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Entry version 50 (07 Apr 2021)
Sequence version 2 (26 Jun 2013)
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Protein
Submitted name:

Uncharacterized protein

Gene

TNS2

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNS2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junctionARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000009385, Expressed in lung and 13 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000009357

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini52 – 224Phosphatase tensin-typeInterPro annotationAdd BLAST173
Domaini229 – 356C2 tensin-typeInterPro annotationAdd BLAST128
Domaini1057 – 1167SH2InterPro annotationAdd BLAST111

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni425 – 483DisorderedSequence analysisAdd BLAST59
Regioni697 – 841DisorderedSequence analysisAdd BLAST145
Regioni878 – 932DisorderedSequence analysisAdd BLAST55
Regioni983 – 1046DisorderedSequence analysisAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi425 – 463PolarSequence analysisAdd BLAST39
Compositional biasi721 – 758PolarSequence analysisAdd BLAST38
Compositional biasi771 – 829PolarSequence analysisAdd BLAST59
Compositional biasi878 – 912PolarSequence analysisAdd BLAST35

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PTEN phosphatase protein family.ARBA annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1930, Eukaryota
KOG2283, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161535

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002189_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H9GFB8

Identification of Orthologs from Complete Genome Data

More...
OMAi
PPLMYGT

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01213, PTB_tensin, 1 hit
cd09927, SH2_Tensin_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit
3.30.505.10, 1 hit
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011993, PH-like_dom_sf
IPR029021, Prot-tyrosine_phosphatase-like
IPR013625, PTB
IPR006020, PTB/PI_dom
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR035012, Tensin-like_SH2
IPR014020, Tensin_C2-dom
IPR029023, Tensin_phosphatase
IPR033929, Tensin_PTB
IPR003595, Tyr_Pase_cat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08416, PTB, 1 hit
PF10409, PTEN_C2, 1 hit
PF00017, SH2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00462, PTB, 1 hit
SM01326, PTEN_C2, 1 hit
SM00404, PTPc_motif, 1 hit
SM00252, SH2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52799, SSF52799, 1 hit
SSF55550, SSF55550, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51182, C2_TENSIN, 1 hit
PS51181, PPASE_TENSIN, 1 hit
PS50001, SH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9GFB8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTIDSSFSL FFPSHIQRRN TAPVRRIEHL GSTKSLNTAK QRNTLPRSFS
60 70 80 90 100
LDHVMERKYD FDLIYITERI ISVFFPPALE EQRYRGNLRE VAQMLKSKHE
110 120 130 140 150
DKYMLLNLSE KRHDIIRLNP KVQDFGWPDL HAPPLDKICS ICKAMETWLT
160 170 180 190 200
SDPQHVVVLH CKGNKGKTGV IVAAYMHYSK ISASADQALS TLTMRKFCED
210 220 230 240 250
KVAASLQPSQ KRYIHYFSGL LSGTIKMNSN TLFLHHVLLP AIPTFEAGGG
260 270 280 290 300
YQPFLKIYQS MQLVYTSGIY SLHGTGGTQK LCITLEPALL LKGDVMVKCY
310 320 330 340 350
HKQLQGNERD VVFRVQFHTC TIHSTQLWFS KDELDEAWRD ERFPFEASVE
360 370 380 390 400
FVFSSSPEKI KGREAYRNNA AVGVDYSISD PIVRWDSYEN FNVHHEDSLE
410 420 430 440 450
ASFWSTFRPI NGGPSGQVCA TVEFSGQSPL PQTEVPSPFL RVNSXSGYSG
460 470 480 490 500
SPHSGSTSPT SPLYPPARKH GYEPPESSDG YILPLATERP RDKLKVLDCS
510 520 530 540 550
SPPIIQSSSF SCASFANFQS SLSLHCSIRK GSKEGAYMHP EKGMENYDSQ
560 570 580 590 600
DGTTWRHRLH RMETTWHNKL SLTRVSWLLP HFPLPQIGET SQFNPESNKV
610 620 630 640 650
ILASSENSVL YPCICPFWKS ARLEVQKPKK YGRLRVDSKY VWLSKCYILL
660 670 680 690 700
LSKYYSHHLL TLVMLAPVDR NCSLTRKIGI KSHVFLSPTL CSTQHYQSAE
710 720 730 740 750
APSSLQQHRQ EGRAPCPDVS RSPMHTSSPV FSNDSPGTHK HSSKTASSPE
760 770 780 790 800
NLHQPSPEEL ATPSWKRGPE KVAPSSSSPT QTVSPMQAFT HLPTLRPQAN
810 820 830 840 850
GTSPPKMGLQ SPQPCSRATC ASSSPHVAPS PTAKHGIFPE GQLHQNGLEI
860 870 880 890 900
TSSCNSALSS ALPAEDHLGH RLSSVVERQA QKSSSGLPCH SQPSPGCRTV
910 920 930 940 950
PSTPSSPQVT AVYNGRPRGE RTEPEMSNFL HCPSRNPSLG PCSVSVQSTS
960 970 980 990 1000
LSYGFADMQG SPTPAFPIAT AYYTGAESSP SIREQLCEPP QPPLPEKHHT
1010 1020 1030 1040 1050
LATRNWERSS PPGRSPGSAH HVTFAPGVPD GSTPGSDPPQ QENQVSVKFV
1060 1070 1080 1090 1100
QDTSKFWYKP HLSRDQAIAL LKNKEPGTFL IRDSNSFQGA YGLALKVATP
1110 1120 1130 1140 1150
PPNSINHSTK VGDPAEQLVR HFLVETGPKG VKIKGCNNEP YFGSLPALVS
1160 1170 1180 1190 1200
QHSITPISLP CRLHIPNKDL VEESPELAVP TNMSTAADLL KQGAACSVLY
1210 1220 1230 1240 1250
LSSVETESLT GPQAVAKATT STLSTTPRPS ASVVHFKVSA QGITLTDNQR
1260 1270 1280 1290 1300
KLFFRRHYPV NTVTFCSTDP QDRRWANPDG TTSKVFGFVA KKQGSPCENV
1310 1320
CHLFAELDPE QPASAIVNFI TKVMLGTHR
Length:1,329
Mass (Da):146,907
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D7169241FA7291E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAWZ02019559 Genomic DNA No translation available.
AAWZ02019560 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000009552; ENSACAP00000009357; ENSACAG00000009385

