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UniProtKB - H9GFB5 (H9GFB5_ANOCA)

Entry version 35 (12 Aug 2020)
Sequence version 2 (26 Jun 2013)
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Protein

SWIM-type domain-containing protein

Gene

ZSWIM8

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • regulation of axon guidance Source: GO_Central
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SWIM-type domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZSWIM8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSACAG00000009522, Expressed in hemipenis and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		28377.ENSACAP00000009342

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini162 – 198SWIM-typeInterPro annotationAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni587 – 611DisorderedSequence analysisAdd BLAST25
Regioni659 – 714DisorderedSequence analysisAdd BLAST56
Regioni980 – 1015DisorderedSequence analysisAdd BLAST36
Regioni1028 – 1191DisorderedSequence analysisAdd BLAST164
Regioni1586 – 1607DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi662 – 676PolarSequence analysisAdd BLAST15
Compositional biasi696 – 714PolyampholyteSequence analysisAdd BLAST19
Compositional biasi983 – 1015PolarSequence analysisAdd BLAST33
Compositional biasi1028 – 1062PolarSequence analysisAdd BLAST35
Compositional biasi1105 – 1121PolarSequence analysisAdd BLAST17
Compositional biasi1135 – 1163PolarSequence analysisAdd BLAST29

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3615, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156999

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001052_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		H9GFB5

TreeFam database of animal gene trees

More...TreeFami		TF324881

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007527, Znf_SWIM

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50966, ZF_SWIM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H9GFB5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELMFAEWED GERFSFEDSD RFEEDSLCSF ISEAESLCQN WRGWRKQSAG 
        60         70         80         90        100
PNSPTVKMKD GLVIPLVELS AKQVAFHIPF EVVEKVYPPV PEQLQLRIAF 
       110        120        130        140        150
WSFPENEEDI RLYSCLANGS ADEFQRGEQL FRMRAVKDPL QIGFHLSATV 
       160        170        180        190        200
VPPQMVPPKG AYNVAVMFDR CRITSCSCTC GAGAKWCAHV VALCLFRIHN 
       210        220        230        240        250
ASAVCLRAPV SESLSRLQRD QLQKFAQYLI SELPQQILPT AQRLLDELLS 
       260        270        280        290        300
SQSTAINTVC GAPDPTAGPS ASDQSTWYLD ESTLSDNIKK TLHKFCGPSP 
       310        320        330        340        350
VVFSDVNSMY LSSTEPPAAA EWACLLRPLR GREPEGIWNL LSIVREMFKR 
       360        370        380        390        400
RDTNAAPLLE ILTDQCLTYE QITGWWYSVR TSASHSSASG HTGRSNGQSE 
       410        420        430        440        450
VAAHACASMC DEMVVLWRLA VLDPTISPHR RRDLCTQLRQ WQLKVIDNVK 
       460        470        480        490        500
RGQHKKSLEK LFYGFKPAVE ACYFNWEEAY PIPGITYSSA DKKNSFCWVK 
       510        520        530        540        550
AIQQRNCRPQ CSELCDAGRS HGTDAAGMCV QLGERSRLAS QEPAVRPKEL 
       560        570        580        590        600
IGKRKIVSEG PQRVLRRLSA EGDKATYKTA VNKGKLPVGK NLASKHSGKR 
       610        620        630        640        650
RMSSEDSSLE PDLAELTLDD SSLALGAEAS NTFSFPDSPL NRSYRDTYED 
       660        670        680        690        700
DGGVYFSEAA EPTLRSSPST KKNPKDSVGE VCSGDDDVPC PDESTGGEVT 
       710        720        730        740        750
KEEDEKAEGG TEEEQDMFAG IKPLEQENRM EILFACAEAL YAHGYSNEAC 
       760        770        780        790        800
CLTVELAKDL LANPPDLKVE QPQTKGKKNK VSTTKQTLMA TNTLSKAAFL 
       810        820        830        840        850
LTVLSERQEY HNLAFQIGMF ALELQRPPAS TKALEVKLAY QESEIVALLK 
       860        870        880        890        900
KIPLGSNEMN TIRGRAEELR EGTLCDYRPV LPLMLASFIF DVLCTPVVSP 
       910        920        930        940        950
TGSRPPSRNW NNEMPGDEEL GFEAAVAALG MKTTVSEAEH PLLCEGTRRE 
       960        970        980        990       1000
KGDLALALMI TYKDDQSKLK KILDKLLDRE SQTHKPQTIS SFYSSSKPTV 
      1010       1020       1030       1040       1050
PSQKSPSKHA TQSAAPIQHL PGASVTQQTG VPATVQSNPS EPFLEKSTQE 
      1060       1070       1080       1090       1100
NPQRSLCEPS VESSILKQEG KVPSRLALGN RGGYNGRCWG SPVRQKKKHT 
      1110       1120       1130       1140       1150
GMASIDSSAP ETTSDSSPTL SRRPLRGGWA ATSWGRGQDS DSISSSSSDS 
      1160       1170       1180       1190       1200
LGSSSSSGSR RASGGARAKT VEVGRYKGRR PESHAPHVPN QPSEAAAHFY 
      1210       1220       1230       1240       1250
FELAKTVLIK AGGNSSTSIF THPSSSGGHQ GPHRNLHLCA FEIGLYALGL 
      1260       1270       1280       1290       1300
HNFVSPNWLS RTYSSHVSWI TGQAMEIGSA ALNILVECWD GHLTPPEVAS 
      1310       1320       1330       1340       1350
LADRASRARD SNMVRAAAEL ALSCLPHAHA LNPNEIQRAL VQCKEQDNLM 
      1360       1370       1380       1390       1400
MEKACLAVEE AAKGGGVYPE VLFEVAHQWY WLYEQTVGGT LAQREGATGC 
      1410       1420       1430       1440       1450
SASGARASCE AVRGLADTRV TSEPTTVTVA AAVTAAATVV PVISVGSTIY 
      1460       1470       1480       1490       1500
QQHTMAGPAM AHAHTQGLHP YTTLQTHIPC NPQYIGHPMQ HMPRPAVFPV 
      1510       1520       1530       1540       1550
PGTAYPQGVH PAFIGAQYPY SVTSPSLAAT AVSFPGVPVP SMTQIAVHPY 
      1560       1570       1580       1590       1600
HAETGLSLSS NVAIGSVHAG STFPAIQGTT LTSLSSQPSS LVTGGFPSED 
      1610       1620       1630       1640       1650
EQHSQPVSPQ GLHYLHSAYR VGMLALEMLG RRAHNDHPNN FSRSPPYTED 
      1660       1670       1680       1690       1700
VKWLLGLAAK LGVNYVHQFC VGAAKGVLSP FVLQEIIMES LQRLNPAHVH 
      1710       1720       1730       1740       1750
NHLRTPAFHQ LVQRCQQAYI QYIHHRLIHL TPADYDDFVN AIRSARSAFC 
      1760       1770       1780 
LTPMGMMQFN DILQNLKRSK QTKDLWQRVS LEMTTFSP
Length:1,788
Mass (Da):195,728
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i54FE36EDFB795430
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AAWZ02010489 Genomic DNA No translation available.
AAWZ02010490 Genomic DNA No translation available.
AAWZ02010491 Genomic DNA No translation available.
AAWZ02010492 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSACAT00000009537; ENSACAP00000009342; ENSACAG00000009522

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAWZ02010489 Genomic DNA No translation available.
AAWZ02010490 Genomic DNA No translation available.
AAWZ02010491 Genomic DNA No translation available.
AAWZ02010492 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000009342

Genome annotation databases

EnsembliENSACAT00000009537; ENSACAP00000009342; ENSACAG00000009522

Phylogenomic databases

eggNOGiKOG3615, Eukaryota
GeneTreeiENSGT00940000156999
HOGENOMiCLU_001052_0_0_1
InParanoidiH9GFB5
TreeFamiTF324881

Gene expression databases

BgeeiENSACAG00000009522, Expressed in hemipenis and 14 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR007527, Znf_SWIM
PROSITEiView protein in PROSITE
PS50966, ZF_SWIM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH9GFB5_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H9GFB5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: June 26, 2013
Last modified: August 12, 2020
This is version 35 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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