB - H9GFF6 (H9GFF6_ANOCA)
Protein
Alkylated DNA repair protein alkB homolog 5
Gene
ALKBH5
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Cofactori
Fe2+ARBA annotation
GO - Molecular functioni
- mRNA N6-methyladenosine dioxygenase activity Source: Ensembl
- oxidative RNA demethylase activity Source: GO_Central
GO - Biological processi
- mRNA export from nucleus Source: GO_Central
- mRNA processing Source: GO_Central
- oxidative single-stranded RNA demethylation Source: GO_Central
- regulation of mRNA stability Source: Ensembl
- response to hypoxia Source: Ensembl
- spermatogenesis Source: Ensembl
Keywordsi
Ligand | Metal-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Alkylated DNA repair protein alkB homolog 5ARBA annotationAlternative name(s): Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5ARBA annotation RNA demethylase ALKBH5ARBA annotation |
Gene namesi | Name:ALKBH5Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus speckle ARBA annotation
Cytosol
- cytosol Source: Ensembl
Golgi apparatus
- Golgi apparatus Source: Ensembl
Nucleus
- nuclear speck Source: UniProtKB-SubCell
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000009646, Expressed in skeletal muscle tissue and 13 other tissues |
Interactioni
Subunit structurei
Monomer.
ARBA annotationProtein-protein interaction databases
STRINGi | 28377.ENSACAP00000009439 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 136 – 259 | 2OG-FeII_Oxy_2InterPro annotationAdd BLAST | 124 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 16 – 71 | DisorderedSequence analysisAdd BLAST | 56 | |
Regioni | 285 – 379 | DisorderedSequence analysisAdd BLAST | 95 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 34 – 71 | Basic and acidic residuesSequence analysisAdd BLAST | 38 | |
Compositional biasi | 295 – 354 | Basic and acidic residuesSequence analysisAdd BLAST | 60 |
Phylogenomic databases
eggNOGi | KOG4176, Eukaryota |
GeneTreei | ENSGT00390000009298 |
HOGENOMi | CLU_047472_1_0_1 |
InParanoidi | H9GFF6 |
OMAi | ENYWRRD |
OrthoDBi | 722070at2759 |
TreeFami | TF329212 |
Family and domain databases
Gene3Di | 2.60.120.590, 1 hit |
InterProi | View protein in InterPro IPR027450, AlkB-like IPR037151, AlkB-like_sf IPR032860, ALKBH5 |
PANTHERi | PTHR32074, PTHR32074, 2 hits |
Pfami | View protein in Pfam PF13532, 2OG-FeII_Oxy_2, 1 hit |
i Sequence
Sequence statusi: Complete.
H9GFF6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGSSYTDLR EKLKSMMPYR DGYKGSSLRD PEEPPYGSTD RKRKYHEDSE
60 70 80 90 100
SEPSDYEERQ REEEEAQKVK SGIRQLRLFS PEECAKIEAR IDEVVSRAEK
110 120 130 140 150
GLYKEHTVDR APLRNKYFFG EGYTYGSQLQ RRGPGQERLY PRGEVDTIPE
160 170 180 190 200
WVHDLVIRKL VEHRVIPEGF VNSAVINDYQ PGGCIVSHVD PIHIFERPIV
210 220 230 240 250
SVSFFSDSAL CFGCKFQFKP IRVSEPVFFL PVRRGSVTVL SGYAADEITH
260 270 280 290 300
CIRPQDIKER RAVIILRKTR LDAPRLEMRT LMPGYASDRL SGSNRDPILK
310 320 330 340 350
PKRSHRKADP DAAHRPRILE MDKEENRRSV LLPKHRRRSH FSSENYWRKS
360 370
HGEDFEEEEE EEEEEEDGSP ARKVKMRRH
Sequence databases
RefSeqi | XP_003228347.1, XM_003228299.3 XP_016853378.1, XM_016997889.1 |
Genome annotation databases
Ensembli | ENSACAT00000009636; ENSACAP00000009439; ENSACAG00000009646 |
GeneIDi | 100567816 |
KEGGi | acs:100567816 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_003228347.1, XM_003228299.3 XP_016853378.1, XM_016997889.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000009439 |
Genome annotation databases
Ensembli | ENSACAT00000009636; ENSACAP00000009439; ENSACAG00000009646 |
GeneIDi | 100567816 |
KEGGi | acs:100567816 |
Organism-specific databases
CTDi | 54890 |
Phylogenomic databases
eggNOGi | KOG4176, Eukaryota |
GeneTreei | ENSGT00390000009298 |
HOGENOMi | CLU_047472_1_0_1 |
InParanoidi | H9GFF6 |
OMAi | ENYWRRD |
OrthoDBi | 722070at2759 |
TreeFami | TF329212 |
Gene expression databases
Bgeei | ENSACAG00000009646, Expressed in skeletal muscle tissue and 13 other tissues |
Family and domain databases
Gene3Di | 2.60.120.590, 1 hit |
InterProi | View protein in InterPro IPR027450, AlkB-like IPR037151, AlkB-like_sf IPR032860, ALKBH5 |
PANTHERi | PTHR32074, PTHR32074, 2 hits |
Pfami | View protein in Pfam PF13532, 2OG-FeII_Oxy_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | H9GFF6_ANOCA | |
Accessioni | H9GFF6Primary (citable) accession number: H9GFF6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2012 |
Last sequence update: | June 26, 2013 | |
Last modified: | January 19, 2022 | |
This is version 56 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |