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Entry version 35 (12 Aug 2020)
Sequence version 2 (26 Jun 2013)
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Protein

SWIM-type domain-containing protein

Gene

ZSWIM8

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SWIM-type domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZSWIM8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000009522, Expressed in hemipenis and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000009342

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini162 – 198SWIM-typeInterPro annotationAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni587 – 611DisorderedSequence analysisAdd BLAST25
Regioni659 – 714DisorderedSequence analysisAdd BLAST56
Regioni980 – 1015DisorderedSequence analysisAdd BLAST36
Regioni1028 – 1191DisorderedSequence analysisAdd BLAST164
Regioni1586 – 1607DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi662 – 676PolarSequence analysisAdd BLAST15
Compositional biasi696 – 714PolyampholyteSequence analysisAdd BLAST19
Compositional biasi983 – 1015PolarSequence analysisAdd BLAST33
Compositional biasi1028 – 1062PolarSequence analysisAdd BLAST35
Compositional biasi1105 – 1121PolarSequence analysisAdd BLAST17
Compositional biasi1135 – 1163PolarSequence analysisAdd BLAST29

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3615, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156999

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001052_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H9GFB5

TreeFam database of animal gene trees

More...
TreeFami
TF324881

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007527, Znf_SWIM

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50966, ZF_SWIM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9GFB5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELMFAEWED GERFSFEDSD RFEEDSLCSF ISEAESLCQN WRGWRKQSAG
60 70 80 90 100
PNSPTVKMKD GLVIPLVELS AKQVAFHIPF EVVEKVYPPV PEQLQLRIAF
110 120 130 140 150
WSFPENEEDI RLYSCLANGS ADEFQRGEQL FRMRAVKDPL QIGFHLSATV
160 170 180 190 200
VPPQMVPPKG AYNVAVMFDR CRITSCSCTC GAGAKWCAHV VALCLFRIHN
210 220 230 240 250
ASAVCLRAPV SESLSRLQRD QLQKFAQYLI SELPQQILPT AQRLLDELLS
260 270 280 290 300
SQSTAINTVC GAPDPTAGPS ASDQSTWYLD ESTLSDNIKK TLHKFCGPSP
310 320 330 340 350
VVFSDVNSMY LSSTEPPAAA EWACLLRPLR GREPEGIWNL LSIVREMFKR
360 370 380 390 400
RDTNAAPLLE ILTDQCLTYE QITGWWYSVR TSASHSSASG HTGRSNGQSE
410 420 430 440 450
VAAHACASMC DEMVVLWRLA VLDPTISPHR RRDLCTQLRQ WQLKVIDNVK
460 470 480 490 500
RGQHKKSLEK LFYGFKPAVE ACYFNWEEAY PIPGITYSSA DKKNSFCWVK
510 520 530 540 550
AIQQRNCRPQ CSELCDAGRS HGTDAAGMCV QLGERSRLAS QEPAVRPKEL
560 570 580 590 600
IGKRKIVSEG PQRVLRRLSA EGDKATYKTA VNKGKLPVGK NLASKHSGKR
610 620 630 640 650
RMSSEDSSLE PDLAELTLDD SSLALGAEAS NTFSFPDSPL NRSYRDTYED
660 670 680 690 700
DGGVYFSEAA EPTLRSSPST KKNPKDSVGE VCSGDDDVPC PDESTGGEVT
710 720 730 740 750
KEEDEKAEGG TEEEQDMFAG IKPLEQENRM EILFACAEAL YAHGYSNEAC
760 770 780 790 800
CLTVELAKDL LANPPDLKVE QPQTKGKKNK VSTTKQTLMA TNTLSKAAFL
810 820 830 840 850
LTVLSERQEY HNLAFQIGMF ALELQRPPAS TKALEVKLAY QESEIVALLK
860 870 880 890 900
KIPLGSNEMN TIRGRAEELR EGTLCDYRPV LPLMLASFIF DVLCTPVVSP
910 920 930 940 950
TGSRPPSRNW NNEMPGDEEL GFEAAVAALG MKTTVSEAEH PLLCEGTRRE
960 970 980 990 1000
KGDLALALMI TYKDDQSKLK KILDKLLDRE SQTHKPQTIS SFYSSSKPTV
1010 1020 1030 1040 1050
PSQKSPSKHA TQSAAPIQHL PGASVTQQTG VPATVQSNPS EPFLEKSTQE
1060 1070 1080 1090 1100
NPQRSLCEPS VESSILKQEG KVPSRLALGN RGGYNGRCWG SPVRQKKKHT
1110 1120 1130 1140 1150
GMASIDSSAP ETTSDSSPTL SRRPLRGGWA ATSWGRGQDS DSISSSSSDS
1160 1170 1180 1190 1200
LGSSSSSGSR RASGGARAKT VEVGRYKGRR PESHAPHVPN QPSEAAAHFY
1210 1220 1230 1240 1250
FELAKTVLIK AGGNSSTSIF THPSSSGGHQ GPHRNLHLCA FEIGLYALGL
1260 1270 1280 1290 1300
HNFVSPNWLS RTYSSHVSWI TGQAMEIGSA ALNILVECWD GHLTPPEVAS
1310 1320 1330 1340 1350
LADRASRARD SNMVRAAAEL ALSCLPHAHA LNPNEIQRAL VQCKEQDNLM
1360 1370 1380 1390 1400
MEKACLAVEE AAKGGGVYPE VLFEVAHQWY WLYEQTVGGT LAQREGATGC
1410 1420 1430 1440 1450
SASGARASCE AVRGLADTRV TSEPTTVTVA AAVTAAATVV PVISVGSTIY
1460 1470 1480 1490 1500
QQHTMAGPAM AHAHTQGLHP YTTLQTHIPC NPQYIGHPMQ HMPRPAVFPV
1510 1520 1530 1540 1550
PGTAYPQGVH PAFIGAQYPY SVTSPSLAAT AVSFPGVPVP SMTQIAVHPY
1560 1570 1580 1590 1600
HAETGLSLSS NVAIGSVHAG STFPAIQGTT LTSLSSQPSS LVTGGFPSED
1610 1620 1630 1640 1650
EQHSQPVSPQ GLHYLHSAYR VGMLALEMLG RRAHNDHPNN FSRSPPYTED
1660 1670 1680 1690 1700
VKWLLGLAAK LGVNYVHQFC VGAAKGVLSP FVLQEIIMES LQRLNPAHVH
1710 1720 1730 1740 1750
NHLRTPAFHQ LVQRCQQAYI QYIHHRLIHL TPADYDDFVN AIRSARSAFC
1760 1770 1780
LTPMGMMQFN DILQNLKRSK QTKDLWQRVS LEMTTFSP
Length:1,788
Mass (Da):195,728
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i54FE36EDFB795430
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAWZ02010489 Genomic DNA No translation available.
AAWZ02010490 Genomic DNA No translation available.
AAWZ02010491 Genomic DNA No translation available.
AAWZ02010492 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000009537; ENSACAP00000009342; ENSACAG00000009522

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02010489 Genomic DNA No translation available.
AAWZ02010490 Genomic DNA No translation available.
AAWZ02010491 Genomic DNA No translation available.
AAWZ02010492 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000009342

Genome annotation databases

EnsembliENSACAT00000009537; ENSACAP00000009342; ENSACAG00000009522

Phylogenomic databases

eggNOGiKOG3615, Eukaryota
GeneTreeiENSGT00940000156999
HOGENOMiCLU_001052_0_0_1
InParanoidiH9GFB5
TreeFamiTF324881

Gene expression databases

BgeeiENSACAG00000009522, Expressed in hemipenis and 14 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR007527, Znf_SWIM
PROSITEiView protein in PROSITE
PS50966, ZF_SWIM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9GFB5_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9GFB5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: June 26, 2013
Last modified: August 12, 2020
This is version 35 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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