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02019559 Genomic DNA No translation available.
AAWZ02019560 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000009357

Genome annotation databases

EnsembliENSACAT00000009552; ENSACAP00000009357; ENSACAG00000009385

Phylogenomic databases

eggNOGiKOG1930, Eukaryota
KOG2283, Eukaryota
GeneTreeiENSGT00940000161535
HOGENOMiCLU_002189_1_0_1
InParanoidiH9GFB8
OMAiPPLMYGT

Gene expression databases

BgeeiENSACAG00000009385, Expressed in lung and 13 other tissues

Family and domain databases

CDDicd01213, PTB_tensin, 1 hit
cd09927, SH2_Tensin_like, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR011993, PH-like_dom_sf
IPR029021, Prot-tyrosine_phosphatase-like
IPR013625, PTB
IPR006020, PTB/PI_dom
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR035012, Tensin-like_SH2
IPR014020, Tensin_C2-dom
IPR029023, Tensin_phosphatase
IPR033929, Tensin_PTB
IPR003595, Tyr_Pase_cat
PfamiView protein in Pfam
PF08416, PTB, 1 hit
PF10409, PTEN_C2, 1 hit
PF00017, SH2, 1 hit
SMARTiView protein in SMART
SM00462, PTB, 1 hit
SM01326, PTEN_C2, 1 hit
SM00404, PTPc_motif, 1 hit
SM00252, SH2, 1 hit
SUPFAMiSSF52799, SSF52799, 1 hit
SSF55550, SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS51182, C2_TENSIN, 1 hit
PS51181, PPASE_TENSIN, 1 hit
PS50001, SH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9GFB8_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9GFB8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: June 26, 2013
Last modified: April 7, 2021
This is version 50 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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